Biodegradable polymers: an update on drug delivery in bone and cartilage diseases
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62370 |
Resumo: | Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice. |
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Biodegradable polymers: an update on drug delivery in bone and cartilage diseasesBiodegradable polymersBone diseasesCartilage diseasescontrolled drug releaseDrug delivery systemsTargeted drug deliveryTissue engineeringScience & TechnologyIntroduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice.Taylor & FrancisUniversidade do MinhoLima, Ana Cláudia FernandesFerreira, Helena Susana Costa MachadoReis, R. L.Neves, N. M.2019-072019-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62370engLima Ana C., Ferreira H., Reis R. L., Neves N. M. Biodegradable polymers: an update on drug delivery in bone and cartilage diseases, Expert Opinion on Drug Delivery, Vol. 16, Issue 8, pp. 795-813, doi:10.1080/17425247.2019.1635117, 20191742-52471744-759310.1080/17425247.2019.16351173122095810.1080/17425247.2019.1635117info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:53:59Zoai:repositorium.sdum.uminho.pt:1822/62370Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:53:29.436797Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
title |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
spellingShingle |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases Lima, Ana Cláudia Fernandes Biodegradable polymers Bone diseases Cartilage diseases controlled drug release Drug delivery systems Targeted drug delivery Tissue engineering Science & Technology |
title_short |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
title_full |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
title_fullStr |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
title_full_unstemmed |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
title_sort |
Biodegradable polymers: an update on drug delivery in bone and cartilage diseases |
author |
Lima, Ana Cláudia Fernandes |
author_facet |
Lima, Ana Cláudia Fernandes Ferreira, Helena Susana Costa Machado Reis, R. L. Neves, N. M. |
author_role |
author |
author2 |
Ferreira, Helena Susana Costa Machado Reis, R. L. Neves, N. M. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Lima, Ana Cláudia Fernandes Ferreira, Helena Susana Costa Machado Reis, R. L. Neves, N. M. |
dc.subject.por.fl_str_mv |
Biodegradable polymers Bone diseases Cartilage diseases controlled drug release Drug delivery systems Targeted drug delivery Tissue engineering Science & Technology |
topic |
Biodegradable polymers Bone diseases Cartilage diseases controlled drug release Drug delivery systems Targeted drug delivery Tissue engineering Science & Technology |
description |
Introduction: The unique structure of bone and cartilage makes the systemic delivery of free drugs to those connective tissues very challenging. Consequently, effective and targeted delivery for bone and cartilage is of utmost importance. Engineered biodegradable polymers enable designing carriers for a targeted and temporal controlled release of one or more drugs in concentrations within the therapeutic range. Also, tissue engineering strategies can allow drug delivery to advantageously promote the in situ tissue repair. Areas covered: This review article highlights various drug delivery systems (DDS) based on biodegradable biomaterials to treat bone and/or cartilage diseases. We will review their applications in osteoporosis, inflammatory arthritis (namely osteoarthritis and rheumatoid arthritis), cancer and bone and cartilage tissue engineering. Expert opinion: The increased knowledge about biomaterials science and of the pathophysiology of diseases, biomarkers, and targets as well as the development of innovative tools has led to the design of high value-added DDS. However, some challenges persist and are mainly related to an appropriate residence time and a controlled and sustained release over a prolonged period of time of the therapeutic agents. Additionally, the poor prediction value of some preclinical animal models hinders the translation of many formulations into the clinical practice. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07 2019-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62370 |
url |
http://hdl.handle.net/1822/62370 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Lima Ana C., Ferreira H., Reis R. L., Neves N. M. Biodegradable polymers: an update on drug delivery in bone and cartilage diseases, Expert Opinion on Drug Delivery, Vol. 16, Issue 8, pp. 795-813, doi:10.1080/17425247.2019.1635117, 2019 1742-5247 1744-7593 10.1080/17425247.2019.1635117 31220958 10.1080/17425247.2019.1635117 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Taylor & Francis |
publisher.none.fl_str_mv |
Taylor & Francis |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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