Biodegradable polymers: an update on drug delivery in bone and cartilage diseases

Detalhes bibliográficos
Autor(a) principal: Lima, Ana Cláudia Fernandes
Data de Publicação: 2019
Outros Autores: Ferreira, Helena Susana Costa Machado, Reis, R. L., Neves, N. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/62370
Resumo: Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.
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spelling Biodegradable polymers: an update on drug delivery in bone and cartilage diseasesBiodegradable polymersBone diseasesCartilage diseasescontrolled drug releaseDrug delivery systemsTargeted drug deliveryTissue engineeringScience & TechnologyIntroduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.Taylor & FrancisUniversidade do MinhoLima, Ana Cláudia FernandesFerreira, Helena Susana Costa MachadoReis, R. L.Neves, N. M.2019-072019-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62370engLima Ana C., Ferreira H., Reis R. L., Neves N. M. Biodegradable polymers: an update on drug delivery in bone and cartilage diseases, Expert Opinion on Drug Delivery, Vol. 16, Issue 8, pp. 795-813, doi:10.1080/17425247.2019.1635117, 20191742-52471744-759310.1080/17425247.2019.16351173122095810.1080/17425247.2019.1635117info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:59Zoai:repositorium.sdum.uminho.pt:1822/62370Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:53:29.436797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
title Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
spellingShingle Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
Lima, Ana Cláudia Fernandes
Biodegradable polymers
Bone diseases
Cartilage diseases
controlled drug release
Drug delivery systems
Targeted drug delivery
Tissue engineering
Science & Technology
title_short Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
title_full Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
title_fullStr Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
title_full_unstemmed Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
title_sort Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
author Lima, Ana Cláudia Fernandes
author_facet Lima, Ana Cláudia Fernandes
Ferreira, Helena Susana Costa Machado
Reis, R. L.
Neves, N. M.
author_role author
author2 Ferreira, Helena Susana Costa Machado
Reis, R. L.
Neves, N. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Lima, Ana Cláudia Fernandes
Ferreira, Helena Susana Costa Machado
Reis, R. L.
Neves, N. M.
dc.subject.por.fl_str_mv Biodegradable polymers
Bone diseases
Cartilage diseases
controlled drug release
Drug delivery systems
Targeted drug delivery
Tissue engineering
Science & Technology
topic Biodegradable polymers
Bone diseases
Cartilage diseases
controlled drug release
Drug delivery systems
Targeted drug delivery
Tissue engineering
Science & Technology
description Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.
publishDate 2019
dc.date.none.fl_str_mv 2019-07
2019-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/62370
url http://hdl.handle.net/1822/62370
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Lima Ana C., Ferreira H., Reis R. L., Neves N. M. Biodegradable polymers: an update on drug delivery in bone and cartilage diseases, Expert Opinion on Drug Delivery, Vol. 16, Issue 8, pp. 795-813, doi:10.1080/17425247.2019.1635117, 2019
1742-5247
1744-7593
10.1080/17425247.2019.1635117
31220958
10.1080/17425247.2019.1635117
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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