Do bone mineral content and density determine fracture in children? A possible threshold for physical activity

Detalhes bibliográficos
Autor(a) principal: Martins, Ana
Data de Publicação: 2017
Outros Autores: Monjardino, Teresa, Nogueira, Luísa, Canhão, Helena, Lucas, Raquel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/151565
Resumo: Funding: Generation XXI was funded by FEDER through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education; POCI-01-0145-FEDER-016838 and POCI-01-0145-FEDER-016837), under the projects “BioAdversity: Como a adversidade social na infância condiciona a saúde: A biologia da adversidade social” (Ref. FCT PTDC/DTP-EPI/1687/2014) and “PathMOB.: Risco cardiometabólico na infância: desde o início da vida ao fim da infância” (Ref. FCT PTDC/DTP-EPI/3306/2014); by the Unidade de Investigação em Epidemiologia—Instituto de Saúde Pública da Universidade do Porto (EPIUnit; POCI-01-0145-FEDER-006862; Ref. UID/DTP/ 04750/2013); and by Administração Regional de Saúde Norte (Regional Department of Ministry of Health) and Fundação Calouste Gulbenkian; PhD grant SFRH/BD/92370/2013 (T.M.) and postdoc grant SFRH/BPD/ 88729/2012 (R.L.), co-funded by FCT and the POPH/FSE Program; and an MSD merit scholarship attributed to the Masters in Public Health of Universidade do Porto (A.M.). This study is also a result of the project DOCnet (NORTE-01-0145-FEDER-000003), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).
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spelling Do bone mineral content and density determine fracture in children? A possible threshold for physical activityPediatrics, Perinatology, and Child HealthFunding: Generation XXI was funded by FEDER through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education; POCI-01-0145-FEDER-016838 and POCI-01-0145-FEDER-016837), under the projects “BioAdversity: Como a adversidade social na infância condiciona a saúde: A biologia da adversidade social” (Ref. FCT PTDC/DTP-EPI/1687/2014) and “PathMOB.: Risco cardiometabólico na infância: desde o início da vida ao fim da infância” (Ref. FCT PTDC/DTP-EPI/3306/2014); by the Unidade de Investigação em Epidemiologia—Instituto de Saúde Pública da Universidade do Porto (EPIUnit; POCI-01-0145-FEDER-006862; Ref. UID/DTP/ 04750/2013); and by Administração Regional de Saúde Norte (Regional Department of Ministry of Health) and Fundação Calouste Gulbenkian; PhD grant SFRH/BD/92370/2013 (T.M.) and postdoc grant SFRH/BPD/ 88729/2012 (R.L.), co-funded by FCT and the POPH/FSE Program; and an MSD merit scholarship attributed to the Masters in Public Health of Universidade do Porto (A.M.). This study is also a result of the project DOCnet (NORTE-01-0145-FEDER-000003), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).BackgroundRelations between bone parameters, physical exertion, and childhood fractures are complex. We aimed to estimate the associations between fracture history and bone mineral content (BMC) and areal bone mineral density (aBMD) at 7 years of age, by levels of physical activity, as a proxy for trauma frequency.MethodsWe used data collected from 2,261 children of the Generation XXI birth cohort, assembled in 2005/6 in Porto, Portugal. At the age of 7 years (2012/4), fracture history, time spent per week in active play, and sports practice were reported by parents. Subtotal and lumbar spine (LS) BMC and aBMD were measured using whole-body dual-energy X-ray absorptiometry.ResultsBoys and girls in the highest categories of time spent in sports practice or active play generally had higher BMC and aBMD. Among girls, BMC and aBMD were protective of fracture only in the highest quarter of active play (>660 min/week) - odds ratios (OR; 95% confidence interval (95% CI)) for subtotal BMC=0.27 (0.11-0.67), subtotal aBMD=0.18 (0.06-0.49), and LS aBMD=0.41 (0.22-0.75). For boys in the highest quarter of sports practice (>240 min/week), subtotal and LS BMC were protective of fracture - OR=0.39 (0.16-0.98) and 0.51 (0.27-0.96), respectively.ConclusionIn prepubertal children, BMC and aBMD predicted fracture history only in the highest levels of physical activity.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Estudos de Doenças Crónicas (CEDOC)RUNMartins, AnaMonjardino, TeresaNogueira, LuísaCanhão, HelenaLucas, Raquel2023-04-04T22:09:55Z2017-09-012017-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/151565eng0031-3998PURE: 3094397https://doi.org/10.1038/pr.2017.113info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:34:00Zoai:run.unl.pt:10362/151565Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:38.392290Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
title Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
spellingShingle Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
Martins, Ana
Pediatrics, Perinatology, and Child Health
title_short Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
title_full Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
title_fullStr Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
title_full_unstemmed Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
title_sort Do bone mineral content and density determine fracture in children? A possible threshold for physical activity
author Martins, Ana
author_facet Martins, Ana
Monjardino, Teresa
Nogueira, Luísa
Canhão, Helena
Lucas, Raquel
author_role author
author2 Monjardino, Teresa
Nogueira, Luísa
Canhão, Helena
Lucas, Raquel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centro de Estudos de Doenças Crónicas (CEDOC)
RUN
dc.contributor.author.fl_str_mv Martins, Ana
Monjardino, Teresa
Nogueira, Luísa
Canhão, Helena
Lucas, Raquel
dc.subject.por.fl_str_mv Pediatrics, Perinatology, and Child Health
topic Pediatrics, Perinatology, and Child Health
description Funding: Generation XXI was funded by FEDER through the Operational Programme Competitiveness and Internationalization and national funding from the Foundation for Science and Technology—FCT (Portuguese Ministry of Science, Technology and Higher Education; POCI-01-0145-FEDER-016838 and POCI-01-0145-FEDER-016837), under the projects “BioAdversity: Como a adversidade social na infância condiciona a saúde: A biologia da adversidade social” (Ref. FCT PTDC/DTP-EPI/1687/2014) and “PathMOB.: Risco cardiometabólico na infância: desde o início da vida ao fim da infância” (Ref. FCT PTDC/DTP-EPI/3306/2014); by the Unidade de Investigação em Epidemiologia—Instituto de Saúde Pública da Universidade do Porto (EPIUnit; POCI-01-0145-FEDER-006862; Ref. UID/DTP/ 04750/2013); and by Administração Regional de Saúde Norte (Regional Department of Ministry of Health) and Fundação Calouste Gulbenkian; PhD grant SFRH/BD/92370/2013 (T.M.) and postdoc grant SFRH/BPD/ 88729/2012 (R.L.), co-funded by FCT and the POPH/FSE Program; and an MSD merit scholarship attributed to the Masters in Public Health of Universidade do Porto (A.M.). This study is also a result of the project DOCnet (NORTE-01-0145-FEDER-000003), supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
2017-09-01T00:00:00Z
2023-04-04T22:09:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/151565
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 0031-3998
PURE: 3094397
https://doi.org/10.1038/pr.2017.113
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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