Primary visual cortical remapping in patients with inherited peripheral retinal degeneration
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108283 https://doi.org/10.1016/j.nicl.2016.12.013 |
Resumo: | Human studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to peripheral visual degeneration. We acquired functional and anatomical magnetic resonance data from thirteen patients with different levels of visual loss and twenty-two healthy participants to study primary (V1) visual cortical retinotopic remapping and cortical thickness. We identified systematic visual field remapping in the absence of structural changes in the primary visual cortex of RP patients. Remapping consisted in a retinotopic eccentricity shift of central retinal inputs to more peripheral locations in V1. Importantly, this was associated with changes in visual experience, as assessed by the extent of the visual loss, with more constricted visual fields resulting in larger remapping. This pattern of remapping is consistent with expansion or shifting of neuronal receptive fields into the cortical regions with reduced retinal input. These data provide evidence for functional changes in V1 that are dependent on the magnitude of peripheral visual loss in RP, which may be explained by rapid cortical adaptation mechanisms or long-term cortical reorganization. This study highlights the importance of analyzing the retinal determinants of brain functional and structural alterations for future visual restoration approaches. |
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Primary visual cortical remapping in patients with inherited peripheral retinal degenerationFunctional magnetic resonance imaging (fMRI)HumanRetinitis pigmentosaPlasticityReorganizationPrimary visual cortexRetinotopyAdultAgedBrain MappingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRetinitis PigmentosaVision, LowVisual CortexVisual FieldsVisual PerceptionYoung AdultHuman studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to peripheral visual degeneration. We acquired functional and anatomical magnetic resonance data from thirteen patients with different levels of visual loss and twenty-two healthy participants to study primary (V1) visual cortical retinotopic remapping and cortical thickness. We identified systematic visual field remapping in the absence of structural changes in the primary visual cortex of RP patients. Remapping consisted in a retinotopic eccentricity shift of central retinal inputs to more peripheral locations in V1. Importantly, this was associated with changes in visual experience, as assessed by the extent of the visual loss, with more constricted visual fields resulting in larger remapping. This pattern of remapping is consistent with expansion or shifting of neuronal receptive fields into the cortical regions with reduced retinal input. These data provide evidence for functional changes in V1 that are dependent on the magnitude of peripheral visual loss in RP, which may be explained by rapid cortical adaptation mechanisms or long-term cortical reorganization. This study highlights the importance of analyzing the retinal determinants of brain functional and structural alterations for future visual restoration approaches.Elsevier2017info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108283http://hdl.handle.net/10316/108283https://doi.org/10.1016/j.nicl.2016.12.013eng22131582Ferreira, SóniaPereira, Andreia CarvalhoQuendera, BrunoReis, AldinaSilva, Eduardo DuarteCastelo-Branco, Miguelinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-22T11:15:58Zoai:estudogeral.uc.pt:10316/108283Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:24:35.428306Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
title |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
spellingShingle |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration Ferreira, Sónia Functional magnetic resonance imaging (fMRI) Human Retinitis pigmentosa Plasticity Reorganization Primary visual cortex Retinotopy Adult Aged Brain Mapping Female Humans Magnetic Resonance Imaging Male Middle Aged Retinitis Pigmentosa Vision, Low Visual Cortex Visual Fields Visual Perception Young Adult |
title_short |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
title_full |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
title_fullStr |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
title_full_unstemmed |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
title_sort |
Primary visual cortical remapping in patients with inherited peripheral retinal degeneration |
author |
Ferreira, Sónia |
author_facet |
Ferreira, Sónia Pereira, Andreia Carvalho Quendera, Bruno Reis, Aldina Silva, Eduardo Duarte Castelo-Branco, Miguel |
author_role |
author |
author2 |
Pereira, Andreia Carvalho Quendera, Bruno Reis, Aldina Silva, Eduardo Duarte Castelo-Branco, Miguel |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, Sónia Pereira, Andreia Carvalho Quendera, Bruno Reis, Aldina Silva, Eduardo Duarte Castelo-Branco, Miguel |
dc.subject.por.fl_str_mv |
Functional magnetic resonance imaging (fMRI) Human Retinitis pigmentosa Plasticity Reorganization Primary visual cortex Retinotopy Adult Aged Brain Mapping Female Humans Magnetic Resonance Imaging Male Middle Aged Retinitis Pigmentosa Vision, Low Visual Cortex Visual Fields Visual Perception Young Adult |
topic |
Functional magnetic resonance imaging (fMRI) Human Retinitis pigmentosa Plasticity Reorganization Primary visual cortex Retinotopy Adult Aged Brain Mapping Female Humans Magnetic Resonance Imaging Male Middle Aged Retinitis Pigmentosa Vision, Low Visual Cortex Visual Fields Visual Perception Young Adult |
description |
Human studies addressing the long-term effects of peripheral retinal degeneration on visual cortical function and structure are scarce. Here we investigated this question in patients with Retinitis Pigmentosa (RP), a genetic condition leading to peripheral visual degeneration. We acquired functional and anatomical magnetic resonance data from thirteen patients with different levels of visual loss and twenty-two healthy participants to study primary (V1) visual cortical retinotopic remapping and cortical thickness. We identified systematic visual field remapping in the absence of structural changes in the primary visual cortex of RP patients. Remapping consisted in a retinotopic eccentricity shift of central retinal inputs to more peripheral locations in V1. Importantly, this was associated with changes in visual experience, as assessed by the extent of the visual loss, with more constricted visual fields resulting in larger remapping. This pattern of remapping is consistent with expansion or shifting of neuronal receptive fields into the cortical regions with reduced retinal input. These data provide evidence for functional changes in V1 that are dependent on the magnitude of peripheral visual loss in RP, which may be explained by rapid cortical adaptation mechanisms or long-term cortical reorganization. This study highlights the importance of analyzing the retinal determinants of brain functional and structural alterations for future visual restoration approaches. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108283 http://hdl.handle.net/10316/108283 https://doi.org/10.1016/j.nicl.2016.12.013 |
url |
http://hdl.handle.net/10316/108283 https://doi.org/10.1016/j.nicl.2016.12.013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
22131582 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134129934041088 |