Systemic Lupus Erythematosus and Pregnancy

Detalhes bibliográficos
Autor(a) principal: Diniz-da-Costa, Teresa
Data de Publicação: 2013
Outros Autores: Centeno, Mónica, Pinto, Luísa, Marques, Aurora, Mendes-Graça, Luís
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1364
Resumo: Systemic lupus erythematosus is a chronic inflammatory disease, resulting from an auto-immune dysfunction. The etiology of this diseaseis unknown. It frequently occurs in women of childbearing age. Pregnancy in patients with systemic lupus erythematosus may beassociated with several complications (maternal, obstetrical and fetal). The prognosis for both mother and child is better when systemiclupus erythematosus has been quiescent for at least six months before pregnancy. Thus, preconceptional assessment and managementis crucial for helping women to achieve a period of disease remission before pregnancy as well as for allowing an adjustment oftherapy. Maternal health and fetal development should be closely monitored during pregnancy. These patients should be surveilled by amultidisciplinary team (obstetrician, rheumatologist or internist, nephrologist if necessary and a pediatrician), in a tertiary care hospital.Antiphospholipid syndrome, positivity for anti-SSA/Ro or anti-SSB/LA antibodies, hypertension or renal involvement are associatedwith an increase of adverse pregnancy outcomes. In this article the authors review the main aspects of Systemic lupus erythematosus(SLE) and pregnancy.
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spelling Systemic Lupus Erythematosus and PregnancyLupus Eritematoso Sistémico e GravidezSystemic lupus erythematosus is a chronic inflammatory disease, resulting from an auto-immune dysfunction. The etiology of this diseaseis unknown. It frequently occurs in women of childbearing age. Pregnancy in patients with systemic lupus erythematosus may beassociated with several complications (maternal, obstetrical and fetal). The prognosis for both mother and child is better when systemiclupus erythematosus has been quiescent for at least six months before pregnancy. Thus, preconceptional assessment and managementis crucial for helping women to achieve a period of disease remission before pregnancy as well as for allowing an adjustment oftherapy. Maternal health and fetal development should be closely monitored during pregnancy. These patients should be surveilled by amultidisciplinary team (obstetrician, rheumatologist or internist, nephrologist if necessary and a pediatrician), in a tertiary care hospital.Antiphospholipid syndrome, positivity for anti-SSA/Ro or anti-SSB/LA antibodies, hypertension or renal involvement are associatedwith an increase of adverse pregnancy outcomes. In this article the authors review the main aspects of Systemic lupus erythematosus(SLE) and pregnancy.O Lupus eritematoso sistémico é uma doença inflamatória crónica que resulta de uma desregulação do sistema imunitário. A suaetiologia é desconhecida. O Lupus eritematoso sistémico ocorre frequentemente em mulheres em idade reprodutiva e a sua associaçãocom a gravidez pode colocar problemas maternos (relacionados com a doença de base), obstétricos e fetais. O prognóstico, quermaterno quer fetal, é melhor quando a doença se encontra em remissão ou quiescente, pelo menos nos seis meses anteriores à concepção.Desta forma, o aconselhamento pré-concepcional é fundamental, uma vez que permite não só programar a gravidez para queesta ocorra com a doença em remissão, como também optimizar a terapêutica instituída. Comparativamente a uma gestação de baixorisco, a gravidez numa doente afectada com Lupus eritematoso sistémico obriga a uma maior vigilância obstétrica e do bem-estar fetal.Esta vigilância deve ser efectuada por uma equipa multidisciplinar que englobe obstetra, reumatologista ou internista, nefrologista(se necessário) e pediatra, num hospital de cuidados terciários. Algumas situações clínicas merecem particular atenção, uma vez quecondicionam um maior risco de desfechos adversos durante a gravidez. São exemplos, o síndrome de anticorpos anti-fosfolipídicos, apresença de anticorpos anti-SSA/Ro ou anti-SSB/La, a existência de hipertensão arterial ou de envolvimento renal. Neste artigo é feitauma revisão geral sobre Lupus eritematoso sistémico (LES) e gravidez.Ordem dos Médicos2013-01-28info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/x-pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1364oai:ojs.www.actamedicaportuguesa.com:article/1364Acta Médica Portuguesa; Vol. 25 No. 6 (2012): November-December; 448-453Acta Médica Portuguesa; Vol. 25 N.º 6 (2012): Novembro-Dezembro; 448-4531646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1364https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1364/956Diniz-da-Costa, TeresaCenteno, MónicaPinto, LuísaMarques, AuroraMendes-Graça, Luísinfo:eu-repo/semantics/openAccess2022-12-20T10:57:47Zoai:ojs.www.actamedicaportuguesa.com:article/1364Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:17:05.593968Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Systemic Lupus Erythematosus and Pregnancy
Lupus Eritematoso Sistémico e Gravidez
title Systemic Lupus Erythematosus and Pregnancy
spellingShingle Systemic Lupus Erythematosus and Pregnancy
Diniz-da-Costa, Teresa
title_short Systemic Lupus Erythematosus and Pregnancy
title_full Systemic Lupus Erythematosus and Pregnancy
title_fullStr Systemic Lupus Erythematosus and Pregnancy
title_full_unstemmed Systemic Lupus Erythematosus and Pregnancy
title_sort Systemic Lupus Erythematosus and Pregnancy
author Diniz-da-Costa, Teresa
author_facet Diniz-da-Costa, Teresa
Centeno, Mónica
Pinto, Luísa
Marques, Aurora
Mendes-Graça, Luís
author_role author
author2 Centeno, Mónica
Pinto, Luísa
Marques, Aurora
Mendes-Graça, Luís
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Diniz-da-Costa, Teresa
Centeno, Mónica
Pinto, Luísa
Marques, Aurora
Mendes-Graça, Luís
description Systemic lupus erythematosus is a chronic inflammatory disease, resulting from an auto-immune dysfunction. The etiology of this diseaseis unknown. It frequently occurs in women of childbearing age. Pregnancy in patients with systemic lupus erythematosus may beassociated with several complications (maternal, obstetrical and fetal). The prognosis for both mother and child is better when systemiclupus erythematosus has been quiescent for at least six months before pregnancy. Thus, preconceptional assessment and managementis crucial for helping women to achieve a period of disease remission before pregnancy as well as for allowing an adjustment oftherapy. Maternal health and fetal development should be closely monitored during pregnancy. These patients should be surveilled by amultidisciplinary team (obstetrician, rheumatologist or internist, nephrologist if necessary and a pediatrician), in a tertiary care hospital.Antiphospholipid syndrome, positivity for anti-SSA/Ro or anti-SSB/LA antibodies, hypertension or renal involvement are associatedwith an increase of adverse pregnancy outcomes. In this article the authors review the main aspects of Systemic lupus erythematosus(SLE) and pregnancy.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-28
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https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/1364/956
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dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 25 No. 6 (2012): November-December; 448-453
Acta Médica Portuguesa; Vol. 25 N.º 6 (2012): Novembro-Dezembro; 448-453
1646-0758
0870-399X
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