Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/4908 |
Resumo: | In this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time. |
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Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusionMg-HAP CompositesCytocompatibilityBiofilmsIn this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time.S2013/MIT-2862-MULTIMAT-CHALLENGE ProgramElsevierRepositório Científico do Instituto Nacional de SaúdeDel Campo, RubenSavoini, BegonaJordao, LuisaMunoz, AMonge, M A2019-09-01T00:30:13Z2017-09-012017-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/4908engMater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:667-673. doi: 10.1016/j.msec.2017.04.143. Epub 2017 Apr 23.0928-4931http://dx.doi.org/10.1016/j.msec.2017.04.143info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:28Zoai:repositorio.insa.pt:10400.18/4908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:39:28.599843Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
title |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
spellingShingle |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion Del Campo, Ruben Mg-HAP Composites Cytocompatibility Biofilms |
title_short |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
title_full |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
title_fullStr |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
title_full_unstemmed |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
title_sort |
Cytocompatibility, biofilm assembly and corrosion behavior of Mg-HAP composites processed by extrusion |
author |
Del Campo, Ruben |
author_facet |
Del Campo, Ruben Savoini, Begona Jordao, Luisa Munoz, A Monge, M A |
author_role |
author |
author2 |
Savoini, Begona Jordao, Luisa Munoz, A Monge, M A |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Del Campo, Ruben Savoini, Begona Jordao, Luisa Munoz, A Monge, M A |
dc.subject.por.fl_str_mv |
Mg-HAP Composites Cytocompatibility Biofilms |
topic |
Mg-HAP Composites Cytocompatibility Biofilms |
description |
In this work the cytocompatibility of pure magnesiumandMg-xHAP composites (x=5, 10 and 15wt%) fabricated by powder metallurgy routes has been investigated. The materials were produced from raw HAP powders with particle mean sizes of 6 μm (S-xHAP) or 25 μm (L-xHAP). The biocompatibility study has been performed forMC3T3 cells (osteoblasts/osteoclasts) and L929 fibroblasts. The results indicate that S-Mg (pure magnesium), S-10HAP and L-10HAP composites are the materials with the best biocompatibility. The ability of S. aureus bacteria to assemble biofilms was also evaluated. Biofilm formation assays showed that these materials are not particular prone to colonization and biofilm assembly is strain dependent. The corrosion resistance of S-Mg, S-10HAP and L-10HAP materials immersed in the media used for the cells culture has also been analyzed. Different trends in the corrosion resistance have been found: S-Mg and S-10HAP showa very high resistance to corrosionwhereas the corrosion of L-10HAP steadily increases with time. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-01 2017-09-01T00:00:00Z 2019-09-01T00:30:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/4908 |
url |
http://hdl.handle.net/10400.18/4908 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:667-673. doi: 10.1016/j.msec.2017.04.143. Epub 2017 Apr 23. 0928-4931 http://dx.doi.org/10.1016/j.msec.2017.04.143 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132134390104064 |