A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation

Detalhes bibliográficos
Autor(a) principal: Pais-Vieira, Miguel
Data de Publicação: 2016
Outros Autores: Yadav, Amol P., Moreira, Derek, Guggenmos, David, Santos, Amílcar, Lebedev, Mikhail, Nicolelis, Miguel A. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/45294
Resumo: Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.
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spelling A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulationCiências Médicas::Ciências da SaúdeCiências Médicas::Medicina BásicaScience & TechnologyAlthough electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.We are grateful for the assistance from Jim Meloy for the design and production of the multielectrode arrays as well as setup development and maintenance, Laura Oliveira, Terry Jones, and Susan Halkiotis for administrative assistance and preparation of the manuscript. This work was funded by a grant from The Hartwell Foundation.info:eu-repo/semantics/publishedVersionNature Publishing GroupUniversidade do MinhoPais-Vieira, MiguelYadav, Amol P.Moreira, DerekGuggenmos, DavidSantos, AmílcarLebedev, MikhailNicolelis, Miguel A. L.2016-092016-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/45294engPais-Vieira, M., Yadav, A. P., Moreira, D., Guggenmos, D., Santos, A., Lebedev, M., & Nicolelis, M. A. L. (2016). A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific Reports, 6. doi: 10.1038/srep328142045-232210.1038/srep3281427605389http://www.nature.com/articles/srep32814info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:49Zoai:repositorium.sdum.uminho.pt:1822/45294Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:59.209908Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
title A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
spellingShingle A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
Pais-Vieira, Miguel
Ciências Médicas::Ciências da Saúde
Ciências Médicas::Medicina Básica
Science & Technology
title_short A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
title_full A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
title_fullStr A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
title_full_unstemmed A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
title_sort A closed loop brain-machine interface for epilepsy control using dorsal column electrical stimulation
author Pais-Vieira, Miguel
author_facet Pais-Vieira, Miguel
Yadav, Amol P.
Moreira, Derek
Guggenmos, David
Santos, Amílcar
Lebedev, Mikhail
Nicolelis, Miguel A. L.
author_role author
author2 Yadav, Amol P.
Moreira, Derek
Guggenmos, David
Santos, Amílcar
Lebedev, Mikhail
Nicolelis, Miguel A. L.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pais-Vieira, Miguel
Yadav, Amol P.
Moreira, Derek
Guggenmos, David
Santos, Amílcar
Lebedev, Mikhail
Nicolelis, Miguel A. L.
dc.subject.por.fl_str_mv Ciências Médicas::Ciências da Saúde
Ciências Médicas::Medicina Básica
Science & Technology
topic Ciências Médicas::Ciências da Saúde
Ciências Médicas::Medicina Básica
Science & Technology
description Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.
publishDate 2016
dc.date.none.fl_str_mv 2016-09
2016-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/45294
url http://hdl.handle.net/1822/45294
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pais-Vieira, M., Yadav, A. P., Moreira, D., Guggenmos, D., Santos, A., Lebedev, M., & Nicolelis, M. A. L. (2016). A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation. Scientific Reports, 6. doi: 10.1038/srep32814
2045-2322
10.1038/srep32814
27605389
http://www.nature.com/articles/srep32814
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132472962711552

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