Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/23678 |
Resumo: | Staphylococcus aureus is both a human commensal and a pathogen, that causes serious nosocomial and community-acquired infections. Despite nostrils being considered its preferred host habitat, the oral cavity has been demonstrated to be an ideal starting point for auto-infection and transmission. The antibiotic resistance assessment of S. aureus is a priority and is often reported in clinical settings. This study aimed to explore the prevalence and antimicrobial susceptibility of S. aureus in the oral and nasal cavities of healthy individuals. The participants (n = 101) were subjected to a demographic and clinical background survey, a caries evaluation, and to oral and nasal swabbing. Swabs were cultured in differential/selective media and S. aureus isolates were identified (MALDI-TOF MS) and tested for antibiotic susceptibility (EUCAST/CLSI). Similar S. aureus prevalence was found exclusively on nasal (13.9%) or oral (12.0%) habitats, whereas 9.9% of the population were simultaneous nasal and oral carriers. In oro-nasal cavities, similar antibiotic resistance rates (83.3–81.5%), including MDR (20.8–29.6%), were observed. Notably, 60% (6/10) of the simultaneous nasal and oral carriers exhibited different antibiotic resistance profiles between cavities. This study demonstrates the relevance of the oral cavity as an independent colonization site for S. aureus and as a potential source of antimicrobial resistance, a role which has been widely neglected so far. |
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Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistanceStaphylococcus aureusOro-nasal carriageAntibiotic resistanceMultidrug-resistanceHealthy individualsStaphylococcus aureus is both a human commensal and a pathogen, that causes serious nosocomial and community-acquired infections. Despite nostrils being considered its preferred host habitat, the oral cavity has been demonstrated to be an ideal starting point for auto-infection and transmission. The antibiotic resistance assessment of S. aureus is a priority and is often reported in clinical settings. This study aimed to explore the prevalence and antimicrobial susceptibility of S. aureus in the oral and nasal cavities of healthy individuals. The participants (n = 101) were subjected to a demographic and clinical background survey, a caries evaluation, and to oral and nasal swabbing. Swabs were cultured in differential/selective media and S. aureus isolates were identified (MALDI-TOF MS) and tested for antibiotic susceptibility (EUCAST/CLSI). Similar S. aureus prevalence was found exclusively on nasal (13.9%) or oral (12.0%) habitats, whereas 9.9% of the population were simultaneous nasal and oral carriers. In oro-nasal cavities, similar antibiotic resistance rates (83.3–81.5%), including MDR (20.8–29.6%), were observed. Notably, 60% (6/10) of the simultaneous nasal and oral carriers exhibited different antibiotic resistance profiles between cavities. This study demonstrates the relevance of the oral cavity as an independent colonization site for S. aureus and as a potential source of antimicrobial resistance, a role which has been widely neglected so far.MDPIRepositório Científico do Instituto Politécnico do PortoCampos, JoanaFaria Pires, MarianaSousa, MartaCampos, CarlaFernandes Ferreira Alves da Costa, CarolinaSampaio-Maia, Benedita2023-10-11T17:05:27Z2023-05-262023-05-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/23678engCampos, J., Pires, M. F., Sousa, M., Campos, C., da Costa, C. F. F. A., & Sampaio-Maia, B. (2023). Unveiling the Relevance of the Oral Cavity as a Staphylococcus aureus Colonization Site and Potential Source of Antimicrobial Resistance. Pathogens, 12(6), Artigo 6. https://doi.org/10.3390/pathogens1206076510.3390/pathogens12060765 2076-0817info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-18T01:45:57Zoai:recipp.ipp.pt:10400.22/23678Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:35:52.151696Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
title |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
spellingShingle |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance Campos, Joana Staphylococcus aureus Oro-nasal carriage Antibiotic resistance Multidrug-resistance Healthy individuals |
title_short |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
title_full |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
title_fullStr |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
title_full_unstemmed |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
title_sort |
Unveiling the relevance of the oral cavity as a staphylococcus aureus colonization site and potential source of antimicrobial resistance |
author |
Campos, Joana |
author_facet |
Campos, Joana Faria Pires, Mariana Sousa, Marta Campos, Carla Fernandes Ferreira Alves da Costa, Carolina Sampaio-Maia, Benedita |
author_role |
author |
author2 |
Faria Pires, Mariana Sousa, Marta Campos, Carla Fernandes Ferreira Alves da Costa, Carolina Sampaio-Maia, Benedita |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Campos, Joana Faria Pires, Mariana Sousa, Marta Campos, Carla Fernandes Ferreira Alves da Costa, Carolina Sampaio-Maia, Benedita |
dc.subject.por.fl_str_mv |
Staphylococcus aureus Oro-nasal carriage Antibiotic resistance Multidrug-resistance Healthy individuals |
topic |
Staphylococcus aureus Oro-nasal carriage Antibiotic resistance Multidrug-resistance Healthy individuals |
description |
Staphylococcus aureus is both a human commensal and a pathogen, that causes serious nosocomial and community-acquired infections. Despite nostrils being considered its preferred host habitat, the oral cavity has been demonstrated to be an ideal starting point for auto-infection and transmission. The antibiotic resistance assessment of S. aureus is a priority and is often reported in clinical settings. This study aimed to explore the prevalence and antimicrobial susceptibility of S. aureus in the oral and nasal cavities of healthy individuals. The participants (n = 101) were subjected to a demographic and clinical background survey, a caries evaluation, and to oral and nasal swabbing. Swabs were cultured in differential/selective media and S. aureus isolates were identified (MALDI-TOF MS) and tested for antibiotic susceptibility (EUCAST/CLSI). Similar S. aureus prevalence was found exclusively on nasal (13.9%) or oral (12.0%) habitats, whereas 9.9% of the population were simultaneous nasal and oral carriers. In oro-nasal cavities, similar antibiotic resistance rates (83.3–81.5%), including MDR (20.8–29.6%), were observed. Notably, 60% (6/10) of the simultaneous nasal and oral carriers exhibited different antibiotic resistance profiles between cavities. This study demonstrates the relevance of the oral cavity as an independent colonization site for S. aureus and as a potential source of antimicrobial resistance, a role which has been widely neglected so far. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-11T17:05:27Z 2023-05-26 2023-05-26T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/23678 |
url |
http://hdl.handle.net/10400.22/23678 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Campos, J., Pires, M. F., Sousa, M., Campos, C., da Costa, C. F. F. A., & Sampaio-Maia, B. (2023). Unveiling the Relevance of the Oral Cavity as a Staphylococcus aureus Colonization Site and Potential Source of Antimicrobial Resistance. Pathogens, 12(6), Artigo 6. https://doi.org/10.3390/pathogens12060765 10.3390/pathogens12060765 2076-0817 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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