Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8452 |
Resumo: | Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861572/ |
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Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysisInfluenzaVaccinationVaccine ImpactCost-effectivenessMathematical ModellingVacina AntigripalEuropeDeterminantes da Saúde e da DoençaFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861572/Introduction: Despite seasonal influenza vaccination programmes in most countries targeting individuals aged ≥ 65 (or ≥ 55) years and high risk-groups, significant disease burden remains. We explored the impact and cost-effectiveness of 27 vaccination programmes targeting the elderly and/or children in eight European settings (n = 205.8 million). Methods: We used an age-structured dynamic-transmission model to infer age- and (sub-)type-specific seasonal influenza virus infections calibrated to England, France, Ireland, Navarra, The Netherlands, Portugal, Scotland, and Spain between 2010/11 and 2017/18. The base-case vaccination scenario consisted of non-adjuvanted, non-high dose trivalent vaccines (TV) and no universal paediatric vaccination. We explored i) moving the elderly to "improved" (i.e., adjuvanted or high-dose) trivalent vaccines (iTV) or non-adjuvanted non-high-dose quadrivalent vaccines (QV); ii) adopting mass paediatric vaccination with TV or QV; and iii) combining the elderly and paediatric strategies. We estimated setting-specific costs and quality-adjusted life years (QALYs) gained from the healthcare perspective, and discounted QALYs at 3.0%. Results: In the elderly, the estimated numbers of infection per 100,000 population are reduced by a median of 261.5 (range across settings: 154.4, 475.7) when moving the elderly to iTV and by 150.8 (77.6, 262.3) when moving them to QV. Through indirect protection, adopting mass paediatric programmes with 25% uptake achieves similar reductions in the elderly of 233.6 using TV (range: 58.9, 425.6) or 266.5 using QV (65.7, 477.9), with substantial health gains from averted infections across ages. At €35,000/QALY gained, moving the elderly to iTV plus adopting mass paediatric QV programmes provides the highest mean net benefits and probabilities of being cost-effective in all settings and paediatric coverage levels. Conclusion: Given the direct and indirect protection, and depending on the vaccine prices, model results support a combination of having moved the elderly to an improved vaccine and adopting universal paediatric vaccination programmes across the European settings.Highlights: Seasonal influenza vaccine programmes usually target at-risk and older individuals; We used an age-structured dynamic-transmission model for eight European settings; Older people benefit from adjuvanted or high-dose trivalent or quadrivalent vaccines; Adopting mass paediatric influenza vaccination is also likely to be cost-effective; Results rest on vaccine costs, willingness to vaccinate and unknown long-term effects.I-MOVE+ (Integrated Monitoring of Vaccines in Europe) project, received a grant from the European Commission Horizon 2020 research and innovation programme (grant agreement No 634446).ElsevierRepositório Científico do Instituto Nacional de SaúdeSandmann, Frankvan Leeuwen, EdwinBernard-Stoecklin, SibylleCasado, ItziarCastilla, JesúsDomegan, LisaGherasim, AlinHooiveld, MariëtteKislaya, IrinaLarrauri, AmparoLevy-Bruhl, DanielMachado, AusendaMarques, DiogoMartínez-Baz, IvánMazagatos, ClaraMcMenamin, JimMeijer, AdamMurray, JosephineNunes, BaltazarO'Donnell, JoanReynolds, ArleneThorrington, DominicPebody, RichardBaguelin, Marc2023-01-25T11:21:52Z2022-02-232022-02-23T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8452engVaccine. 2022 Feb 23;40(9):1306-1315. doi: 10.1016/j.vaccine.2022.01.015. Epub 2022 Jan 31.0264-410X10.1016/j.vaccine.2022.01.015info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:24Zoai:repositorio.insa.pt:10400.18/8452Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:47.699034Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| title |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| spellingShingle |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis Sandmann, Frank Influenza Vaccination Vaccine Impact Cost-effectiveness Mathematical Modelling Vacina Antigripal Europe Determinantes da Saúde e da Doença |
| title_short |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| title_full |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| title_fullStr |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| title_full_unstemmed |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| title_sort |
Health and economic impact of seasonal influenza mass vaccination strategies in European settings: A mathematical modelling and cost-effectiveness analysis |
| author |
Sandmann, Frank |
| author_facet |
Sandmann, Frank van Leeuwen, Edwin Bernard-Stoecklin, Sibylle Casado, Itziar Castilla, Jesús Domegan, Lisa Gherasim, Alin Hooiveld, Mariëtte Kislaya, Irina Larrauri, Amparo Levy-Bruhl, Daniel Machado, Ausenda Marques, Diogo Martínez-Baz, Iván Mazagatos, Clara McMenamin, Jim Meijer, Adam Murray, Josephine Nunes, Baltazar O'Donnell, Joan Reynolds, Arlene Thorrington, Dominic Pebody, Richard Baguelin, Marc |
| author_role |
author |
| author2 |
van Leeuwen, Edwin Bernard-Stoecklin, Sibylle Casado, Itziar Castilla, Jesús Domegan, Lisa Gherasim, Alin Hooiveld, Mariëtte Kislaya, Irina Larrauri, Amparo Levy-Bruhl, Daniel Machado, Ausenda Marques, Diogo Martínez-Baz, Iván Mazagatos, Clara McMenamin, Jim Meijer, Adam Murray, Josephine Nunes, Baltazar O'Donnell, Joan Reynolds, Arlene Thorrington, Dominic Pebody, Richard Baguelin, Marc |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Sandmann, Frank van Leeuwen, Edwin Bernard-Stoecklin, Sibylle Casado, Itziar Castilla, Jesús Domegan, Lisa Gherasim, Alin Hooiveld, Mariëtte Kislaya, Irina Larrauri, Amparo Levy-Bruhl, Daniel Machado, Ausenda Marques, Diogo Martínez-Baz, Iván Mazagatos, Clara McMenamin, Jim Meijer, Adam Murray, Josephine Nunes, Baltazar O'Donnell, Joan Reynolds, Arlene Thorrington, Dominic Pebody, Richard Baguelin, Marc |
| dc.subject.por.fl_str_mv |
Influenza Vaccination Vaccine Impact Cost-effectiveness Mathematical Modelling Vacina Antigripal Europe Determinantes da Saúde e da Doença |
| topic |
Influenza Vaccination Vaccine Impact Cost-effectiveness Mathematical Modelling Vacina Antigripal Europe Determinantes da Saúde e da Doença |
| description |
Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8861572/ |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-02-23 2022-02-23T00:00:00Z 2023-01-25T11:21:52Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8452 |
| url |
http://hdl.handle.net/10400.18/8452 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Vaccine. 2022 Feb 23;40(9):1306-1315. doi: 10.1016/j.vaccine.2022.01.015. Epub 2022 Jan 31. 0264-410X 10.1016/j.vaccine.2022.01.015 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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