Histology-agnostic drugs: a paradigm shift: a narrative review

Detalhes bibliográficos
Autor(a) principal: Mansinho, André
Data de Publicação: 2022
Outros Autores: Fernandes, Ricardo M., Carneiro, António Vaz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/55290
Resumo: © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
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spelling Histology-agnostic drugs: a paradigm shift: a narrative reviewEarly drug developmentEnrichment designNew trial designPrecision medicineTissue-agnostic drug© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.Cancer diagnosis and therapeutics have been traditionally based on pathologic classification at the organ of origin. The availability of an unprecedented amount of clinical and biologic data provides a unique window of opportunity for the development of new drugs. What was once treated as a homogeneous disease with a one-size-fits-all approach was shown to be a rather heterogeneous condition, with multiple targetable mutations that can vary during the course of the disease. Clinical trial designs have had to adapt to the exponential growth of targetable mechanisms and new agents, with ensuing challenges that are closer to those experienced with rare diseases and orphan medicines. To face these problems, precision/enrichment and other novel trial designs have been developed, and the concept of histology-agnostic targeted therapeutic agents has emerged. Patients are selected for a specific agent based on specific genomic or molecular alterations, with the same compound used to potentially treat a multiplicity of cancers, granted that the actionable driver alteration is present. There are currently approved drugs for such indications, but this approach has raised issues on multiple levels. This review aims to address the challenges of this new concept and provide insights into possible solutions and frameworks on how to tackle them.Springer NatureRepositório da Universidade de LisboaMansinho, AndréFernandes, Ricardo M.Carneiro, António Vaz2022-11-29T16:00:17Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/55290engAdv Ther. 2022 Nov 230741-238X10.1007/s12325-022-02362-41865-8652info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:02:08Zoai:repositorio.ul.pt:10451/55290Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:58.006754Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Histology-agnostic drugs: a paradigm shift: a narrative review
title Histology-agnostic drugs: a paradigm shift: a narrative review
spellingShingle Histology-agnostic drugs: a paradigm shift: a narrative review
Mansinho, André
Early drug development
Enrichment design
New trial design
Precision medicine
Tissue-agnostic drug
title_short Histology-agnostic drugs: a paradigm shift: a narrative review
title_full Histology-agnostic drugs: a paradigm shift: a narrative review
title_fullStr Histology-agnostic drugs: a paradigm shift: a narrative review
title_full_unstemmed Histology-agnostic drugs: a paradigm shift: a narrative review
title_sort Histology-agnostic drugs: a paradigm shift: a narrative review
author Mansinho, André
author_facet Mansinho, André
Fernandes, Ricardo M.
Carneiro, António Vaz
author_role author
author2 Fernandes, Ricardo M.
Carneiro, António Vaz
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Mansinho, André
Fernandes, Ricardo M.
Carneiro, António Vaz
dc.subject.por.fl_str_mv Early drug development
Enrichment design
New trial design
Precision medicine
Tissue-agnostic drug
topic Early drug development
Enrichment design
New trial design
Precision medicine
Tissue-agnostic drug
description © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-29T16:00:17Z
2022
2022-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/55290
url http://hdl.handle.net/10451/55290
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Adv Ther. 2022 Nov 23
0741-238X
10.1007/s12325-022-02362-4
1865-8652
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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