From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds

Detalhes bibliográficos
Autor(a) principal: Alves, Celso
Data de Publicação: 2018
Outros Autores: Silva, Joana, Pinteus, Susete, Gaspar, Helena, Alpoim, Maria C., Botana, Luís M., Pedrosa, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/4972
Resumo: Authors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Projects UID/MAR/04292/2013 and UID/Multi/04046/2013 granted to MARE – Marine and Environmental Sciences Centre and BioISI - BioSystems and Integrative Sciences Institute, respectively, through Red2Discovery Project (PTDC/MAR-BIO/6149/2014), cofinanced by COMPETE (POCI-01-0145-FEDER-016791), and through Oncologia de Precisão: Terapias e Tecnologias Inovadoras project (POINT4PAC) (SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER-016405). The authors also wish to acknowledge the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. CA, SP, and JS are financial supported by a grant from FCT (SFRH/BD/97764/2013, SFRH/BD/96203/2013, and (SFRH/BD/103255/2014, respectively).
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spelling From marine origin to therapeutics: the antitumor potential of marine algae-derived compoundsCancerMarine natural productsSeaweedsIntracellular signaling pathwaysBiodiversity,Marine chemical ecologySphaerococcus coronopifoliusAuthors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Projects UID/MAR/04292/2013 and UID/Multi/04046/2013 granted to MARE – Marine and Environmental Sciences Centre and BioISI - BioSystems and Integrative Sciences Institute, respectively, through Red2Discovery Project (PTDC/MAR-BIO/6149/2014), cofinanced by COMPETE (POCI-01-0145-FEDER-016791), and through Oncologia de Precisão: Terapias e Tecnologias Inovadoras project (POINT4PAC) (SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER-016405). The authors also wish to acknowledge the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. CA, SP, and JS are financial supported by a grant from FCT (SFRH/BD/97764/2013, SFRH/BD/96203/2013, and (SFRH/BD/103255/2014, respectively).Marine environment has demonstrated to be an interesting source of compounds with uncommon and unique chemical features on which themolecularmodeling and chemical synthesis of new drugs can be based with greater efficacy and specificity for the therapeutics. Cancer is a growing public health threat, and despite the advances in biomedical research and technology, there is an urgent need for the development of new anticancer drugs. In this field, it is estimated that more than 60% of commercially available anticancer drugs are natural biomimetic inspired. Among the marine organisms, algae have revealed to be one of the major sources of new compounds of marine origin, including those exhibiting antitumor and cytotoxic potential. These compounds demonstrated ability to mediate specific inhibitory activities on a number of key cellular processes, including apoptosis pathways, angiogenesis, migration and invasion, in both in vitro and in vivo models, revealing their potential to be used as anticancer drugs. This review will focus on the bioactive molecules from algae with antitumor potential, from their origin to their potential uses, with special emphasis to the alga Sphaerococcus coronopifolius as a producer of cytotoxic compounds.IC-OnlineAlves, CelsoSilva, JoanaPinteus, SuseteGaspar, HelenaAlpoim, Maria C.Botana, Luís M.Pedrosa, Rui2020-06-30T15:23:18Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/4972engAlves C, Silva J, Pinteus S, Gaspar H, Alpoim MC, Botana LM and Pedrosa R (2018) From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds. Front. Pharmacol. 9:777. doi: 10.3389/fphar.2018.007771663-981210.3389/fphar.2018.00777info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:50:21Zoai:iconline.ipleiria.pt:10400.8/4972Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:48:40.635314Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
title From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
spellingShingle From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
Alves, Celso
Cancer
Marine natural products
Seaweeds
Intracellular signaling pathways
Biodiversity,
Marine chemical ecology
Sphaerococcus coronopifolius
title_short From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
title_full From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
title_fullStr From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
title_full_unstemmed From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
title_sort From marine origin to therapeutics: the antitumor potential of marine algae-derived compounds
author Alves, Celso
author_facet Alves, Celso
Silva, Joana
Pinteus, Susete
Gaspar, Helena
Alpoim, Maria C.
Botana, Luís M.
Pedrosa, Rui
author_role author
author2 Silva, Joana
Pinteus, Susete
Gaspar, Helena
Alpoim, Maria C.
Botana, Luís M.
Pedrosa, Rui
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Alves, Celso
Silva, Joana
Pinteus, Susete
Gaspar, Helena
Alpoim, Maria C.
Botana, Luís M.
Pedrosa, Rui
dc.subject.por.fl_str_mv Cancer
Marine natural products
Seaweeds
Intracellular signaling pathways
Biodiversity,
Marine chemical ecology
Sphaerococcus coronopifolius
topic Cancer
Marine natural products
Seaweeds
Intracellular signaling pathways
Biodiversity,
Marine chemical ecology
Sphaerococcus coronopifolius
description Authors would like to acknowledge the financial support of the Portuguese Foundation for Science and Technology (FCT) through Strategic Projects UID/MAR/04292/2013 and UID/Multi/04046/2013 granted to MARE – Marine and Environmental Sciences Centre and BioISI - BioSystems and Integrative Sciences Institute, respectively, through Red2Discovery Project (PTDC/MAR-BIO/6149/2014), cofinanced by COMPETE (POCI-01-0145-FEDER-016791), and through Oncologia de Precisão: Terapias e Tecnologias Inovadoras project (POINT4PAC) (SAICTPAC/0019/2015 - LISBOA-01-0145-FEDER-016405). The authors also wish to acknowledge the Integrated Programme of SR&TD Smart Valorization of Endogenous Marine Biological Resources Under a Changing Climate (reference Centro-01-0145-FEDER000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fund. CA, SP, and JS are financial supported by a grant from FCT (SFRH/BD/97764/2013, SFRH/BD/96203/2013, and (SFRH/BD/103255/2014, respectively).
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2020-06-30T15:23:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/4972
url http://hdl.handle.net/10400.8/4972
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Alves C, Silva J, Pinteus S, Gaspar H, Alpoim MC, Botana LM and Pedrosa R (2018) From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds. Front. Pharmacol. 9:777. doi: 10.3389/fphar.2018.00777
1663-9812
10.3389/fphar.2018.00777
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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