Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study

Detalhes bibliográficos
Autor(a) principal: Monteiro, Marta
Data de Publicação: 2022
Outros Autores: Prata, Sara, Cardoso, Luís, Pereira da Fonseca, Isabel, Leal, Rodolfo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.5/27324
Resumo: Research Areas: Parasitology ; Tropical Medicine
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spelling Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based studyAntiproteinuric treatmentCanine leishmaniosisDogImmunosuppressantsQuestionnaire-based studyResearch Areas: Parasitology ; Tropical MedicineABSTRACT Background: Proteinuria is a common fnding in dogs with leishmaniosis. Although antileishmanial therapeutic protocols are widely implemented, little information is available on which treatments are most adequate for identifying proteinuria in patients with canine leishmaniosis (CanL), especially regarding the use of immunosuppressants. The aim of this study was to explore the current paradigm regarding the antiproteinuric approach adopted by veterinary practitioners in Portugal to treat dogs with CanL. Methods: A questionnaire-based study was developed using Google Forms®. The questionnaire presented a number of diferent hypothetical scenarios of CanL, and the topics surveyed included the general features of the respondents and the protocols preferred by these respondents to manage proteinuria in the presented scenarios, including choice of therapeutic drugs, appropriate diet and use of immunosuppressants, in dogs with immune-mediated glomerulonephritis. The questionnaire was internally prevalidated and difused online over a 2-month period through Portuguese veterinary social networking groups, and data were collected for descriptive analysis. Results: A total of 86 veterinary practitioners responded to the survey. When exposed to theoretical scenarios of proteinuria in dogs with CanL at stages IIb, III and IV (LeishVet guidelines), 16.3%, 62.8% and 93.8% of the respondents, respectively, answered that they would treat it. The dog was started on a renal diet as therapy by 28.6%, 83.3% and 97.4% of respondents, respectively. Angiotensin-converting enzyme inhibitors (ACEI) were prescribed by 100%, 85.2% and 78.9% of respondents as frst-choice drugs for CanL at stages IIb, III and IV, respectively, with ACEI used in monotherapy by 64.3%, 40.7% and 46.1%. In comparison, protocols using ACEI in combination with other compounds were chosen by 7.1%, 33.3% and 39.5% of respondents, and combination therapy which did not include ACEI was the choice of 0.0%, 12.9% and 14.5%. Regarding immunosuppressants, 44.2% of the respondents answered they would prescribe them, with 97.4% electing for prednisolone and 5.3% choosing mycophenolate mofetil. Conclusions: Among the veterinary practitioners who responded, proteinuria treatment was considered since stage IIb CanL, although implementation of a therapeutic approach was more evident in advanced CanL stages. ACEI were the frst-choice drugs, particularly for the treatment of stage IIb CanL; in advanced stages, a combination of antiproteinuric drugs was more often used. Immunosuppressant use was controversial, although when applied, prednisolone was the preferred choice. These fndings reinforce the small body of evidence that supports the use of such drugs and the need to further explore their role in CanL.BMCRepositório da Universidade de LisboaMonteiro, MartaPrata, SaraCardoso, LuísPereira da Fonseca, IsabelLeal, Rodolfo2023-02-22T11:29:35Z2022-04-112022-04-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.5/27324engMonteiro M, Prata S, Cardoso L, Fonseca IP, Leal RO. 2022. Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study. Parasites & Vectors, 15(1):125. DOI: https://doi.org/10.1186/s13071-022-05222-w1756-3305DOI10.1186/s13071-022-05222-winfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-06T14:56:41Zoai:www.repository.utl.pt:10400.5/27324Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:10:48.925882Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
title Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
spellingShingle Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
Monteiro, Marta
Antiproteinuric treatment
Canine leishmaniosis
Dog
Immunosuppressants
Questionnaire-based study
title_short Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
title_full Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
title_fullStr Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
title_full_unstemmed Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
title_sort Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study
author Monteiro, Marta
author_facet Monteiro, Marta
Prata, Sara
Cardoso, Luís
Pereira da Fonseca, Isabel
Leal, Rodolfo
author_role author
author2 Prata, Sara
Cardoso, Luís
Pereira da Fonseca, Isabel
Leal, Rodolfo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Monteiro, Marta
Prata, Sara
Cardoso, Luís
Pereira da Fonseca, Isabel
Leal, Rodolfo
dc.subject.por.fl_str_mv Antiproteinuric treatment
Canine leishmaniosis
Dog
Immunosuppressants
Questionnaire-based study
topic Antiproteinuric treatment
Canine leishmaniosis
Dog
Immunosuppressants
Questionnaire-based study
description Research Areas: Parasitology ; Tropical Medicine
publishDate 2022
dc.date.none.fl_str_mv 2022-04-11
2022-04-11T00:00:00Z
2023-02-22T11:29:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.5/27324
url http://hdl.handle.net/10400.5/27324
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Monteiro M, Prata S, Cardoso L, Fonseca IP, Leal RO. 2022. Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study. Parasites & Vectors, 15(1):125. DOI: https://doi.org/10.1186/s13071-022-05222-w
1756-3305
DOI10.1186/s13071-022-05222-w
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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