Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines

Detalhes bibliográficos
Autor(a) principal: Resende, Diana I. S. P.
Data de Publicação: 2015
Outros Autores: Guieu, Samuel, Oliva, Cristina G., Silva, Artur M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/18209
Resumo: A general and efficient asymmetric synthesis of Δ1-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5- diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The Δ1-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%).
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spelling Efficient Synthesis of Highly Enantioenriched Delta(1)-PyrrolinesPyrrolinesReductive cyclizationMichael additionSstereoselectivityA general and efficient asymmetric synthesis of Δ1-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5- diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The Δ1-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%).Thieme Publishing2017-08-02T13:59:49Z2015-01-01T00:00:00Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/18209eng1437-209610.1055/s-0034-1380144Resende, Diana I. S. P.Guieu, SamuelOliva, Cristina G.Silva, Artur M. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:33:38Zoai:ria.ua.pt:10773/18209Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:52:40.505772Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
title Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
spellingShingle Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
Resende, Diana I. S. P.
Pyrrolines
Reductive cyclization
Michael addition
Sstereoselectivity
title_short Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
title_full Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
title_fullStr Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
title_full_unstemmed Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
title_sort Efficient Synthesis of Highly Enantioenriched Delta(1)-Pyrrolines
author Resende, Diana I. S. P.
author_facet Resende, Diana I. S. P.
Guieu, Samuel
Oliva, Cristina G.
Silva, Artur M. S.
author_role author
author2 Guieu, Samuel
Oliva, Cristina G.
Silva, Artur M. S.
author2_role author
author
author
dc.contributor.author.fl_str_mv Resende, Diana I. S. P.
Guieu, Samuel
Oliva, Cristina G.
Silva, Artur M. S.
dc.subject.por.fl_str_mv Pyrrolines
Reductive cyclization
Michael addition
Sstereoselectivity
topic Pyrrolines
Reductive cyclization
Michael addition
Sstereoselectivity
description A general and efficient asymmetric synthesis of Δ1-pyrrolines by a one-pot nitro-reduction, cyclization, and dehydration of (R,E)-1,5- diphenyl-3-(nitromethyl)-5-pent-4-en-1-ones with iron and aqueous hydrochloric acid has been developed. The Δ1-pyrrolines were obtained with excellent enantioselectivities (up to 99%) and high yields (up to 83%).
publishDate 2015
dc.date.none.fl_str_mv 2015-01-01T00:00:00Z
2015
2017-08-02T13:59:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/18209
url http://hdl.handle.net/10773/18209
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1437-2096
10.1055/s-0034-1380144
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Thieme Publishing
publisher.none.fl_str_mv Thieme Publishing
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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