The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8298 |
Resumo: | Review |
| id |
RCAP_384828aae361c4f9dac3faa888d6e7cb |
|---|---|
| oai_identifier_str |
oai:repositorio.insa.pt:10400.18/8298 |
| network_acronym_str |
RCAP |
| network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository_id_str |
7160 |
| spelling |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive ReviewPolycyclic Aromatic HydrocarbonsPAHsEnvironmental GenotoxicityHuman BiomonitoringOccupational ExposureExposure BiomarkerEffect BiomarkerGenotoxicidade AmbientalEuropeReviewThis article belongs to the Special Issue Biomonitoring of Human Exposure: From Individual to Group Exposure AssessmentPolycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers’ health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008–2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.This project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU.MDPIRepositório Científico do Instituto Nacional de SaúdeLouro, HenriquetaGomes, Bruno CostaSaber, Anne ThoustrupIamiceli, Anna LauraGöen, ThomasJones, KateKatsonouri, AndromachiNeophytou, Christiana M.Vogel, UllaVentura, CéliaOberemm, AxelDuca, Radu CorneliuFernandez, Mariana F.Olea, NicolasSantonen, TiinaViegas, SusanaSilva, Maria João2022-11-02T14:43:36Z2022-08-172022-08-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8298engToxics. 2022 Aug 17;10(8):480. doi: 10.3390/toxics100804802305-630410.3390/toxics10080480info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:30Zoai:repositorio.insa.pt:10400.18/8298Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:58.787083Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| title |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| spellingShingle |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review Louro, Henriqueta Polycyclic Aromatic Hydrocarbons PAHs Environmental Genotoxicity Human Biomonitoring Occupational Exposure Exposure Biomarker Effect Biomarker Genotoxicidade Ambiental Europe |
| title_short |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| title_full |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| title_fullStr |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| title_full_unstemmed |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| title_sort |
The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review |
| author |
Louro, Henriqueta |
| author_facet |
Louro, Henriqueta Gomes, Bruno Costa Saber, Anne Thoustrup Iamiceli, Anna Laura Göen, Thomas Jones, Kate Katsonouri, Andromachi Neophytou, Christiana M. Vogel, Ulla Ventura, Célia Oberemm, Axel Duca, Radu Corneliu Fernandez, Mariana F. Olea, Nicolas Santonen, Tiina Viegas, Susana Silva, Maria João |
| author_role |
author |
| author2 |
Gomes, Bruno Costa Saber, Anne Thoustrup Iamiceli, Anna Laura Göen, Thomas Jones, Kate Katsonouri, Andromachi Neophytou, Christiana M. Vogel, Ulla Ventura, Célia Oberemm, Axel Duca, Radu Corneliu Fernandez, Mariana F. Olea, Nicolas Santonen, Tiina Viegas, Susana Silva, Maria João |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Louro, Henriqueta Gomes, Bruno Costa Saber, Anne Thoustrup Iamiceli, Anna Laura Göen, Thomas Jones, Kate Katsonouri, Andromachi Neophytou, Christiana M. Vogel, Ulla Ventura, Célia Oberemm, Axel Duca, Radu Corneliu Fernandez, Mariana F. Olea, Nicolas Santonen, Tiina Viegas, Susana Silva, Maria João |
| dc.subject.por.fl_str_mv |
Polycyclic Aromatic Hydrocarbons PAHs Environmental Genotoxicity Human Biomonitoring Occupational Exposure Exposure Biomarker Effect Biomarker Genotoxicidade Ambiental Europe |
| topic |
Polycyclic Aromatic Hydrocarbons PAHs Environmental Genotoxicity Human Biomonitoring Occupational Exposure Exposure Biomarker Effect Biomarker Genotoxicidade Ambiental Europe |
| description |
Review |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-02T14:43:36Z 2022-08-17 2022-08-17T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8298 |
| url |
http://hdl.handle.net/10400.18/8298 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Toxics. 2022 Aug 17;10(8):480. doi: 10.3390/toxics10080480 2305-6304 10.3390/toxics10080480 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
| instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
| institution |
RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| repository.mail.fl_str_mv |
|
| _version_ |
1799132175840313344 |