Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery

Detalhes bibliográficos
Autor(a) principal: Souto, EB
Data de Publicação: 2004
Outros Autores: Wissing, SA, Barbosa, CM, Muller, RH
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/81223
Resumo: Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many Substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40degreesC. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.
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spelling Development of a controlled release formulation based on SLN and NLC for topical clotrimazole deliveryMedicina básicaBasic medicineSolid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many Substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40degreesC. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/81223eng0378-517310.1016/j.ijpharm.2004.02.032Souto, EBWissing, SABarbosa, CMMuller, RHinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:39:59Zoai:repositorio-aberto.up.pt:10216/81223Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:29:09.865443Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
title Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
spellingShingle Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
Souto, EB
Medicina básica
Basic medicine
title_short Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
title_full Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
title_fullStr Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
title_full_unstemmed Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
title_sort Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery
author Souto, EB
author_facet Souto, EB
Wissing, SA
Barbosa, CM
Muller, RH
author_role author
author2 Wissing, SA
Barbosa, CM
Muller, RH
author2_role author
author
author
dc.contributor.author.fl_str_mv Souto, EB
Wissing, SA
Barbosa, CM
Muller, RH
dc.subject.por.fl_str_mv Medicina básica
Basic medicine
topic Medicina básica
Basic medicine
description Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) are colloidal carrier systems providing controlled release profiles for many Substances. Clotrimazole-loaded SLN and NLC were prepared by the hot high pressure homogenization technique in order to evaluate the physical stability of these particles, as well as the entrapment efficiency of this lipophilic drug and its in vitro release profile. The particle size was analyzed by PCS and LD showing that the particles remained in their colloidal state during 3 months of storage at 4, 20 and 40degreesC. For all tested formulations the entrapment efficiency was higher than 50%. The obtained results also demonstrate the use of these lipid nanoparticles as modified release formulations for lipophilic drugs over a period of 10 h.
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/81223
url https://hdl.handle.net/10216/81223
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0378-5173
10.1016/j.ijpharm.2004.02.032
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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