Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study.
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://ciencia.iscte-iul.pt/public/pub/id/6148 http://hdl.handle.net/10071/6833 |
Resumo: | Memory complaints are frequent in the elderly but its implications in cognition over time remain a controversial issue. Our objective was to evaluate the risk of self perceived memory complaints in the evolution for future dementia. The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes (WMC) on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Dementia and subtypes of dementia were classified. Self perceived memory complaints in independent elderly were collected during the interview. MRI was performed at entry and at the end of the study. 639 subjects were included (74.1 +/- 5 years old, 55% women, 9.6 +/- 3.8 years of schooling). At end of follow-up, 90 patients were demented (vascular dementia, 54; Alzheimer's disease (AD) and AD with vascular component, 34; frontotemporal dementia, 2). Using Cox regression analysis, we found that self perceived memory complaints were a strong predictor of AD and AD with vascular component during the follow-up (beta = 2.7, p = 0.008; HR = 15.5, CI 95% [2.04, 117.6]), independently of other confounders, namely depressive symptoms, WMC severity, medial temporal lobe atrophy, and global cognition status at baseline. Self perceived memory complaints did not predict vascular dementia. In the LADIS study, self perceived memory complaints predicted AD but not vascular dementia in elderly subjects with WMC living independently. |
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Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study.AgingAlzheimer's diseaseDementiaMemory complaintsWhite matter changesMemory complaints are frequent in the elderly but its implications in cognition over time remain a controversial issue. Our objective was to evaluate the risk of self perceived memory complaints in the evolution for future dementia. The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes (WMC) on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Dementia and subtypes of dementia were classified. Self perceived memory complaints in independent elderly were collected during the interview. MRI was performed at entry and at the end of the study. 639 subjects were included (74.1 +/- 5 years old, 55% women, 9.6 +/- 3.8 years of schooling). At end of follow-up, 90 patients were demented (vascular dementia, 54; Alzheimer's disease (AD) and AD with vascular component, 34; frontotemporal dementia, 2). Using Cox regression analysis, we found that self perceived memory complaints were a strong predictor of AD and AD with vascular component during the follow-up (beta = 2.7, p = 0.008; HR = 15.5, CI 95% [2.04, 117.6]), independently of other confounders, namely depressive symptoms, WMC severity, medial temporal lobe atrophy, and global cognition status at baseline. Self perceived memory complaints did not predict vascular dementia. In the LADIS study, self perceived memory complaints predicted AD but not vascular dementia in elderly subjects with WMC living independently.IOS Press2014-03-31T15:31:00Z2011-01-01T00:00:00Z20112014-03-31T15:27:30Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://ciencia.iscte-iul.pt/public/pub/id/6148http://hdl.handle.net/10071/6833eng1387-2877Verdelho, A.Madureira, S.Moleiro, C.Santos, A.C.Ferro, J.Erkinjuntti, T.Poggesi, A.Pantoni, L.Fazekas, F.Scheltens, P.Waldemar, G.Wallin, A.Inzitari, D.on behalf of the LADIS Studyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-09T17:27:41Zoai:repositorio.iscte-iul.pt:10071/6833Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:12:20.825039Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
title |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
spellingShingle |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. Verdelho, A. Aging Alzheimer's disease Dementia Memory complaints White matter changes |
title_short |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
title_full |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
title_fullStr |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
title_full_unstemmed |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
title_sort |
Self-perceived memory complaints predict progression to Alzheimer disease: The LADIS study. |
author |
Verdelho, A. |
author_facet |
Verdelho, A. Madureira, S. Moleiro, C. Santos, A.C. Ferro, J. Erkinjuntti, T. Poggesi, A. Pantoni, L. Fazekas, F. Scheltens, P. Waldemar, G. Wallin, A. Inzitari, D. on behalf of the LADIS Study |
author_role |
author |
author2 |
Madureira, S. Moleiro, C. Santos, A.C. Ferro, J. Erkinjuntti, T. Poggesi, A. Pantoni, L. Fazekas, F. Scheltens, P. Waldemar, G. Wallin, A. Inzitari, D. on behalf of the LADIS Study |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Verdelho, A. Madureira, S. Moleiro, C. Santos, A.C. Ferro, J. Erkinjuntti, T. Poggesi, A. Pantoni, L. Fazekas, F. Scheltens, P. Waldemar, G. Wallin, A. Inzitari, D. on behalf of the LADIS Study |
dc.subject.por.fl_str_mv |
Aging Alzheimer's disease Dementia Memory complaints White matter changes |
topic |
Aging Alzheimer's disease Dementia Memory complaints White matter changes |
description |
Memory complaints are frequent in the elderly but its implications in cognition over time remain a controversial issue. Our objective was to evaluate the risk of self perceived memory complaints in the evolution for future dementia. The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes (WMC) on the transition of independent elderly subjects into disability. Independent elderly were enrolled due to the presence of WMC. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and a neuropsychological battery. Dementia and subtypes of dementia were classified. Self perceived memory complaints in independent elderly were collected during the interview. MRI was performed at entry and at the end of the study. 639 subjects were included (74.1 +/- 5 years old, 55% women, 9.6 +/- 3.8 years of schooling). At end of follow-up, 90 patients were demented (vascular dementia, 54; Alzheimer's disease (AD) and AD with vascular component, 34; frontotemporal dementia, 2). Using Cox regression analysis, we found that self perceived memory complaints were a strong predictor of AD and AD with vascular component during the follow-up (beta = 2.7, p = 0.008; HR = 15.5, CI 95% [2.04, 117.6]), independently of other confounders, namely depressive symptoms, WMC severity, medial temporal lobe atrophy, and global cognition status at baseline. Self perceived memory complaints did not predict vascular dementia. In the LADIS study, self perceived memory complaints predicted AD but not vascular dementia in elderly subjects with WMC living independently. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01T00:00:00Z 2011 2014-03-31T15:31:00Z 2014-03-31T15:27:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ciencia.iscte-iul.pt/public/pub/id/6148 http://hdl.handle.net/10071/6833 |
url |
https://ciencia.iscte-iul.pt/public/pub/id/6148 http://hdl.handle.net/10071/6833 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1387-2877 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
IOS Press |
publisher.none.fl_str_mv |
IOS Press |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134678709436416 |