Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/59208 |
Resumo: | Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA). |
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Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Reviewtitanium dioxide nanoparticleshuman exposureingested TIO2-NPsAOPnanosafetycolorectal canceradverse outcomesTitanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA).This research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics (UIDP/00009/2020; UIDB/00009/2020), iMed.ULisboa (UIDB/04138/2020+UIDP/04138/2020), CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and BioISI (UID/MULTI/04046/2019). N.V. thanks the Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia, e Ensino Superior, for her PhD grant 2020.07168.BD. L.G. was supported by FCT Individual CEEC as a Principal Researcher Grant (CEECIND/03143/2017) and R.A. as an Assistant Researcher Grant (CEECIND/01570/2018).MDPIRepositório da Universidade de LisboaRolo, DoraAssunção, RicardoVentura, CéliaAlvito, PaulaGonçalves, LídiaMartins, CarlaBettencourt, AnaJordan, PeterVital, NádiaPereira, JoanaPinto, FátimaMatos, PauloSilva, Maria JoãoLouro, Henriqueta2023-09-11T16:38:36Z2022-09-212023-02-27T14:52:18Z2022-09-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/59208engRolo D, Assunção R, Ventura C, Alvito P, Gonçalves L, Martins C, et al. Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials [Internet]. 2022 Sep 21;12(19):3275. Available from: http://dx.doi.org/10.3390/nano12193275cv-prod-314755110.3390/nano12193275info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:04:03Zoai:repositorio.ul.pt:10451/59208Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:59.358378Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
title |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
spellingShingle |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review Rolo, Dora titanium dioxide nanoparticles human exposure ingested TIO2-NPs AOP nanosafety colorectal cancer adverse outcomes |
title_short |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
title_full |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
title_fullStr |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
title_full_unstemmed |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
title_sort |
Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review |
author |
Rolo, Dora |
author_facet |
Rolo, Dora Assunção, Ricardo Ventura, Célia Alvito, Paula Gonçalves, Lídia Martins, Carla Bettencourt, Ana Jordan, Peter Vital, Nádia Pereira, Joana Pinto, Fátima Matos, Paulo Silva, Maria João Louro, Henriqueta |
author_role |
author |
author2 |
Assunção, Ricardo Ventura, Célia Alvito, Paula Gonçalves, Lídia Martins, Carla Bettencourt, Ana Jordan, Peter Vital, Nádia Pereira, Joana Pinto, Fátima Matos, Paulo Silva, Maria João Louro, Henriqueta |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Rolo, Dora Assunção, Ricardo Ventura, Célia Alvito, Paula Gonçalves, Lídia Martins, Carla Bettencourt, Ana Jordan, Peter Vital, Nádia Pereira, Joana Pinto, Fátima Matos, Paulo Silva, Maria João Louro, Henriqueta |
dc.subject.por.fl_str_mv |
titanium dioxide nanoparticles human exposure ingested TIO2-NPs AOP nanosafety colorectal cancer adverse outcomes |
topic |
titanium dioxide nanoparticles human exposure ingested TIO2-NPs AOP nanosafety colorectal cancer adverse outcomes |
description |
Titanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-21 2022-09-21T00:00:00Z 2023-09-11T16:38:36Z 2023-02-27T14:52:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/59208 |
url |
http://hdl.handle.net/10451/59208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rolo D, Assunção R, Ventura C, Alvito P, Gonçalves L, Martins C, et al. Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials [Internet]. 2022 Sep 21;12(19):3275. Available from: http://dx.doi.org/10.3390/nano12193275 cv-prod-3147551 10.3390/nano12193275 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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