Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.26537/citotech.v0i1.491 |
Resumo: | The present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study. |
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Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathologyCarcinoma neuroendócrino de pequenas células: um estudo de caso em citopatologia ginecológicaColpocytology;Small Cell Neuroendocrine CarcinomaColpocitologia;Carcinoma Neuroendócrino de Pequenas CélulasThe present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study.O presente estudo reporta o caso de uma mulher de 63 anos da qual a única informação clínica era a suspeita de um sarcoma da cérvix. Simultaneamente à colpocitologia, foram enviadas biópsias do colo e do endométrio para diagnóstico. A visualização da amostra citológica revelou vários agregados de número variável de células monótonas, com tamanho pequeno, formato redondo e citoplasma escasso, num fundo com diátese. Os núcleos apresentavam moldagem, hipercromasia, cromatina “sal-e-pimenta” e ausência de nucléolos. O aspeto microscópico das biópsias foi concordante com os achados citológicos, tendo sido igualmente identificados focos glanduliformes com características atípicas. A neoplasia mostrou expressão imunohistoquímica dos antigénios enolase neurónio-específica (neuron specific enolase, NSE), sinaptofisina e citoqueratina (clones AE1/AE3), e uma elevada atividade proliferativa demonstrada pela imunorreactividade para o marcador nuclear Ki67/Mib1. Os achados citológicos, histológicos e imunohistoquímicos foram consistentes com o diagnóstico de carcinoma neuroendócrino de pequenas células. Dos tumores cervicais, esta neoplasia maligna é das mais raras, mostrando um comportamento muito agressivo, com prognóstico muito pobre, em que as terapêuticas existentes são pouco consensuais quanto à sua eficácia. A sua etiologia ainda é estudada, podendo estar relacionada com a infeção pelo Vírus do Papiloma Humano.Escola de Superior de Saúde | Instituto Politécnico do Porto2015-06-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.26537/citotech.v0i1.491oai:oai.parc.ipp.pt:article/491Citotech Online - Case Review; No. 1 (2015): Citotech Online - Case Review; 1-7Citotech Online - Case Review; N.º 1 (2015): Citotech Online - Case Review; 1-72183-735Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPengporhttps://parc.ipp.pt/index.php/citotech/article/view/491https://doi.org/10.26537/citotech.v0i1.491https://parc.ipp.pt/index.php/citotech/article/view/491/1651https://parc.ipp.pt/index.php/citotech/article/view/491/216Copyright (c) 2017 Citotech Online - Case Reviewhttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMachado, Bruno GomesAntunes, LuísMendonça, Paula2022-09-20T11:09:44Zoai:oai.parc.ipp.pt:article/491Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:49:04.051581Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology Carcinoma neuroendócrino de pequenas células: um estudo de caso em citopatologia ginecológica |
title |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology |
spellingShingle |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology Machado, Bruno Gomes Colpocytology; Small Cell Neuroendocrine Carcinoma Colpocitologia; Carcinoma Neuroendócrino de Pequenas Células |
title_short |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology |
title_full |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology |
title_fullStr |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology |
title_full_unstemmed |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology |
title_sort |
Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology |
author |
Machado, Bruno Gomes |
author_facet |
Machado, Bruno Gomes Antunes, Luís Mendonça, Paula |
author_role |
author |
author2 |
Antunes, Luís Mendonça, Paula |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Machado, Bruno Gomes Antunes, Luís Mendonça, Paula |
dc.subject.por.fl_str_mv |
Colpocytology; Small Cell Neuroendocrine Carcinoma Colpocitologia; Carcinoma Neuroendócrino de Pequenas Células |
topic |
Colpocytology; Small Cell Neuroendocrine Carcinoma Colpocitologia; Carcinoma Neuroendócrino de Pequenas Células |
description |
The present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-16T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.26537/citotech.v0i1.491 oai:oai.parc.ipp.pt:article/491 |
url |
https://doi.org/10.26537/citotech.v0i1.491 |
identifier_str_mv |
oai:oai.parc.ipp.pt:article/491 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
https://parc.ipp.pt/index.php/citotech/article/view/491 https://doi.org/10.26537/citotech.v0i1.491 https://parc.ipp.pt/index.php/citotech/article/view/491/1651 https://parc.ipp.pt/index.php/citotech/article/view/491/216 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2017 Citotech Online - Case Review https://creativecommons.org/licenses/by-nc-nd/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2017 Citotech Online - Case Review https://creativecommons.org/licenses/by-nc-nd/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Escola de Superior de Saúde | Instituto Politécnico do Porto |
publisher.none.fl_str_mv |
Escola de Superior de Saúde | Instituto Politécnico do Porto |
dc.source.none.fl_str_mv |
Citotech Online - Case Review; No. 1 (2015): Citotech Online - Case Review; 1-7 Citotech Online - Case Review; N.º 1 (2015): Citotech Online - Case Review; 1-7 2183-735X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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