State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks

Detalhes bibliográficos
Autor(a) principal: García-Torra, Victor
Data de Publicação: 2021
Outros Autores: Cano, Amanda, Espina, Marta, Ettcheto, Miren, Camins, Antoni, Barroso, Emma, Vazquez-Carrera, Manel, García, Maria Luisa, Sánchez-López, Elena, Souto, Eliana B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/105501
https://doi.org/10.3390/toxics9080195
Resumo: Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained.
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spelling State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risksmetal nanoparticlesnanoparticles toxicityreactive oxygen speciesnanoparticles functionalizationMetal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained.MDPI2021-08-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/105501http://hdl.handle.net/10316/105501https://doi.org/10.3390/toxics9080195eng2305-6304García-Torra, VictorCano, AmandaEspina, MartaEttcheto, MirenCamins, AntoniBarroso, EmmaVazquez-Carrera, ManelGarcía, Maria LuisaSánchez-López, ElenaSouto, Eliana B.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-03T09:11:23Zoai:estudogeral.uc.pt:10316/105501Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:03.787332Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
title State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
spellingShingle State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
García-Torra, Victor
metal nanoparticles
nanoparticles toxicity
reactive oxygen species
nanoparticles functionalization
title_short State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
title_full State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
title_fullStr State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
title_full_unstemmed State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
title_sort State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
author García-Torra, Victor
author_facet García-Torra, Victor
Cano, Amanda
Espina, Marta
Ettcheto, Miren
Camins, Antoni
Barroso, Emma
Vazquez-Carrera, Manel
García, Maria Luisa
Sánchez-López, Elena
Souto, Eliana B.
author_role author
author2 Cano, Amanda
Espina, Marta
Ettcheto, Miren
Camins, Antoni
Barroso, Emma
Vazquez-Carrera, Manel
García, Maria Luisa
Sánchez-López, Elena
Souto, Eliana B.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv García-Torra, Victor
Cano, Amanda
Espina, Marta
Ettcheto, Miren
Camins, Antoni
Barroso, Emma
Vazquez-Carrera, Manel
García, Maria Luisa
Sánchez-López, Elena
Souto, Eliana B.
dc.subject.por.fl_str_mv metal nanoparticles
nanoparticles toxicity
reactive oxygen species
nanoparticles functionalization
topic metal nanoparticles
nanoparticles toxicity
reactive oxygen species
nanoparticles functionalization
description Metal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of metal nanoparticles. Parameters involved in their toxicity such as size, surface charge and concentration are also highlighted. Moreover, a critical revision of the literature about the strategies used to reduce the toxicity of this type of nanoparticles is carried out throughout the review. Additionally, surface modifications using different coating strategies, nanoparticles targeting and morphology modifications are deeply explained.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-23
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/105501
http://hdl.handle.net/10316/105501
https://doi.org/10.3390/toxics9080195
url http://hdl.handle.net/10316/105501
https://doi.org/10.3390/toxics9080195
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2305-6304
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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