Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/95089 https://doi.org/10.1089/ars.2020.8075 |
Resumo: | Significance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. On the contrary, absent of detrimental side effects but growing merits, regular physical exercise (PE) has been considered a prone pleiotropic nonpharmacological alternative able to modulate brain structure and function, thereby stimulating a healthier and "fitness" neurological phenotype. Future Directions: This review summarizes the state of the art of some peripheral and central-related mechanisms that underlie the impact of PE on brain plasticity as well as its relevance for the prevention and/or treatment of NDDs. Nevertheless, further studies are needed to better clarify the molecular signaling pathways associated with muscle contractions-related myokines release and its plausible positive effects in the brain. In addition, particular focus of research should address the role of PE in the modulation of mitochondrial metabolism and oxidative stress in the context of NDDs. |
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Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative DiseasesBDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscleSignificance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. On the contrary, absent of detrimental side effects but growing merits, regular physical exercise (PE) has been considered a prone pleiotropic nonpharmacological alternative able to modulate brain structure and function, thereby stimulating a healthier and "fitness" neurological phenotype. Future Directions: This review summarizes the state of the art of some peripheral and central-related mechanisms that underlie the impact of PE on brain plasticity as well as its relevance for the prevention and/or treatment of NDDs. Nevertheless, further studies are needed to better clarify the molecular signaling pathways associated with muscle contractions-related myokines release and its plausible positive effects in the brain. In addition, particular focus of research should address the role of PE in the modulation of mitochondrial metabolism and oxidative stress in the context of NDDs.2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/95089http://hdl.handle.net/10316/95089https://doi.org/10.1089/ars.2020.8075eng1523-08641557-7716https://www.liebertpub.com/doi/10.1089/ars.2020.8075?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed&Marques-Aleixo, InêsBeleza, JorgeSampaio, ArnaldinaStevanović, JelenaCoxito, PedroGonçalves, InêsAscensão, AntónioMagalhães, Joséinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2021-09-24T11:21:07Zoai:estudogeral.uc.pt:10316/95089Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:13:40.362463Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
title |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
spellingShingle |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases Marques-Aleixo, Inês BDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscle |
title_short |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
title_full |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
title_fullStr |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
title_full_unstemmed |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
title_sort |
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative Diseases |
author |
Marques-Aleixo, Inês |
author_facet |
Marques-Aleixo, Inês Beleza, Jorge Sampaio, Arnaldina Stevanović, Jelena Coxito, Pedro Gonçalves, Inês Ascensão, António Magalhães, José |
author_role |
author |
author2 |
Beleza, Jorge Sampaio, Arnaldina Stevanović, Jelena Coxito, Pedro Gonçalves, Inês Ascensão, António Magalhães, José |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Marques-Aleixo, Inês Beleza, Jorge Sampaio, Arnaldina Stevanović, Jelena Coxito, Pedro Gonçalves, Inês Ascensão, António Magalhães, José |
dc.subject.por.fl_str_mv |
BDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscle |
topic |
BDNF; brain; mitochondria; myokines; oxidative stress; skeletal muscle |
description |
Significance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to increase the underlying molecular mechanisms involved in NDD pathophysiologies, pharmacological therapies have been presenting merely narrow benefits. On the contrary, absent of detrimental side effects but growing merits, regular physical exercise (PE) has been considered a prone pleiotropic nonpharmacological alternative able to modulate brain structure and function, thereby stimulating a healthier and "fitness" neurological phenotype. Future Directions: This review summarizes the state of the art of some peripheral and central-related mechanisms that underlie the impact of PE on brain plasticity as well as its relevance for the prevention and/or treatment of NDDs. Nevertheless, further studies are needed to better clarify the molecular signaling pathways associated with muscle contractions-related myokines release and its plausible positive effects in the brain. In addition, particular focus of research should address the role of PE in the modulation of mitochondrial metabolism and oxidative stress in the context of NDDs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/95089 http://hdl.handle.net/10316/95089 https://doi.org/10.1089/ars.2020.8075 |
url |
http://hdl.handle.net/10316/95089 https://doi.org/10.1089/ars.2020.8075 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1523-0864 1557-7716 https://www.liebertpub.com/doi/10.1089/ars.2020.8075?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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