Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/54404 |
Resumo: | Copyright © 2022 Silva-Costa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
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Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019)Streptococcus pneumoniaeDiagnosticsEpidemiologyNucleic acid technologyPediatric infectious diseasePneumoniaSerotypesVaccinesCopyright © 2022 Silva-Costa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.We previously reported that despite the use of pneumococcal conjugate vaccines (PCVs), vaccine serotypes remained important causes of pneumonia with pleural effusion and empyema (pediatric complicated pneumococcal pneumonia [PCPP]). We cultured and performed PCR on 174 pleural fluid samples recovered from pediatric patients in Portugal from 2016 to 2019 to identify and serotype Streptococcus pneumoniae. Most PCPP cases (n = 87/98) were identified by PCR only. Serotypes 3 (67%), 14, and 8 (5% each) were the most frequent. Vaccine breakthrough cases were seen among age-appropriately, 13-valent, PCV vaccinated children (median: 3 years, range: 17 months to 7 years), mostly with serotype 3 (n = 27) but also with serotypes 14 and 19A (n = 2 each). One breakthrough was seen with serotype 14 in an age-appropriately, 10-valent, PCV-vaccinated child and another with serotype 3 in a child to whom the 23-valent polysaccharide vaccine was administered. While the relative risk of serotype 1 PCPP decreased almost 10-fold from the period of 2010 to 2015 to the period of 2016 to 2019 (relative risk [RR] = 0.106), that of serotype 3 PCPP almost doubled (RR = 1.835). Our data highlight the importance of molecular diagnostics in identifying PCPP and document the continued importance of serotype 3 PCPP, even when PCV13 use with almost universal coverage could be expected to reduce exposure to this serotype. IMPORTANCE The use of conjugate vaccines against Streptococcus pneumoniae in children has led to substantial reductions in pneumococcal invasive disease. However, the reductions seen in each of the 13 serotypes currently included in the highest-valency vaccine approved for use in children (PCV13), were not the same. It is becoming clear that most vaccine breakthroughs worldwide involve serotype 3 and are frequently associated with complicated pneumonia cases, often with empyema or pleural effusion. Here, we show that despite almost universal PCV13 use, which would be expected to reduce vaccine serotype circulation and further reinforce vaccine direct protection, pneumococci and serotype 3 remain the major causes of pediatric complicated pneumonia. Molecular methods are essential to identify and serotype pneumococci in these cases, which frequently reflect vaccine breakthroughs. A broader use of molecular diagnostics will be essential to determine the role of this important serotype in the context of PCV13 use in different geographic regions.Partial support was received from the Fundação para a Ciência e a Tecnologia (PTDC/DTP-EPI/1555/2014) and from an investigator-initiated grant from Pfizer.American Society for MicrobiologyRepositório da Universidade de LisboaSilva-Costa, CatarinaSilva, JoanaPinho, Marcos DanielFriães, AnaRamirez, MárioCristino, José MeloOliveira, Laura Andrade de2022-09-09T11:21:22Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/54404engMicrobiol Spectr. 2022 Aug 31;10(4):e010772210.1128/spectrum.01077-222165-0497info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:00:42Zoai:repositorio.ul.pt:10451/54404Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:05:11.374801Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| title |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| spellingShingle |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) Silva-Costa, Catarina Streptococcus pneumoniae Diagnostics Epidemiology Nucleic acid technology Pediatric infectious disease Pneumonia Serotypes Vaccines |
| title_short |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| title_full |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| title_fullStr |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| title_full_unstemmed |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| title_sort |
Continued vaccine breakthrough cases of serotype 3 complicated pneumonia in vaccinated children, Portugal (2016–2019) |
| author |
Silva-Costa, Catarina |
| author_facet |
Silva-Costa, Catarina Silva, Joana Pinho, Marcos Daniel Friães, Ana Ramirez, Mário Cristino, José Melo Oliveira, Laura Andrade de |
| author_role |
author |
| author2 |
Silva, Joana Pinho, Marcos Daniel Friães, Ana Ramirez, Mário Cristino, José Melo Oliveira, Laura Andrade de |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Silva-Costa, Catarina Silva, Joana Pinho, Marcos Daniel Friães, Ana Ramirez, Mário Cristino, José Melo Oliveira, Laura Andrade de |
| dc.subject.por.fl_str_mv |
Streptococcus pneumoniae Diagnostics Epidemiology Nucleic acid technology Pediatric infectious disease Pneumonia Serotypes Vaccines |
| topic |
Streptococcus pneumoniae Diagnostics Epidemiology Nucleic acid technology Pediatric infectious disease Pneumonia Serotypes Vaccines |
| description |
Copyright © 2022 Silva-Costa et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09-09T11:21:22Z 2022 2022-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/54404 |
| url |
http://hdl.handle.net/10451/54404 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Microbiol Spectr. 2022 Aug 31;10(4):e0107722 10.1128/spectrum.01077-22 2165-0497 |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
American Society for Microbiology |
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American Society for Microbiology |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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