Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample

Detalhes bibliográficos
Autor(a) principal: Duarte, Nuno
Data de Publicação: 2023
Outros Autores: Amaral, Sarah, Abrantes, Marta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.25753/BirthGrowthMJ.v32.i3.29052
Resumo: Background: The adolescent population is at high risk for depressive disorders, and suicide is a leading cause of death in this age group worldwide. Selective serotonin reuptake inhibitors (SSRIs) remain the only approved pharmacological approach, despite concerns about suicidality. Objectives: This study aimed to understand the relationship between antidepressant use and suicidality in an adolescent population from an Adolescent Psychiatric unit in Lisbon, Portugal. Methods: A total of 296 medical reports of adolescent patients with depressive symptoms in psychiatric follow-up at the considered unit were reviewed. Two demographically and clinically similar samples were obtained, one exposed to SSRI treatment and one control group. Results: A risk of suicide attempt of 0.006 was found in the group exposed to SSRIs versus 0.025 in the control group, corresponding to a relative risk of suicidality of 0.248. This difference did not reach statistical significance, despite a Bayes factor of 4.57 and a Pearson’s r of -0.078. Conclusions: The study results suggest that SSRIs do not increase the risk of suicide attempt in adolescents with depressive symptoms.
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spelling Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sampleInibidores seletivos de recaptação da serotonina e risco de suicídio numa amostra portuguesa de adolescentesOriginal ArticlesBackground: The adolescent population is at high risk for depressive disorders, and suicide is a leading cause of death in this age group worldwide. Selective serotonin reuptake inhibitors (SSRIs) remain the only approved pharmacological approach, despite concerns about suicidality. Objectives: This study aimed to understand the relationship between antidepressant use and suicidality in an adolescent population from an Adolescent Psychiatric unit in Lisbon, Portugal. Methods: A total of 296 medical reports of adolescent patients with depressive symptoms in psychiatric follow-up at the considered unit were reviewed. Two demographically and clinically similar samples were obtained, one exposed to SSRI treatment and one control group. Results: A risk of suicide attempt of 0.006 was found in the group exposed to SSRIs versus 0.025 in the control group, corresponding to a relative risk of suicidality of 0.248. This difference did not reach statistical significance, despite a Bayes factor of 4.57 and a Pearson’s r of -0.078. Conclusions: The study results suggest that SSRIs do not increase the risk of suicide attempt in adolescents with depressive symptoms.Introdução: A adolescência está associada a um risco elevado de perturbações depressivas, sendo o suicídio uma das principais causas de morte nesta faixa etária globalmente. Os inibidores seletivos de recaptação da serotonina (SSRIs) são a única terapêutica farmacológica aprovada internacionalmente neste contexto, apesar das preocupações com o risco de suicídio. Objetivos: Este estudo procurou identificar a relação entre o uso de antidepressivos e o risco de suicídio numa amostra de adolescentes com sintomas depressivos seguidos numa Unidade de Psiquiatria da Adolescência em Lisboa, Portugal. Métodos: Foram analisados os processos clínicos de 296 doentes com sintomatologia depressiva em seguimento na consulta de Psiquiatria da Adolescência. Foram obtidas duas amostras demográfica e clinicamente semelhantes, uma exposta a tratamento com SSRIs e outra sem exposição aos fármacos (grupo controlo). Resultados: Os resultados revelaram um risco de suicídio de 0.006 no grupo exposto aos psicofármacos e 0.025 no grupo controlo, correspondente a um risco relativo de suicídio de 0.248. Esta diferença não foi estatisticamente significativa, apesar do fator de Bayes de 4.57 e do r de Pearson de -0.078. Conclusões: Os resultados sugerem que os SSRIs não aumentam o risco de tentativa de suicídio entre adolescentes com sintomas depressivos.Centro Hospitalar Universitário de Santo António2023-11-16info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.25753/BirthGrowthMJ.v32.i3.29052eng2183-9417Duarte, NunoAmaral, SarahAbrantes, Martainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-16T17:28:54Zoai:ojs.revistas.rcaap.pt:article/29052Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:53:52.125378Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
Inibidores seletivos de recaptação da serotonina e risco de suicídio numa amostra portuguesa de adolescentes
title Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
spellingShingle Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
Duarte, Nuno
Original Articles
title_short Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
title_full Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
title_fullStr Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
title_full_unstemmed Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
title_sort Serotonin selective reuptake inhibitors and suicide risk in a Portuguese adolescent sample
author Duarte, Nuno
author_facet Duarte, Nuno
Amaral, Sarah
Abrantes, Marta
author_role author
author2 Amaral, Sarah
Abrantes, Marta
author2_role author
author
dc.contributor.author.fl_str_mv Duarte, Nuno
Amaral, Sarah
Abrantes, Marta
dc.subject.por.fl_str_mv Original Articles
topic Original Articles
description Background: The adolescent population is at high risk for depressive disorders, and suicide is a leading cause of death in this age group worldwide. Selective serotonin reuptake inhibitors (SSRIs) remain the only approved pharmacological approach, despite concerns about suicidality. Objectives: This study aimed to understand the relationship between antidepressant use and suicidality in an adolescent population from an Adolescent Psychiatric unit in Lisbon, Portugal. Methods: A total of 296 medical reports of adolescent patients with depressive symptoms in psychiatric follow-up at the considered unit were reviewed. Two demographically and clinically similar samples were obtained, one exposed to SSRI treatment and one control group. Results: A risk of suicide attempt of 0.006 was found in the group exposed to SSRIs versus 0.025 in the control group, corresponding to a relative risk of suicidality of 0.248. This difference did not reach statistical significance, despite a Bayes factor of 4.57 and a Pearson’s r of -0.078. Conclusions: The study results suggest that SSRIs do not increase the risk of suicide attempt in adolescents with depressive symptoms.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-16
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.25753/BirthGrowthMJ.v32.i3.29052
url https://doi.org/10.25753/BirthGrowthMJ.v32.i3.29052
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2183-9417
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Centro Hospitalar Universitário de Santo António
publisher.none.fl_str_mv Centro Hospitalar Universitário de Santo António
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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