Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca

Detalhes bibliográficos
Autor(a) principal: Feijão, Eduardo
Data de Publicação: 2022
Outros Autores: Carvalho, Ricardo Cruz de, Duarte, Irina A., Matos, Ana Rita, Cabrita, Maria Teresa, Utkin, Andrei B., Caçador, Isabel, Marques, João Carlos, Novais, Sara C., Lemos, Marco F.L., Reis-Santos, Patrick, Fonseca, Vanessa, Duarte, Bernardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8729
Resumo: The authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research at MARE (UIDB/04292/2020 and UIDP/04292/2020), ARNET-Aquatic Research Infrastructure Network Associated Laboratory (LA/P/0069/2020), BioISI (UID/MULTI/04046/2019) and via project grant PTDC/CTA-AMB/30056/2017 (OPTOX). Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. BD and VF were supported by researcher contracts (CEEC-IND/00511/2017 and 2021.00244.CEECIND). MC and SN is supported by a DL-57 investigation contract.
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spelling Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactucaAntidepressantsMacroalgaeOxidative stressPharmaceuticalsPhotobiologyThe authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research at MARE (UIDB/04292/2020 and UIDP/04292/2020), ARNET-Aquatic Research Infrastructure Network Associated Laboratory (LA/P/0069/2020), BioISI (UID/MULTI/04046/2019) and via project grant PTDC/CTA-AMB/30056/2017 (OPTOX). Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. BD and VF were supported by researcher contracts (CEEC-IND/00511/2017 and 2021.00244.CEECIND). MC and SN is supported by a DL-57 investigation contract.Emerging pollutants impose a high degree of stress on marine ecosystems, compromising valuable resources, the planet and human health. Pharmaceutical residues often reachmarine ecosystems, and their input is directly related to human activities. Fluoxetine is an antidepressant, and one of the most prescribed selective serotonin reuptake inhibitors globally and has been detected in aquatic ecosystems in concentrations up to 40 μg L−1. The present study aims to evaluate the impact of fluoxetine ecotoxicity on the photochemistry, energy metabolism and enzyme activity of Ulva lactuca exposed to environmentally relevant concentrations (0.3, 0.6, 20, 40, and 80 μg L−1). Exogenous fluoxetine exposure induced negative impacts on U. lactuca photochemistry, namely on photosystem II antennae grouping and energy fluxes. These impacts included increased oxidative stress and elevated enzymatic activity of ascorbate peroxidase and glutathione reductase. Lipid content increased and the altered levels of key fatty acids such as hexadecadienoic (C16:2) and linoleic (C18:2) acids revealed strong correlations with fluoxetine concentrations tested. Multivariate analyses reinforced the oxidative stress and chlorophyll a fluorescence-derived traits as efficient biomarkers for future toxicology studies.FrontiersIC-OnlineFeijão, EduardoCarvalho, Ricardo Cruz deDuarte, Irina A.Matos, Ana RitaCabrita, Maria TeresaUtkin, Andrei B.Caçador, IsabelMarques, João CarlosNovais, Sara C.Lemos, Marco F.L.Reis-Santos, PatrickFonseca, VanessaDuarte, Bernardo2023-08-24T11:18:06Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8729engFeijão E, Cruz de Carvalho R, Duarte IA, Matos AR, Cabrita MT, Utkin AB, Caçador I, Marques JC, Novais SC, Lemos MFL, Reis-Santos P, Fonseca VF and Duarte B (2022), Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca. Front. Environ. Sci. 10:963537. doi: 10.3389/fenvs.2022.9635372296-665X10.3389/fenvs.2022.963537info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:58:03Zoai:iconline.ipleiria.pt:10400.8/8729Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:23.528581Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
title Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
spellingShingle Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
Feijão, Eduardo
Antidepressants
Macroalgae
Oxidative stress
Pharmaceuticals
Photobiology
title_short Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
title_full Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
title_fullStr Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
title_full_unstemmed Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
title_sort Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca
author Feijão, Eduardo
author_facet Feijão, Eduardo
Carvalho, Ricardo Cruz de
Duarte, Irina A.
Matos, Ana Rita
Cabrita, Maria Teresa
Utkin, Andrei B.
Caçador, Isabel
Marques, João Carlos
Novais, Sara C.
Lemos, Marco F.L.
Reis-Santos, Patrick
Fonseca, Vanessa
Duarte, Bernardo
author_role author
author2 Carvalho, Ricardo Cruz de
Duarte, Irina A.
Matos, Ana Rita
Cabrita, Maria Teresa
Utkin, Andrei B.
Caçador, Isabel
Marques, João Carlos
Novais, Sara C.
Lemos, Marco F.L.
Reis-Santos, Patrick
Fonseca, Vanessa
Duarte, Bernardo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Feijão, Eduardo
Carvalho, Ricardo Cruz de
Duarte, Irina A.
Matos, Ana Rita
Cabrita, Maria Teresa
Utkin, Andrei B.
Caçador, Isabel
Marques, João Carlos
Novais, Sara C.
Lemos, Marco F.L.
Reis-Santos, Patrick
Fonseca, Vanessa
Duarte, Bernardo
dc.subject.por.fl_str_mv Antidepressants
Macroalgae
Oxidative stress
Pharmaceuticals
Photobiology
topic Antidepressants
Macroalgae
Oxidative stress
Pharmaceuticals
Photobiology
description The authors would like to thank Fundação para a Ciência e a Tecnologia (FCT) for funding the research at MARE (UIDB/04292/2020 and UIDP/04292/2020), ARNET-Aquatic Research Infrastructure Network Associated Laboratory (LA/P/0069/2020), BioISI (UID/MULTI/04046/2019) and via project grant PTDC/CTA-AMB/30056/2017 (OPTOX). Work was also funded by the Integrated Programme of SR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. BD and VF were supported by researcher contracts (CEEC-IND/00511/2017 and 2021.00244.CEECIND). MC and SN is supported by a DL-57 investigation contract.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01T00:00:00Z
2023-08-24T11:18:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8729
url http://hdl.handle.net/10400.8/8729
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Feijão E, Cruz de Carvalho R, Duarte IA, Matos AR, Cabrita MT, Utkin AB, Caçador I, Marques JC, Novais SC, Lemos MFL, Reis-Santos P, Fonseca VF and Duarte B (2022), Fluoxetine induces photochemistry-derived oxidative stress on Ulva lactuca. Front. Environ. Sci. 10:963537. doi: 10.3389/fenvs.2022.963537
2296-665X
10.3389/fenvs.2022.963537
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers
publisher.none.fl_str_mv Frontiers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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