Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results

Detalhes bibliográficos
Autor(a) principal: Ângelo, David Faustino
Data de Publicação: 2018
Outros Autores: Morouço, Pedro, Gil, Florêncio Monje, Mónico, Lisete, González-Garcia, Raúl, Sousa, Rita, Neto, Lia, Caldeira, Inês, Smith, Margaret, Smith, Susan, Sanz, David, Santos, Fábio Abade dos, Pinho, Mário, Carrapiço, Belmira, Cavaco, Sandra, Moura, Carla, Alves, Nuno, Salvado, Francisco, Little, Christopher
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/8446
Resumo: This study was granted by Portuguese Grunenthal Foundation, Secção Regional Oeste da Ordem dos Médicos, Sociedade Anatómica Portuguesa e Associação Anatómica Portuguesa.
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spelling Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight resultsPreclinical studyTMJ discectomyTMJ discopexyTMJ imagingTMJ histologyTMJ discThis study was granted by Portuguese Grunenthal Foundation, Secção Regional Oeste da Ordem dos Médicos, Sociedade Anatómica Portuguesa e Associação Anatómica Portuguesa.Introduction: The role of temporomandibular joint (TMJ) surgery is not well defined due to a lack of quality randomized controlled clinical trials, comparing different TMJ surgical treatments with medical and placebo interventions. The temporomandibular joint interposal study (TEMPOJIMS) is a rigorous preclinical trial divided in 2 phases. In phase 1 the authors investigated the role of the TMJ disc and in phase 2 the authors evaluated 3 different interposal materials. The present work of TEMPOJIMS e phase 1, aims to evaluate histopathologic and imaging changes of bilateral discectomy and discopexy in Black Merino sheep TMJ, using a high-quality trial following the ARRIVE guidelines. Material and methods: This randomized, blinded and controlled preclinical trial was conducted in 9 Black Merino sheep to investigate histopathologic (primary outcome), imaging and body weight (secondary outcomes) changes after bilateral discectomy, discopexy and sham surgery. Results: Significant changes were noticed in discectomy group, both in imaging and histopathologic analyses. Body weight changes were most pronounced in the discectomy group in the first 4 months after surgery with recovery to baseline weight 6 months after surgery. Discopexy induced nonsignificant changes in histopathologic, imaging and body weight analyses. Conclusions: This study reinforces the importance of developing an effective interposal material to substitute the TMJ disc and the need to explore the molecular mechanisms that underlie TMJ cartilage degeneration. The study design proposed in TEMPOJIMS represents an important progress towards future rigorous TMJ investigations.ElsevierIC-OnlineÂngelo, David FaustinoMorouço, PedroGil, Florêncio MonjeMónico, LiseteGonzález-Garcia, RaúlSousa, RitaNeto, LiaCaldeira, InêsSmith, MargaretSmith, SusanSanz, DavidSantos, Fábio Abade dosPinho, MárioCarrapiço, BelmiraCavaco, SandraMoura, CarlaAlves, NunoSalvado, FranciscoLittle, Christopher2023-04-24T13:13:42Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/8446engDavid Faustino Ângelo, Pedro Morouço, Florencio Monje Gil, Lisete Mónico, Raúl González-Gárcia, Rita Sousa, Lia Neto, Inês Caldeira, Margaret Smith, Susan Smith, David Sanz, Fábio Abade dos Santos, Mário Pinho, Belmira Carrapiço, Sandra Cavaco, Carla Moura, Nuno Alves, Francisco Salvado, Christopher Little, Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS – Phase 1- histologic, imaging and body weight results, Journal of Cranio-Maxillofacial Surgery, Volume 46, Issue 4, 2018, Pages 688-696, ISSN 1010-5182, https://doi.org/10.1016/j.jcms.2018.01.0061010-518210.1016/j.jcms.2018.01.006metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:57:19Zoai:iconline.ipleiria.pt:10400.8/8446Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:51:09.692174Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
title Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
spellingShingle Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
Ângelo, David Faustino
Preclinical study
TMJ discectomy
TMJ discopexy
TMJ imaging
TMJ histology
TMJ disc
title_short Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
title_full Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
title_fullStr Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
title_full_unstemmed Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
title_sort Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS e Phase 1- histologic, imaging and body weight results
author Ângelo, David Faustino
author_facet Ângelo, David Faustino
Morouço, Pedro
Gil, Florêncio Monje
Mónico, Lisete
González-Garcia, Raúl
Sousa, Rita
Neto, Lia
Caldeira, Inês
Smith, Margaret
Smith, Susan
Sanz, David
Santos, Fábio Abade dos
Pinho, Mário
Carrapiço, Belmira
Cavaco, Sandra
Moura, Carla
Alves, Nuno
Salvado, Francisco
Little, Christopher
author_role author
author2 Morouço, Pedro
Gil, Florêncio Monje
Mónico, Lisete
González-Garcia, Raúl
Sousa, Rita
Neto, Lia
Caldeira, Inês
Smith, Margaret
Smith, Susan
Sanz, David
Santos, Fábio Abade dos
Pinho, Mário
Carrapiço, Belmira
Cavaco, Sandra
Moura, Carla
Alves, Nuno
Salvado, Francisco
Little, Christopher
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Ângelo, David Faustino
Morouço, Pedro
Gil, Florêncio Monje
Mónico, Lisete
González-Garcia, Raúl
Sousa, Rita
Neto, Lia
Caldeira, Inês
Smith, Margaret
Smith, Susan
Sanz, David
Santos, Fábio Abade dos
Pinho, Mário
Carrapiço, Belmira
Cavaco, Sandra
Moura, Carla
Alves, Nuno
Salvado, Francisco
Little, Christopher
dc.subject.por.fl_str_mv Preclinical study
TMJ discectomy
TMJ discopexy
TMJ imaging
TMJ histology
TMJ disc
topic Preclinical study
TMJ discectomy
TMJ discopexy
TMJ imaging
TMJ histology
TMJ disc
description This study was granted by Portuguese Grunenthal Foundation, Secção Regional Oeste da Ordem dos Médicos, Sociedade Anatómica Portuguesa e Associação Anatómica Portuguesa.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2023-04-24T13:13:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/8446
url http://hdl.handle.net/10400.8/8446
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv David Faustino Ângelo, Pedro Morouço, Florencio Monje Gil, Lisete Mónico, Raúl González-Gárcia, Rita Sousa, Lia Neto, Inês Caldeira, Margaret Smith, Susan Smith, David Sanz, Fábio Abade dos Santos, Mário Pinho, Belmira Carrapiço, Sandra Cavaco, Carla Moura, Nuno Alves, Francisco Salvado, Christopher Little, Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS – Phase 1- histologic, imaging and body weight results, Journal of Cranio-Maxillofacial Surgery, Volume 46, Issue 4, 2018, Pages 688-696, ISSN 1010-5182, https://doi.org/10.1016/j.jcms.2018.01.006
1010-5182
10.1016/j.jcms.2018.01.006
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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