Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research.
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/36356 https://doi.org/10.3390/vetsci10060379 |
Resumo: | Breast cancer is one of the most common and well-known types of cancer among women worldwide and is the most frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas female rats are currently the most widely used animal models for breast cancer research in the laboratory context. Both female dogs and female rats have contributed to the advancement of scientific knowledge in this field, and, in a “One Health” approach, they have allowed broad understanding of specific biopathological pathways, influence of environmental factors and screening/discovery of candidate therapies. This review aims to clearly showcase the similarities and differences among woman, female dog and female rat concerning to anatomical, physiological and histological features of the mammary gland and breast/mammary cancer epidemiology, in order to better portray breast tumorigenesis, and to ensure appropriate conclusions and extrapolation of results among species. We also discuss the major aspects that stand out in these species. The mammary glands of female dogs and women share structural similarities, especially with respect to the lactiferous ducts and lymphatic drainage. In contrast, female rats have only one lactiferous duct per nipple. A comprehensive comparison between humans and dogs is given a special focus, as these species share several aspects in terms of breast/mammary cancer epidemiology, such as age of onset, hormonal etiology, risk factors, and the clinical course of the disease. Holistically, it is clear that each species has advantages and limitations that researchers must consider during the development of experimental designs and data analysis. |
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Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research.Breast cancer is one of the most common and well-known types of cancer among women worldwide and is the most frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas female rats are currently the most widely used animal models for breast cancer research in the laboratory context. Both female dogs and female rats have contributed to the advancement of scientific knowledge in this field, and, in a “One Health” approach, they have allowed broad understanding of specific biopathological pathways, influence of environmental factors and screening/discovery of candidate therapies. This review aims to clearly showcase the similarities and differences among woman, female dog and female rat concerning to anatomical, physiological and histological features of the mammary gland and breast/mammary cancer epidemiology, in order to better portray breast tumorigenesis, and to ensure appropriate conclusions and extrapolation of results among species. We also discuss the major aspects that stand out in these species. The mammary glands of female dogs and women share structural similarities, especially with respect to the lactiferous ducts and lymphatic drainage. In contrast, female rats have only one lactiferous duct per nipple. A comprehensive comparison between humans and dogs is given a special focus, as these species share several aspects in terms of breast/mammary cancer epidemiology, such as age of onset, hormonal etiology, risk factors, and the clinical course of the disease. Holistically, it is clear that each species has advantages and limitations that researchers must consider during the development of experimental designs and data analysis.Veterinary Sciences2024-03-11T17:13:41Z2024-03-112023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/36356http://hdl.handle.net/10174/36356https://doi.org/10.3390/vetsci10060379engFerreira T, Gama A, Seixas F, Faustino-Rocha AI, Lopes C, Gaspar VM, Mano J, Medeiros R, Oliveira PA. 2023. Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. Veterinary Sciences 10(6): 379. Doi: 10.3390/vetsci10060379. https://www.mdpi.com/2306-7381/10/6/379/htmhttps://www.mdpi.com/2306-7381/10/6/379/htmndndndndndndndndndFerreira, TGama, ASeixas, FFaustino-Rocha, AILopes, CGaspar, VMMano, JMedeiros, ROliveira, PAinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-12T01:46:49Zoai:dspace.uevora.pt:10174/36356Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T04:00:25.868123Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
title |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
spellingShingle |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. Ferreira, T |
title_short |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
title_full |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
title_fullStr |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
title_full_unstemmed |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
title_sort |
Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. |
author |
Ferreira, T |
author_facet |
Ferreira, T Gama, A Seixas, F Faustino-Rocha, AI Lopes, C Gaspar, VM Mano, J Medeiros, R Oliveira, PA |
author_role |
author |
author2 |
Gama, A Seixas, F Faustino-Rocha, AI Lopes, C Gaspar, VM Mano, J Medeiros, R Oliveira, PA |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Ferreira, T Gama, A Seixas, F Faustino-Rocha, AI Lopes, C Gaspar, VM Mano, J Medeiros, R Oliveira, PA |
description |
Breast cancer is one of the most common and well-known types of cancer among women worldwide and is the most frequent neoplasm in intact female dogs. Female dogs are considered attractive models or studying spontaneous breast cancer, whereas female rats are currently the most widely used animal models for breast cancer research in the laboratory context. Both female dogs and female rats have contributed to the advancement of scientific knowledge in this field, and, in a “One Health” approach, they have allowed broad understanding of specific biopathological pathways, influence of environmental factors and screening/discovery of candidate therapies. This review aims to clearly showcase the similarities and differences among woman, female dog and female rat concerning to anatomical, physiological and histological features of the mammary gland and breast/mammary cancer epidemiology, in order to better portray breast tumorigenesis, and to ensure appropriate conclusions and extrapolation of results among species. We also discuss the major aspects that stand out in these species. The mammary glands of female dogs and women share structural similarities, especially with respect to the lactiferous ducts and lymphatic drainage. In contrast, female rats have only one lactiferous duct per nipple. A comprehensive comparison between humans and dogs is given a special focus, as these species share several aspects in terms of breast/mammary cancer epidemiology, such as age of onset, hormonal etiology, risk factors, and the clinical course of the disease. Holistically, it is clear that each species has advantages and limitations that researchers must consider during the development of experimental designs and data analysis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-01T00:00:00Z 2024-03-11T17:13:41Z 2024-03-11 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/36356 http://hdl.handle.net/10174/36356 https://doi.org/10.3390/vetsci10060379 |
url |
http://hdl.handle.net/10174/36356 https://doi.org/10.3390/vetsci10060379 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Ferreira T, Gama A, Seixas F, Faustino-Rocha AI, Lopes C, Gaspar VM, Mano J, Medeiros R, Oliveira PA. 2023. Mammary glands of women, female dogs and female rats: similarities and differences to be considered in breast cancer research. Veterinary Sciences 10(6): 379. Doi: 10.3390/vetsci10060379. https://www.mdpi.com/2306-7381/10/6/379/htm https://www.mdpi.com/2306-7381/10/6/379/htm nd nd nd nd nd nd nd nd nd |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Veterinary Sciences |
publisher.none.fl_str_mv |
Veterinary Sciences |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138180081909760 |