Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)

Detalhes bibliográficos
Autor(a) principal: Esmail, Asiyah
Data de Publicação: 2021
Outros Autores: Pereira, João R., Sevrin, Chantal, Grandfils, Christian, Menda, Ugur Deneb, Fortunato, Elvira, Oliva, Abel, Freitas, Filomena
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/132050
Resumo: LA/P/0140/2020 iNOVA4Health/MULTI/04462/2018
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spelling Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)Emulsion templatingP(3HB)P(3HBco- 3HV)Poly(3-hydroxybutyrate)Poly(3-hydroxybutyrate-co-3-hydroxyvaleratePorous scaffoldSalt leachingLA/P/0140/2020 iNOVA4Health/MULTI/04462/2018Poly(hydroxyalkanoates) (PHAs) with different material properties, namely, the homopolymer poly(3-hydroxybutyrate), P(3HB), and the copolymer poly(3-hydroxybutyrate-co-3- hydroxyvalerate, P(3HB-co-3HV), with a 3HV of 25 wt.%, were used for the preparation of porous biopolymeric scaffolds. Solvent casting with particulate leaching (SCPL) and emulsion templating were evaluated to process these biopolymers in porous scaffolds. SCPL scaffolds were highly hydrophilic (>170% swelling in water) but fragile, probably due to the increase of the polymer’s polydispersity index and its high porosity (>50%). In contrast, the emulsion templating technique resulted in scaffolds with a good compromise between porosity (27–49% porosity) and hydrophilicity (>30% water swelling) and without impairing their mechanical properties (3.18–3.35 MPa tensile strength and 0.07–0.11 MPa Young’s Modulus). These specifications are in the same range compared to other polymer-based scaffolds developed for tissue engineering. P(3HB-co-3HV) displayed the best overall properties, namely, lower crystallinity (11.3%) and higher flexibility (14.8% elongation at break. Our findings highlight the potency of our natural biopolyesters for the future development of novel porous scaffolds in tissue engineering, thanks also to their safety and biodegradability.DQ - Departamento de QuímicaUCIBIO - Applied Molecular Biosciences UnitInstituto de Tecnologia Química e Biológica António Xavier (ITQB)CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)DCM - Departamento de Ciência dos MateriaisProgramme in Translational Medicine (iNOVA4Health)RUNEsmail, AsiyahPereira, João R.Sevrin, ChantalGrandfils, ChristianMenda, Ugur DenebFortunato, ElviraOliva, AbelFreitas, Filomena2022-02-02T05:49:52Z2021-09-082021-09-08T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/132050eng2075-1729PURE: 34359620https://doi.org/10.3390/life11090935info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:10:42Zoai:run.unl.pt:10362/132050Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:47:19.593705Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
title Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
spellingShingle Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Esmail, Asiyah
Emulsion templating
P(3HB)
P(3HBco- 3HV)
Poly(3-hydroxybutyrate)
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate
Porous scaffold
Salt leaching
title_short Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
title_full Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
title_fullStr Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
title_full_unstemmed Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
title_sort Preparation and characterization of porous scaffolds based on poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
author Esmail, Asiyah
author_facet Esmail, Asiyah
Pereira, João R.
Sevrin, Chantal
Grandfils, Christian
Menda, Ugur Deneb
Fortunato, Elvira
Oliva, Abel
Freitas, Filomena
author_role author
author2 Pereira, João R.
Sevrin, Chantal
Grandfils, Christian
Menda, Ugur Deneb
Fortunato, Elvira
Oliva, Abel
Freitas, Filomena
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
UCIBIO - Applied Molecular Biosciences Unit
Instituto de Tecnologia Química e Biológica António Xavier (ITQB)
CENIMAT-i3N - Centro de Investigação de Materiais (Lab. Associado I3N)
DCM - Departamento de Ciência dos Materiais
Programme in Translational Medicine (iNOVA4Health)
RUN
dc.contributor.author.fl_str_mv Esmail, Asiyah
Pereira, João R.
Sevrin, Chantal
Grandfils, Christian
Menda, Ugur Deneb
Fortunato, Elvira
Oliva, Abel
Freitas, Filomena
dc.subject.por.fl_str_mv Emulsion templating
P(3HB)
P(3HBco- 3HV)
Poly(3-hydroxybutyrate)
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate
Porous scaffold
Salt leaching
topic Emulsion templating
P(3HB)
P(3HBco- 3HV)
Poly(3-hydroxybutyrate)
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate
Porous scaffold
Salt leaching
description LA/P/0140/2020 iNOVA4Health/MULTI/04462/2018
publishDate 2021
dc.date.none.fl_str_mv 2021-09-08
2021-09-08T00:00:00Z
2022-02-02T05:49:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/132050
url http://hdl.handle.net/10362/132050
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2075-1729
PURE: 34359620
https://doi.org/10.3390/life11090935
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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