Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel

Detalhes bibliográficos
Autor(a) principal: Sousa-Pimenta, Mário
Data de Publicação: 2023
Outros Autores: Estevinho, Leticia M., Szopa, Agnieszka, Basit, Mahnoor, Khan, Khushbukhat, Armaghan, Muhammad, Ibrayeva, Manshuk, Gurer, Eda Sonmez, Calina, Daniela, Hano, Christophe, Sharifi-Rad, Javad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/28528
Resumo: Over the years, many biological and synthetic agents have been explored and tested in attempts to halt the spread of cancer and/or cure it. Currently, several natural compounds have and are being considered in this regard. For example, paclitaxel is a potent anticancer drug that originates from the tree Taxus brevifolia. Paclitaxel has several derivatives, namely, docetaxel and cabazitaxel. These agents work by disrupting microtubule assembling dynamics and inducing cell cycle arrest at the G2/M phase of the cell cycle, ultimately triggering apoptosis. Such features have helped to establish paclitaxel as an authoritative therapeutic compound against neoplastic disorders. After the completion of compound (hemi) synthesis, this drug received approval for the treatment of solid tumors either alone or in combination with other agents. In this review, we explore the mechanisms of action of paclitaxel and its derivatives, the different formulations available, as well as the molecular pathways of cancer resistance, potential risks, and other therapeutic applications. In addition, the role of paclitaxel in hematological malignancies is explored, and potential limitations in the therapeutic use of paclitaxel at the clinical level are examined. Furthermore, paclitaxel is known to cause increased antigen presentation. The immunomodulatory potential of taxanes, alone or in combination with other pharmacologic agents, is explored. Despite terpene-alkaloids derivatives' anti-mitotic potential, the impact of this class of drugs on other oncogenic pathways, such as epithelial-to-mesenchymal transition and the epigenetic modulation of the transcription profile of cancer cells, is also analyzed, shedding light on potential future chemotherapeutic approaches to cancer.
id RCAP_39e49f77a54520545b61fe4c19e63079
oai_identifier_str oai:bibliotecadigital.ipb.pt:10198/28528
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxelPaclitaxelDocetaxelCabazitaxelToxoidsTaxus brevifoliaAnticancer mechanismsOver the years, many biological and synthetic agents have been explored and tested in attempts to halt the spread of cancer and/or cure it. Currently, several natural compounds have and are being considered in this regard. For example, paclitaxel is a potent anticancer drug that originates from the tree Taxus brevifolia. Paclitaxel has several derivatives, namely, docetaxel and cabazitaxel. These agents work by disrupting microtubule assembling dynamics and inducing cell cycle arrest at the G2/M phase of the cell cycle, ultimately triggering apoptosis. Such features have helped to establish paclitaxel as an authoritative therapeutic compound against neoplastic disorders. After the completion of compound (hemi) synthesis, this drug received approval for the treatment of solid tumors either alone or in combination with other agents. In this review, we explore the mechanisms of action of paclitaxel and its derivatives, the different formulations available, as well as the molecular pathways of cancer resistance, potential risks, and other therapeutic applications. In addition, the role of paclitaxel in hematological malignancies is explored, and potential limitations in the therapeutic use of paclitaxel at the clinical level are examined. Furthermore, paclitaxel is known to cause increased antigen presentation. The immunomodulatory potential of taxanes, alone or in combination with other pharmacologic agents, is explored. Despite terpene-alkaloids derivatives' anti-mitotic potential, the impact of this class of drugs on other oncogenic pathways, such as epithelial-to-mesenchymal transition and the epigenetic modulation of the transcription profile of cancer cells, is also analyzed, shedding light on potential future chemotherapeutic approaches to cancer.FrontiersBiblioteca Digital do IPBSousa-Pimenta, MárioEstevinho, Leticia M.Szopa, AgnieszkaBasit, MahnoorKhan, KhushbukhatArmaghan, MuhammadIbrayeva, ManshukGurer, Eda SonmezCalina, DanielaHano, ChristopheSharifi-Rad, Javad2023-07-13T16:10:21Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/28528engSousa-Pimenta, Mário; Estevinho, Leticia M.; Szopa, Agnieszka; Basit, Mahnoor; Khan, Khushbukhat; Armaghan, Muhammad; Ibrayeva, Manshuk; Gurer, Eda Sonmez; Calina, Daniela; Hano, Christophe; Sharifi-Rad, Javad (2023). Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel. Frontiers in Pharmacology. eISSN 1663-9812. 14, p. 1-1410.3389/fphar.2023.11573061663-9812info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T11:02:29Zoai:bibliotecadigital.ipb.pt:10198/28528Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:18:31.873914Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
title Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
spellingShingle Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
Sousa-Pimenta, Mário
Paclitaxel
Docetaxel
Cabazitaxel
Toxoids
Taxus brevifolia
Anticancer mechanisms
title_short Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
title_full Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
title_fullStr Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
title_full_unstemmed Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
title_sort Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel
author Sousa-Pimenta, Mário
author_facet Sousa-Pimenta, Mário
Estevinho, Leticia M.
Szopa, Agnieszka
Basit, Mahnoor
Khan, Khushbukhat
Armaghan, Muhammad
Ibrayeva, Manshuk
Gurer, Eda Sonmez
Calina, Daniela
Hano, Christophe
Sharifi-Rad, Javad
author_role author
author2 Estevinho, Leticia M.
Szopa, Agnieszka
Basit, Mahnoor
Khan, Khushbukhat
Armaghan, Muhammad
Ibrayeva, Manshuk
Gurer, Eda Sonmez
Calina, Daniela
Hano, Christophe
Sharifi-Rad, Javad
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Sousa-Pimenta, Mário
Estevinho, Leticia M.
Szopa, Agnieszka
Basit, Mahnoor
Khan, Khushbukhat
Armaghan, Muhammad
Ibrayeva, Manshuk
Gurer, Eda Sonmez
Calina, Daniela
Hano, Christophe
Sharifi-Rad, Javad
dc.subject.por.fl_str_mv Paclitaxel
Docetaxel
Cabazitaxel
Toxoids
Taxus brevifolia
Anticancer mechanisms
topic Paclitaxel
Docetaxel
Cabazitaxel
Toxoids
Taxus brevifolia
Anticancer mechanisms
description Over the years, many biological and synthetic agents have been explored and tested in attempts to halt the spread of cancer and/or cure it. Currently, several natural compounds have and are being considered in this regard. For example, paclitaxel is a potent anticancer drug that originates from the tree Taxus brevifolia. Paclitaxel has several derivatives, namely, docetaxel and cabazitaxel. These agents work by disrupting microtubule assembling dynamics and inducing cell cycle arrest at the G2/M phase of the cell cycle, ultimately triggering apoptosis. Such features have helped to establish paclitaxel as an authoritative therapeutic compound against neoplastic disorders. After the completion of compound (hemi) synthesis, this drug received approval for the treatment of solid tumors either alone or in combination with other agents. In this review, we explore the mechanisms of action of paclitaxel and its derivatives, the different formulations available, as well as the molecular pathways of cancer resistance, potential risks, and other therapeutic applications. In addition, the role of paclitaxel in hematological malignancies is explored, and potential limitations in the therapeutic use of paclitaxel at the clinical level are examined. Furthermore, paclitaxel is known to cause increased antigen presentation. The immunomodulatory potential of taxanes, alone or in combination with other pharmacologic agents, is explored. Despite terpene-alkaloids derivatives' anti-mitotic potential, the impact of this class of drugs on other oncogenic pathways, such as epithelial-to-mesenchymal transition and the epigenetic modulation of the transcription profile of cancer cells, is also analyzed, shedding light on potential future chemotherapeutic approaches to cancer.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-13T16:10:21Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/28528
url http://hdl.handle.net/10198/28528
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sousa-Pimenta, Mário; Estevinho, Leticia M.; Szopa, Agnieszka; Basit, Mahnoor; Khan, Khushbukhat; Armaghan, Muhammad; Ibrayeva, Manshuk; Gurer, Eda Sonmez; Calina, Daniela; Hano, Christophe; Sharifi-Rad, Javad (2023). Chemotherapeutic properties and side-effects associated with the clinical practice of terpene alkaloids: paclitaxel, docetaxel, and cabazitaxel. Frontiers in Pharmacology. eISSN 1663-9812. 14, p. 1-14
10.3389/fphar.2023.1157306
1663-9812
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799135481581010944