Differential impact of chronic stress along the hippocampal dorsal–ventral axis

Detalhes bibliográficos
Autor(a) principal: Pinto, Vítor
Data de Publicação: 2015
Outros Autores: Costa, João Carlos Cardoso, Morgado, Pedro, Mota, Cristina de Fátima Sousa da, Miranda, A., Bravo, Ana Francisca Rodrigues Vaz, Oliveira, Tiago Gil, Cerqueira, João, Sousa, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/29658
Resumo: First published online 06 February 2014
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spelling Differential impact of chronic stress along the hippocampal dorsal–ventral axisChronic stressHippocampal axisLTPLTDMorphologyScience & TechnologyFirst published online 06 February 2014Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chronic unpredictable stress (CUS) paradigm on the dorsal-ventral axis of the hippocampus. The morphological analysis demonstrated that CUS had opposite outcomes in the structure of the dorsal (DH) and ventral hippocampus (VH): whereas in the DH, stress triggered a volumetric reduction as a result of atrophy of CA3 and CA1 apical dendrites, in the VH there was an increase in hippocampal volume concurrent with the increase of CA3 apical dendrites. In parallel, electrophysiological data revealed that stress led to a decrease in VH LTD. In summary, the present work showed that stress impacts differently on the structure and function of the DH and VH which contributes to better understand the overall spectrum of the central effects of stress.Pinto V and Mota C were supported by Fundacao para a Ciencia e Tecnologia (FCT) grants (SFRH/BPD/69132/2010; SFRH/BD/81881/2011, respectively). This work was supported by an FCT grant (PTDC/SAU-NSC/120590/2010). The authors declare no competing financial interests.Springer VerlagUniversidade do MinhoPinto, VítorCosta, João Carlos CardosoMorgado, PedroMota, Cristina de Fátima Sousa daMiranda, A.Bravo, Ana Francisca Rodrigues VazOliveira, Tiago GilCerqueira, JoãoSousa, Nuno20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/29658engPinto, V., Costa, J. C., Morgado, P., Mota, C., Miranda, A., Bravo, F. V., . . . Sousa, N. (2015). Differential impact of chronic stress along the hippocampal dorsal-ventral axis. Brain Structure & Function, 220(2), 1205-1212. doi: 10.1007/s00429-014-0713-01863-265310.1007/s00429-014-0713-024500370http://link.springer.com/article/10.1007/s00429-014-0713-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:24:29Zoai:repositorium.sdum.uminho.pt:1822/29658Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:18:30.576104Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Differential impact of chronic stress along the hippocampal dorsal–ventral axis
title Differential impact of chronic stress along the hippocampal dorsal–ventral axis
spellingShingle Differential impact of chronic stress along the hippocampal dorsal–ventral axis
Pinto, Vítor
Chronic stress
Hippocampal axis
LTP
LTD
Morphology
Science & Technology
title_short Differential impact of chronic stress along the hippocampal dorsal–ventral axis
title_full Differential impact of chronic stress along the hippocampal dorsal–ventral axis
title_fullStr Differential impact of chronic stress along the hippocampal dorsal–ventral axis
title_full_unstemmed Differential impact of chronic stress along the hippocampal dorsal–ventral axis
title_sort Differential impact of chronic stress along the hippocampal dorsal–ventral axis
author Pinto, Vítor
author_facet Pinto, Vítor
Costa, João Carlos Cardoso
Morgado, Pedro
Mota, Cristina de Fátima Sousa da
Miranda, A.
Bravo, Ana Francisca Rodrigues Vaz
Oliveira, Tiago Gil
Cerqueira, João
Sousa, Nuno
author_role author
author2 Costa, João Carlos Cardoso
Morgado, Pedro
Mota, Cristina de Fátima Sousa da
Miranda, A.
Bravo, Ana Francisca Rodrigues Vaz
Oliveira, Tiago Gil
Cerqueira, João
Sousa, Nuno
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pinto, Vítor
Costa, João Carlos Cardoso
Morgado, Pedro
Mota, Cristina de Fátima Sousa da
Miranda, A.
Bravo, Ana Francisca Rodrigues Vaz
Oliveira, Tiago Gil
Cerqueira, João
Sousa, Nuno
dc.subject.por.fl_str_mv Chronic stress
Hippocampal axis
LTP
LTD
Morphology
Science & Technology
topic Chronic stress
Hippocampal axis
LTP
LTD
Morphology
Science & Technology
description First published online 06 February 2014
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/29658
url http://hdl.handle.net/1822/29658
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pinto, V., Costa, J. C., Morgado, P., Mota, C., Miranda, A., Bravo, F. V., . . . Sousa, N. (2015). Differential impact of chronic stress along the hippocampal dorsal-ventral axis. Brain Structure & Function, 220(2), 1205-1212. doi: 10.1007/s00429-014-0713-0
1863-2653
10.1007/s00429-014-0713-0
24500370
http://link.springer.com/article/10.1007/s00429-014-0713-0
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132640306003968

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