Recent advances of metallocenes for medicinal chemistry

Detalhes bibliográficos
Autor(a) principal: Santos, Miguel M.
Data de Publicação: 2017
Outros Autores: Bastos, Pedro, Catela, Isabelle, Zalewska, Karolina, Branco, Luis C.
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/99962
Resumo: This work was supported by LAQV-REQUIMTE; Fundacao para a Ciencia e Tecnologia (FCT, Portugal), through projects and the IF researcher consolidator contract (IF/0041/2013/CP1161/CT005), and Solchemar Company.
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spelling Recent advances of metallocenes for medicinal chemistryAnti-HIVAnti-malariaAnti-tumoralFerrocene derivativesMedicinal chemistryMetallocenesMolecular MedicinePharmacologyDrug DiscoveryCancer ResearchSDG 3 - Good Health and Well-beingThis work was supported by LAQV-REQUIMTE; Fundacao para a Ciencia e Tecnologia (FCT, Portugal), through projects and the IF researcher consolidator contract (IF/0041/2013/CP1161/CT005), and Solchemar Company.Background: The recent advances for the synthesis and application of different metallocenes for Medicinal Chemistry is reviewed. Objective: This manuscript presents the different metallocene scaffolds, with special emphasis on ferrocene derivatives, and their potential pharmaceutical application. Over the last years, the synthesis of new metallocene compounds and their biological and medicinal effects against some types of diseases (e.g. anti-tumoral, antibiotics, anti-viral) have been reported. From the medicinal point of view, the attractive properties of metallocene derivatives, such as their high stability, low toxicity and appealing redox behaviors are particularly relevant. Results: This area has attracted many researchers as well as the pharmaceutical industry due to the promising results of some metallocenes, in particular ferrocene compounds, in breast cancer and malaria.LAQV@REQUIMTEDQ - Departamento de QuímicaRUNSantos, Miguel M.Bastos, PedroCatela, IsabelleZalewska, KarolinaBranco, Luis C.2020-06-25T23:09:50Z20172017-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other14application/pdfhttp://hdl.handle.net/10362/99962eng1389-5575PURE: 18448383https://doi.org/10.2174/1389557516666161031141620info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:46:14Zoai:run.unl.pt:10362/99962Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:46:14Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Recent advances of metallocenes for medicinal chemistry
title Recent advances of metallocenes for medicinal chemistry
spellingShingle Recent advances of metallocenes for medicinal chemistry
Santos, Miguel M.
Anti-HIV
Anti-malaria
Anti-tumoral
Ferrocene derivatives
Medicinal chemistry
Metallocenes
Molecular Medicine
Pharmacology
Drug Discovery
Cancer Research
SDG 3 - Good Health and Well-being
title_short Recent advances of metallocenes for medicinal chemistry
title_full Recent advances of metallocenes for medicinal chemistry
title_fullStr Recent advances of metallocenes for medicinal chemistry
title_full_unstemmed Recent advances of metallocenes for medicinal chemistry
title_sort Recent advances of metallocenes for medicinal chemistry
author Santos, Miguel M.
author_facet Santos, Miguel M.
Bastos, Pedro
Catela, Isabelle
Zalewska, Karolina
Branco, Luis C.
author_role author
author2 Bastos, Pedro
Catela, Isabelle
Zalewska, Karolina
Branco, Luis C.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv LAQV@REQUIMTE
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Santos, Miguel M.
Bastos, Pedro
Catela, Isabelle
Zalewska, Karolina
Branco, Luis C.
dc.subject.por.fl_str_mv Anti-HIV
Anti-malaria
Anti-tumoral
Ferrocene derivatives
Medicinal chemistry
Metallocenes
Molecular Medicine
Pharmacology
Drug Discovery
Cancer Research
SDG 3 - Good Health and Well-being
topic Anti-HIV
Anti-malaria
Anti-tumoral
Ferrocene derivatives
Medicinal chemistry
Metallocenes
Molecular Medicine
Pharmacology
Drug Discovery
Cancer Research
SDG 3 - Good Health and Well-being
description This work was supported by LAQV-REQUIMTE; Fundacao para a Ciencia e Tecnologia (FCT, Portugal), through projects and the IF researcher consolidator contract (IF/0041/2013/CP1161/CT005), and Solchemar Company.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01T00:00:00Z
2020-06-25T23:09:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/99962
url http://hdl.handle.net/10362/99962
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1389-5575
PURE: 18448383
https://doi.org/10.2174/1389557516666161031141620
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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