Advances in understanding molecular regulation of innate immune memory
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/49906 |
Resumo: | © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
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Advances in understanding molecular regulation of innate immune memoryEpigeneticsInnate memoryMacrophagesMetabolismMonocytesStem cellsTADsTrained immunitylncRNA© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).The epigenetic and functional reprogramming of immune genes during induction of trained immunity is accompanied by the metabolic rewiring of cellular state. This memory is induced in the hematopoietic niche and propagated to daughter cells, generating epigenetically and metabolically reprogrammed innate immune cells that are greatly enhanced in their capacity to resolve inflammation. In particular, these cells show accumulation of H3K4me3 and H3K27Ac epigenetic marks on multiple immune gene promoters and associated enhancers. However, the mechanism governing how these epigenetic marks accumulate at discrete immune gene loci has been poorly understood, until now. Here, we discuss some recent advances in the regulation of trained immunity, with a particular focus on the mechanistic role of a novel class of long non-coding RNAs in the establishment of epigenetic marks on trained immune gene promoters.M.G.N. was supported by a Spinoza Grant of the Netherlands Organization for Scientific Research. L.A.B.J. was supported by a Competitiveness Operational Program grant of the Romanian Ministry of European Funds (HINT, ID P_37_762; MySMIS 103587). M.M.M. research is supported by a Department of Science and Technology Centre of Competence Grant, an SA Medical Research Council SHIP grant, and a CSIR Parliamentary Grant, all to M.M.M, and M.M.M. is a Chan Zuckerberg Investigator of the Chan Zuckerberg Initiative.ElsevierRepositório da Universidade de LisboaDomínguez-Andrés, JorgeFanucchi, StephanieJoosten, Leo A.B.Mhlanga, MusaNetea, Mihai G.2021-10-15T13:40:18Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49906engCurr Opin Cell Biol. 2020 Apr;63:68-750955-067410.1016/j.ceb.2019.12.0061879-0410info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:52Zoai:repositorio.ul.pt:10451/49906Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:26.052665Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Advances in understanding molecular regulation of innate immune memory |
title |
Advances in understanding molecular regulation of innate immune memory |
spellingShingle |
Advances in understanding molecular regulation of innate immune memory Domínguez-Andrés, Jorge Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
title_short |
Advances in understanding molecular regulation of innate immune memory |
title_full |
Advances in understanding molecular regulation of innate immune memory |
title_fullStr |
Advances in understanding molecular regulation of innate immune memory |
title_full_unstemmed |
Advances in understanding molecular regulation of innate immune memory |
title_sort |
Advances in understanding molecular regulation of innate immune memory |
author |
Domínguez-Andrés, Jorge |
author_facet |
Domínguez-Andrés, Jorge Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
author_role |
author |
author2 |
Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Domínguez-Andrés, Jorge Fanucchi, Stephanie Joosten, Leo A.B. Mhlanga, Musa Netea, Mihai G. |
dc.subject.por.fl_str_mv |
Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
topic |
Epigenetics Innate memory Macrophages Metabolism Monocytes Stem cells TADs Trained immunity lncRNA |
description |
© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-10-15T13:40:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/49906 |
url |
http://hdl.handle.net/10451/49906 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Curr Opin Cell Biol. 2020 Apr;63:68-75 0955-0674 10.1016/j.ceb.2019.12.006 1879-0410 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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