Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia

Detalhes bibliográficos
Autor(a) principal: Silva, F
Data de Publicação: 2011
Outros Autores: Morais, S, Sevivas, T, Veiga, R, Salvado, R, Taborda, A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/1416
Resumo: Neonatal alloimmune thrombocytopenia is a rare (1/1000-5000 births) life-threatening disorder, caused by fetomaternal incompatibility for a fetal human platelet alloantigen inherited from the father, with production of maternal alloantibodies against fetal platelets, leading to severe thrombocytopenia and potential bleeding. Intracranial haemorrhage is the most feared complication. This report presents the case of a term newborn infant, born from caesarean section after a normal pregnancy, presenting signs of skin bleeding with different ages. Obstetric history included a previous spontaneous abortion after amniocentesis. Severe thrombocytopenia (4×10(9)/l platelets) was found and brain ultrasound showed multiple intracranial haemorrhages. Human platelet antigen (HPA) phenotyping showed maternal negative HPA-1a and paternal positive HPA-1a platelets. Strongly positive anti-HPA-1a and weakly positive anti-human leukocyte antigen class I alloantibodies were found in the mother. Multiple platelet transfusions, intravenous immunoglobulin and corticosteroid were given but favourable response was accomplished only after a compatible platelet transfusion. Brain MRI showed multiple subacute and chronic haemorrhages.
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spelling Severe intracranial haemorrhage in neonatal alloimmune thrombocytopeniaTrombocitopénia Neonatal AloimuneRecém-NascidoHemorragia IntracranianaNeonatal alloimmune thrombocytopenia is a rare (1/1000-5000 births) life-threatening disorder, caused by fetomaternal incompatibility for a fetal human platelet alloantigen inherited from the father, with production of maternal alloantibodies against fetal platelets, leading to severe thrombocytopenia and potential bleeding. Intracranial haemorrhage is the most feared complication. This report presents the case of a term newborn infant, born from caesarean section after a normal pregnancy, presenting signs of skin bleeding with different ages. Obstetric history included a previous spontaneous abortion after amniocentesis. Severe thrombocytopenia (4×10(9)/l platelets) was found and brain ultrasound showed multiple intracranial haemorrhages. Human platelet antigen (HPA) phenotyping showed maternal negative HPA-1a and paternal positive HPA-1a platelets. Strongly positive anti-HPA-1a and weakly positive anti-human leukocyte antigen class I alloantibodies were found in the mother. Multiple platelet transfusions, intravenous immunoglobulin and corticosteroid were given but favourable response was accomplished only after a compatible platelet transfusion. Brain MRI showed multiple subacute and chronic haemorrhages.RIHUCSilva, FMorais, SSevivas, TVeiga, RSalvado, RTaborda, A2012-06-20T11:28:00Z20112011-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/1416engBMJ Case Rep. 2011 Sep 4;2011.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:22:41Zoai:rihuc.huc.min-saude.pt:10400.4/1416Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:55.708132Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
title Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
spellingShingle Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
Silva, F
Trombocitopénia Neonatal Aloimune
Recém-Nascido
Hemorragia Intracraniana
title_short Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
title_full Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
title_fullStr Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
title_full_unstemmed Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
title_sort Severe intracranial haemorrhage in neonatal alloimmune thrombocytopenia
author Silva, F
author_facet Silva, F
Morais, S
Sevivas, T
Veiga, R
Salvado, R
Taborda, A
author_role author
author2 Morais, S
Sevivas, T
Veiga, R
Salvado, R
Taborda, A
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Silva, F
Morais, S
Sevivas, T
Veiga, R
Salvado, R
Taborda, A
dc.subject.por.fl_str_mv Trombocitopénia Neonatal Aloimune
Recém-Nascido
Hemorragia Intracraniana
topic Trombocitopénia Neonatal Aloimune
Recém-Nascido
Hemorragia Intracraniana
description Neonatal alloimmune thrombocytopenia is a rare (1/1000-5000 births) life-threatening disorder, caused by fetomaternal incompatibility for a fetal human platelet alloantigen inherited from the father, with production of maternal alloantibodies against fetal platelets, leading to severe thrombocytopenia and potential bleeding. Intracranial haemorrhage is the most feared complication. This report presents the case of a term newborn infant, born from caesarean section after a normal pregnancy, presenting signs of skin bleeding with different ages. Obstetric history included a previous spontaneous abortion after amniocentesis. Severe thrombocytopenia (4×10(9)/l platelets) was found and brain ultrasound showed multiple intracranial haemorrhages. Human platelet antigen (HPA) phenotyping showed maternal negative HPA-1a and paternal positive HPA-1a platelets. Strongly positive anti-HPA-1a and weakly positive anti-human leukocyte antigen class I alloantibodies were found in the mother. Multiple platelet transfusions, intravenous immunoglobulin and corticosteroid were given but favourable response was accomplished only after a compatible platelet transfusion. Brain MRI showed multiple subacute and chronic haemorrhages.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-01-01T00:00:00Z
2012-06-20T11:28:00Z
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv BMJ Case Rep. 2011 Sep 4;2011.
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