Anticonvulsant hypersensitivity syndrome in children.

Detalhes bibliográficos
Autor(a) principal: Pinheiro, Ana Ehrhardt
Data de Publicação: 2010
Outros Autores: Ferreira, Raquel, Ferreira, Gonçalo Cordeiro, Varandas, Luís
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681
Resumo: Anticonvulsant hypersensitivity syndrome, or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms), is a rare multisystem disorder, potentially fatal, that occurs after exposure to antiepileptic drugs, mainly aromatic ones. Clinically, this condition is recognized by the classic triad of fever, rash and internal organ involvement that usually develops 1 to 12 weeks after initiation of therapy. We report a case of a child treated with sodium valproate for epilepsy that showed a febrile rash 4 weeks after being medicated with phenobarbital. Laboratory testing revealed leukocytosis with eosinophilia elevated C-reactive protein and liver enzymes. Phenobarbital was suspended, with slow full recovery. This syndrome may mimic infectious, immunologic and neoplastic conditions, which may delay the correct diagnosis, but must be excluded in the presence of characteristic clinical features and drug exposition.
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spelling Anticonvulsant hypersensitivity syndrome in children.Síndrome de hipersensibilidade aos antiepilépticos na criança.Anticonvulsant hypersensitivity syndrome, or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms), is a rare multisystem disorder, potentially fatal, that occurs after exposure to antiepileptic drugs, mainly aromatic ones. Clinically, this condition is recognized by the classic triad of fever, rash and internal organ involvement that usually develops 1 to 12 weeks after initiation of therapy. We report a case of a child treated with sodium valproate for epilepsy that showed a febrile rash 4 weeks after being medicated with phenobarbital. Laboratory testing revealed leukocytosis with eosinophilia elevated C-reactive protein and liver enzymes. Phenobarbital was suspended, with slow full recovery. This syndrome may mimic infectious, immunologic and neoplastic conditions, which may delay the correct diagnosis, but must be excluded in the presence of characteristic clinical features and drug exposition.Anticonvulsant hypersensitivity syndrome, or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms), is a rare multisystem disorder, potentially fatal, that occurs after exposure to antiepileptic drugs, mainly aromatic ones. Clinically, this condition is recognized by the classic triad of fever, rash and internal organ involvement that usually develops 1 to 12 weeks after initiation of therapy. We report a case of a child treated with sodium valproate for epilepsy that showed a febrile rash 4 weeks after being medicated with phenobarbital. Laboratory testing revealed leukocytosis with eosinophilia elevated C-reactive protein and liver enzymes. Phenobarbital was suspended, with slow full recovery. This syndrome may mimic infectious, immunologic and neoplastic conditions, which may delay the correct diagnosis, but must be excluded in the presence of characteristic clinical features and drug exposition.Ordem dos Médicos2010-07-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681oai:ojs.www.actamedicaportuguesa.com:article/681Acta Médica Portuguesa; Vol. 23 No. 4 (2010): July-August; 715-8Acta Médica Portuguesa; Vol. 23 N.º 4 (2010): Julho-Agosto; 715-81646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681/359Pinheiro, Ana EhrhardtFerreira, RaquelFerreira, Gonçalo CordeiroVarandas, Luísinfo:eu-repo/semantics/openAccess2022-12-20T10:56:41Zoai:ojs.www.actamedicaportuguesa.com:article/681Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:16:40.574005Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anticonvulsant hypersensitivity syndrome in children.
Síndrome de hipersensibilidade aos antiepilépticos na criança.
title Anticonvulsant hypersensitivity syndrome in children.
spellingShingle Anticonvulsant hypersensitivity syndrome in children.
Pinheiro, Ana Ehrhardt
title_short Anticonvulsant hypersensitivity syndrome in children.
title_full Anticonvulsant hypersensitivity syndrome in children.
title_fullStr Anticonvulsant hypersensitivity syndrome in children.
title_full_unstemmed Anticonvulsant hypersensitivity syndrome in children.
title_sort Anticonvulsant hypersensitivity syndrome in children.
author Pinheiro, Ana Ehrhardt
author_facet Pinheiro, Ana Ehrhardt
Ferreira, Raquel
Ferreira, Gonçalo Cordeiro
Varandas, Luís
author_role author
author2 Ferreira, Raquel
Ferreira, Gonçalo Cordeiro
Varandas, Luís
author2_role author
author
author
dc.contributor.author.fl_str_mv Pinheiro, Ana Ehrhardt
Ferreira, Raquel
Ferreira, Gonçalo Cordeiro
Varandas, Luís
description Anticonvulsant hypersensitivity syndrome, or DRESS (Drug Rash with Eosinophilia and Systemic Symptoms), is a rare multisystem disorder, potentially fatal, that occurs after exposure to antiepileptic drugs, mainly aromatic ones. Clinically, this condition is recognized by the classic triad of fever, rash and internal organ involvement that usually develops 1 to 12 weeks after initiation of therapy. We report a case of a child treated with sodium valproate for epilepsy that showed a febrile rash 4 weeks after being medicated with phenobarbital. Laboratory testing revealed leukocytosis with eosinophilia elevated C-reactive protein and liver enzymes. Phenobarbital was suspended, with slow full recovery. This syndrome may mimic infectious, immunologic and neoplastic conditions, which may delay the correct diagnosis, but must be excluded in the presence of characteristic clinical features and drug exposition.
publishDate 2010
dc.date.none.fl_str_mv 2010-07-30
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681
oai:ojs.www.actamedicaportuguesa.com:article/681
url https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681
identifier_str_mv oai:ojs.www.actamedicaportuguesa.com:article/681
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/681/359
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ordem dos Médicos
publisher.none.fl_str_mv Ordem dos Médicos
dc.source.none.fl_str_mv Acta Médica Portuguesa; Vol. 23 No. 4 (2010): July-August; 715-8
Acta Médica Portuguesa; Vol. 23 N.º 4 (2010): Julho-Agosto; 715-8
1646-0758
0870-399X
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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