Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.26/20044 |
Resumo: | This is the accepted version of the following article: J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):1799-1807, which has been published in final form at http://dx.doi.org/10.1002/jbm.b.33715. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html]. |
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Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effectSoft contact lensesLiposomesDrug releaseEyelidFrictionThis is the accepted version of the following article: J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):1799-1807, which has been published in final form at http://dx.doi.org/10.1002/jbm.b.33715. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html].In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DMPC + cholesterol (DMPC + CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.WileyRepositório ComumParadiso, P.Colaço, R.Mata, J. L. G.Krastev, R.Saramago, B.Serro, A. P.2018-10-31T01:30:12Z2017-10-01T00:00:00Z2017-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/20044engParadiso P, Colaço R, Mata JLG, Krastev R, Saramago B, Serro AP. 2017. Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect. J Biomed Mater Res Part B 2017:105B:1799–1807. DOI 10.1002/jbm.b.337151552-498110.1002/jbm.b.33715info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:13Zoai:comum.rcaap.pt:10400.26/20044Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:08.892708Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| title |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| spellingShingle |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect Paradiso, P. Soft contact lenses Liposomes Drug release Eyelid Friction |
| title_short |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| title_full |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| title_fullStr |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| title_full_unstemmed |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| title_sort |
Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect |
| author |
Paradiso, P. |
| author_facet |
Paradiso, P. Colaço, R. Mata, J. L. G. Krastev, R. Saramago, B. Serro, A. P. |
| author_role |
author |
| author2 |
Colaço, R. Mata, J. L. G. Krastev, R. Saramago, B. Serro, A. P. |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Comum |
| dc.contributor.author.fl_str_mv |
Paradiso, P. Colaço, R. Mata, J. L. G. Krastev, R. Saramago, B. Serro, A. P. |
| dc.subject.por.fl_str_mv |
Soft contact lenses Liposomes Drug release Eyelid Friction |
| topic |
Soft contact lenses Liposomes Drug release Eyelid Friction |
| description |
This is the accepted version of the following article: J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):1799-1807, which has been published in final form at http://dx.doi.org/10.1002/jbm.b.33715. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html]. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017-10-01T00:00:00Z 2017-10-01T00:00:00Z 2018-10-31T01:30:12Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.26/20044 |
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http://hdl.handle.net/10400.26/20044 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Paradiso P, Colaço R, Mata JLG, Krastev R, Saramago B, Serro AP. 2017. Drug release from liposome coated hydrogels for soft contact lenses: the blinking and temperature effect. J Biomed Mater Res Part B 2017:105B:1799–1807. DOI 10.1002/jbm.b.33715 1552-4981 10.1002/jbm.b.33715 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Wiley |
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Wiley |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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