Repairing thymic function

Detalhes bibliográficos
Autor(a) principal: Nunes-Cabaço, H.
Data de Publicação: 2013
Outros Autores: Sousa, A. E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/18298
Resumo: © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
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spelling Repairing thymic function© 2013 Wolters Kluwer Health | Lippincott Williams & WilkinsPurpose of review: Maintenance of T-cell function and modulation of tolerance are critical issues in organ transplantation. The thymus is the primary organ for T-cell generation, and a preserved thymic function is essential for a self-tolerant diverse T-cell repertoire. Transplant procedures and related immunosuppressive drugs may hinder thymic integrity and function. We review here the recent advances in understanding the regulation of the unique thymic microenvironment with relevance for the field of transplantation. Recent findings: Recent studies have assigned a role for IL-22 in the regeneration of thymic epithelium, and for microRNAs in the modulation of its survival and function. The interplay of key molecules in the cross-talk between thymic epithelial cells and thymocytes was depicted, opening new perspectives for the in-vitro recapitulation of T-cell development and for thymic transplantation. Additionally, the thymus was shown to be able to sustain thymocyte progenitor renewal. Summary: These findings open new venues of research toward therapeutic interventions in the endogenous thymus to modulate or reconstitute the immune system; thymic transplantation; and the future development of artificial thymus, which would represent an important tool to achieve tolerance across the histocompatibility barriers.Lippincott Williams & WilkinsRepositório da Universidade de LisboaNunes-Cabaço, H.Sousa, A. E.2015-06-17T11:40:41Z2013-062013-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/18298engCurrent Opinion in Organ Transplantation, Volume 18 - Issue 3 - p 363–3681087-2418http://dx.doi.org/10.1097/MOT.0b013e3283615df9info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:04:31Zoai:repositorio.ul.pt:10451/18298Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:54.113192Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Repairing thymic function
title Repairing thymic function
spellingShingle Repairing thymic function
Nunes-Cabaço, H.
title_short Repairing thymic function
title_full Repairing thymic function
title_fullStr Repairing thymic function
title_full_unstemmed Repairing thymic function
title_sort Repairing thymic function
author Nunes-Cabaço, H.
author_facet Nunes-Cabaço, H.
Sousa, A. E.
author_role author
author2 Sousa, A. E.
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Nunes-Cabaço, H.
Sousa, A. E.
description © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins
publishDate 2013
dc.date.none.fl_str_mv 2013-06
2013-06-01T00:00:00Z
2015-06-17T11:40:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/18298
url http://hdl.handle.net/10451/18298
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Current Opinion in Organ Transplantation, Volume 18 - Issue 3 - p 363–368
1087-2418
http://dx.doi.org/10.1097/MOT.0b013e3283615df9
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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