Functionalization and photocuring of an L-lactic acid macromer for biomedical applications

Detalhes bibliográficos
Autor(a) principal: Marques, Dina
Data de Publicação: 2016
Outros Autores: Santos, João, Ferreira, Paula, Correia, Tiago R., Correia, Ilídio Joaquim Sobreira, Gil, Maria, Baptista, Cristina Maria dos Santos Gaudêncio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4679
Resumo: L-lactic acid was the starting material for obtaining bioahesives. Reaction with 1,4-butanediol provided a telechelic lactic acid prepolymer with hydroxyl end groups further functionalized with 2-isocyanatoethyl methacrylate. Films were produced upon UV irradiation, 2 min, after addition of Irgacure 2959. This was a solvent and catalyst free process. Thermal characterization of films confirmed stability at physiological temperature, enabling photocuring. Adhesion properties were assessed with good results. In vitro degradation tests showed moderate hydrolytic instability dependent on thickness. SEM images revealed a uniform and compact structure. Thrombosis tests confirmed the materials’ thrombogenicity while biocompatibility experiments showed fibroblast viability and antimicrobial behavior.
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spelling Functionalization and photocuring of an L-lactic acid macromer for biomedical applicationsBioadhesivesBiocompatibilityBiodegradableL-lactic acidPhotocuringL-lactic acid was the starting material for obtaining bioahesives. Reaction with 1,4-butanediol provided a telechelic lactic acid prepolymer with hydroxyl end groups further functionalized with 2-isocyanatoethyl methacrylate. Films were produced upon UV irradiation, 2 min, after addition of Irgacure 2959. This was a solvent and catalyst free process. Thermal characterization of films confirmed stability at physiological temperature, enabling photocuring. Adhesion properties were assessed with good results. In vitro degradation tests showed moderate hydrolytic instability dependent on thickness. SEM images revealed a uniform and compact structure. Thrombosis tests confirmed the materials’ thrombogenicity while biocompatibility experiments showed fibroblast viability and antimicrobial behavior.Taylor & FrancisuBibliorumMarques, DinaSantos, JoãoFerreira, PaulaCorreia, Tiago R.Correia, Ilídio Joaquim SobreiraGil, MariaBaptista, Cristina Maria dos Santos Gaudêncio2018-03-21T10:28:43Z2016-04-072016-04-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4679engMarques, D.S., Santos, J.M.C., Ferreira, P., Correia, T.R., Correia, I.J., Gil, M.H. e Baptista, C.M.S.G. (2016) "Functionalization and photocuring of a L-lactic acid macromer for biomedical applications", International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 65, pp.497-50710.1080/00914037.2015.1129962metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-07T02:30:51Zoai:ubibliorum.ubi.pt:10400.6/4679Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:44.026318Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
title Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
spellingShingle Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
Marques, Dina
Bioadhesives
Biocompatibility
Biodegradable
L-lactic acid
Photocuring
title_short Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
title_full Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
title_fullStr Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
title_full_unstemmed Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
title_sort Functionalization and photocuring of an L-lactic acid macromer for biomedical applications
author Marques, Dina
author_facet Marques, Dina
Santos, João
Ferreira, Paula
Correia, Tiago R.
Correia, Ilídio Joaquim Sobreira
Gil, Maria
Baptista, Cristina Maria dos Santos Gaudêncio
author_role author
author2 Santos, João
Ferreira, Paula
Correia, Tiago R.
Correia, Ilídio Joaquim Sobreira
Gil, Maria
Baptista, Cristina Maria dos Santos Gaudêncio
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Marques, Dina
Santos, João
Ferreira, Paula
Correia, Tiago R.
Correia, Ilídio Joaquim Sobreira
Gil, Maria
Baptista, Cristina Maria dos Santos Gaudêncio
dc.subject.por.fl_str_mv Bioadhesives
Biocompatibility
Biodegradable
L-lactic acid
Photocuring
topic Bioadhesives
Biocompatibility
Biodegradable
L-lactic acid
Photocuring
description L-lactic acid was the starting material for obtaining bioahesives. Reaction with 1,4-butanediol provided a telechelic lactic acid prepolymer with hydroxyl end groups further functionalized with 2-isocyanatoethyl methacrylate. Films were produced upon UV irradiation, 2 min, after addition of Irgacure 2959. This was a solvent and catalyst free process. Thermal characterization of films confirmed stability at physiological temperature, enabling photocuring. Adhesion properties were assessed with good results. In vitro degradation tests showed moderate hydrolytic instability dependent on thickness. SEM images revealed a uniform and compact structure. Thrombosis tests confirmed the materials’ thrombogenicity while biocompatibility experiments showed fibroblast viability and antimicrobial behavior.
publishDate 2016
dc.date.none.fl_str_mv 2016-04-07
2016-04-07T00:00:00Z
2018-03-21T10:28:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4679
url http://hdl.handle.net/10400.6/4679
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Marques, D.S., Santos, J.M.C., Ferreira, P., Correia, T.R., Correia, I.J., Gil, M.H. e Baptista, C.M.S.G. (2016) "Functionalization and photocuring of a L-lactic acid macromer for biomedical applications", International Journal of Polymeric Materials and Polymeric Biomaterials, Vol. 65, pp.497-507
10.1080/00914037.2015.1129962
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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