Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family

Detalhes bibliográficos
Autor(a) principal: Belo, José A.
Data de Publicação: 2009
Outros Autores: Silva, Ana C., Borges, Ana, Filipe, Mário, Bento, Margaret, Gonçalves, Lisa, Vitorino, Marta, Salgueiro, Ana Marisa, Texeira, Vera, Tavares, Ana T., Marques, Sara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/12103
Resumo: One fundamental aspect of vertebrate embryonic development is the formation of the body plan. For this process, asymmetries have to be generated during early stages of development along the three main body axes: Anterior-Posterior, Dorso-Ventral and Left-Right. We have been studying the role of a novel class of molecules,the Cerberus/Dan gene family. These are dedicated secreted antagonists of three major signaling pathways: Nodal, BMP and Wnt. Our studies contribute to the current view that the fine tuning of signaling is controlled by a set of inhibitory molecules rather than by activators. In this context, the Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo.
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spelling Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like familyAnterior primitive endodermMouse forebrain developmentVisceral endodermNodal expressionXenopus embryosChick-embryoNeuralizing activityLateral-inhibitionSpemanns organizerSecreted proteinsOne fundamental aspect of vertebrate embryonic development is the formation of the body plan. For this process, asymmetries have to be generated during early stages of development along the three main body axes: Anterior-Posterior, Dorso-Ventral and Left-Right. We have been studying the role of a novel class of molecules,the Cerberus/Dan gene family. These are dedicated secreted antagonists of three major signaling pathways: Nodal, BMP and Wnt. Our studies contribute to the current view that the fine tuning of signaling is controlled by a set of inhibitory molecules rather than by activators. In this context, the Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo.C.R.U.P; F.C.T.; IGC/Fundação Calouste GulbenkianU B C PressSapientiaBelo, José A.Silva, Ana C.Borges, AnaFilipe, MárioBento, MargaretGonçalves, LisaVitorino, MartaSalgueiro, Ana MarisaTexeira, VeraTavares, Ana T.Marques, Sara2018-12-07T14:58:35Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/12103eng0214-628210.1387/ijdb.072297jbinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:24:02Zoai:sapientia.ualg.pt:10400.1/12103Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:03:30.419522Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
title Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
spellingShingle Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
Belo, José A.
Anterior primitive endoderm
Mouse forebrain development
Visceral endoderm
Nodal expression
Xenopus embryos
Chick-embryo
Neuralizing activity
Lateral-inhibition
Spemanns organizer
Secreted proteins
title_short Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
title_full Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
title_fullStr Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
title_full_unstemmed Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
title_sort Generating asymmetries in the early vertebrate embryo: the role of the Cerberus-like family
author Belo, José A.
author_facet Belo, José A.
Silva, Ana C.
Borges, Ana
Filipe, Mário
Bento, Margaret
Gonçalves, Lisa
Vitorino, Marta
Salgueiro, Ana Marisa
Texeira, Vera
Tavares, Ana T.
Marques, Sara
author_role author
author2 Silva, Ana C.
Borges, Ana
Filipe, Mário
Bento, Margaret
Gonçalves, Lisa
Vitorino, Marta
Salgueiro, Ana Marisa
Texeira, Vera
Tavares, Ana T.
Marques, Sara
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Belo, José A.
Silva, Ana C.
Borges, Ana
Filipe, Mário
Bento, Margaret
Gonçalves, Lisa
Vitorino, Marta
Salgueiro, Ana Marisa
Texeira, Vera
Tavares, Ana T.
Marques, Sara
dc.subject.por.fl_str_mv Anterior primitive endoderm
Mouse forebrain development
Visceral endoderm
Nodal expression
Xenopus embryos
Chick-embryo
Neuralizing activity
Lateral-inhibition
Spemanns organizer
Secreted proteins
topic Anterior primitive endoderm
Mouse forebrain development
Visceral endoderm
Nodal expression
Xenopus embryos
Chick-embryo
Neuralizing activity
Lateral-inhibition
Spemanns organizer
Secreted proteins
description One fundamental aspect of vertebrate embryonic development is the formation of the body plan. For this process, asymmetries have to be generated during early stages of development along the three main body axes: Anterior-Posterior, Dorso-Ventral and Left-Right. We have been studying the role of a novel class of molecules,the Cerberus/Dan gene family. These are dedicated secreted antagonists of three major signaling pathways: Nodal, BMP and Wnt. Our studies contribute to the current view that the fine tuning of signaling is controlled by a set of inhibitory molecules rather than by activators. In this context, the Cerberus-like molecules emerge as key players in the regulation and generation of asymmetries in the early vertebrate embryo.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
2018-12-07T14:58:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/12103
url http://hdl.handle.net/10400.1/12103
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0214-6282
10.1387/ijdb.072297jb
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv U B C Press
publisher.none.fl_str_mv U B C Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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