Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion

Detalhes bibliográficos
Autor(a) principal: Del Campo, Ruben
Data de Publicação: 2017
Outros Autores: Savoini, Begona, Jordao, Luisa, Munoz, A, Monge, M A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/4908
Resumo: In this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time.
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spelling Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusionMg-HAP CompositesCytocompatibilityBiofilmsIn this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time.S2013/MIT-2862-MULTIMAT-CHALLENGE ProgramElsevierRepositório Científico do Instituto Nacional de SaúdeDel Campo, RubenSavoini, BegonaJordao, LuisaMunoz, AMonge, M A2019-09-01T00:30:13Z2017-09-012017-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4908engMater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:667-673. doi: 10.1016/j.msec.2017.04.143. Epub 2017 Apr 23.0928-4931http://dx.doi.org/10.1016/j.msec.2017.04.143info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:28Zoai:repositorio.insa.pt:10400.18/4908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:28.599843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
title Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
spellingShingle Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
Del Campo, Ruben
Mg-HAP Composites
Cytocompatibility
Biofilms
title_short Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
title_full Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
title_fullStr Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
title_full_unstemmed Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
title_sort Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
author Del Campo, Ruben
author_facet Del Campo, Ruben
Savoini, Begona
Jordao, Luisa
Munoz, A
Monge, M A
author_role author
author2 Savoini, Begona
Jordao, Luisa
Munoz, A
Monge, M A
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Del Campo, Ruben
Savoini, Begona
Jordao, Luisa
Munoz, A
Monge, M A
dc.subject.por.fl_str_mv Mg-HAP Composites
Cytocompatibility
Biofilms
topic Mg-HAP Composites
Cytocompatibility
Biofilms
description In this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
2017-09-01T00:00:00Z
2019-09-01T00:30:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/4908
url http://hdl.handle.net/10400.18/4908
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:667-673. doi: 10.1016/j.msec.2017.04.143. Epub 2017 Apr 23.
0928-4931
http://dx.doi.org/10.1016/j.msec.2017.04.143
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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