Biological microsystem for measuring uric acid in biological fluids

Detalhes bibliográficos
Autor(a) principal: Minas, Graça
Data de Publicação: 2004
Outros Autores: Martins, Júlio S., Ribeiro, J. C., Wolffenbuttel, R. F., Correia, J. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/1986
Resumo: This paper describes a biological microsystem (bio-system) for measuring uric acid concentration in serum, plasma or urine. Its operation is based on optical absorption in a well-defined part of the visible spectrum. The bio-system is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated in a CMOS standard process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14µl of infinity™ uric acid reagent with 0.25µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of the value in urine of a healthy person), with a 1mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected. This bio-system can be included in the group of low-cost disposable devices for biological fluids analysis.
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spelling Biological microsystem for measuring uric acid in biological fluidsBio-systemUric acidOptical absorptionScience & TechnologyThis paper describes a biological microsystem (bio-system) for measuring uric acid concentration in serum, plasma or urine. Its operation is based on optical absorption in a well-defined part of the visible spectrum. The bio-system is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated in a CMOS standard process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14µl of infinity™ uric acid reagent with 0.25µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of the value in urine of a healthy person), with a 1mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected. This bio-system can be included in the group of low-cost disposable devices for biological fluids analysis.Fundação para a Ciência e a Tecnologia (FCT) - SFRH/BD/1281/2000, POCTI/33747/ESE/1999), FEDER.ElsevierUniversidade do MinhoMinas, GraçaMartins, Júlio S.Ribeiro, J. C.Wolffenbuttel, R. F.Correia, J. H.20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/1986eng"Sensors and Actuators A : Physical". ISSN 0924-4247. 110 (2004) 33-38.0924-424710.1016/j.sna.2003.10.049info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:11Zoai:repositorium.sdum.uminho.pt:1822/1986Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:14.133961Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biological microsystem for measuring uric acid in biological fluids
title Biological microsystem for measuring uric acid in biological fluids
spellingShingle Biological microsystem for measuring uric acid in biological fluids
Minas, Graça
Bio-system
Uric acid
Optical absorption
Science & Technology
title_short Biological microsystem for measuring uric acid in biological fluids
title_full Biological microsystem for measuring uric acid in biological fluids
title_fullStr Biological microsystem for measuring uric acid in biological fluids
title_full_unstemmed Biological microsystem for measuring uric acid in biological fluids
title_sort Biological microsystem for measuring uric acid in biological fluids
author Minas, Graça
author_facet Minas, Graça
Martins, Júlio S.
Ribeiro, J. C.
Wolffenbuttel, R. F.
Correia, J. H.
author_role author
author2 Martins, Júlio S.
Ribeiro, J. C.
Wolffenbuttel, R. F.
Correia, J. H.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Minas, Graça
Martins, Júlio S.
Ribeiro, J. C.
Wolffenbuttel, R. F.
Correia, J. H.
dc.subject.por.fl_str_mv Bio-system
Uric acid
Optical absorption
Science & Technology
topic Bio-system
Uric acid
Optical absorption
Science & Technology
description This paper describes a biological microsystem (bio-system) for measuring uric acid concentration in serum, plasma or urine. Its operation is based on optical absorption in a well-defined part of the visible spectrum. The bio-system is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated in a CMOS standard process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14µl of infinity™ uric acid reagent with 0.25µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of the value in urine of a healthy person), with a 1mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected. This bio-system can be included in the group of low-cost disposable devices for biological fluids analysis.
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/1986
url http://hdl.handle.net/1822/1986
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv "Sensors and Actuators A : Physical". ISSN 0924-4247. 110 (2004) 33-38.
0924-4247
10.1016/j.sna.2003.10.049
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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