Nanotechnology-Ocular Devices for Glaucoma Treatment: A Literature Review

• Autor(a) principal: Cardigos, J
• Data de Publicação: 2019
• Outros Autores: Ferreira, Q, Crisóstomo, S, Coelho, N, Cunha, JP, Abegão Pinto, L, Ferreira, J
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10400.17/3858
• topic: HSAC OFT; Antihypertensive Agents / administration & dosage; Drug Delivery Systems; Glaucoma / drug therapy; Humans; Nanoparticles / administration & dosage; Nanotechnology / instrumentation

Nanotechnology enabled the development of materials and devices with great utility in different fields of medicine. By using engineered-based nano-devices and structures, human biological systems may be controlled and repaired at a molecular scale, ultimately leading to a biological benefit. In particular, in the field of glaucoma treatment, nanotechnology may, for example, enhance drug residence time on the ocular surface and ocular bioavailability, as well as improve surgical success by both optimizing postoperative scarring and providing a wider safety window. Further studies are still needed to entirely explain the pharmacodynamics of nanotechnology-based therapeutic approaches and prove their biological consequences in human eyes. This review aims to summarize the literature concerning the advances in nanotechnology, specifically regarding ocular devices applied to the treatment of glaucoma.