Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology

Detalhes bibliográficos
Autor(a) principal: Machado, Bruno Gomes
Data de Publicação: 2015
Outros Autores: Antunes, Luís, Mendonça, Paula
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.26537/citotech.v0i1.491
Resumo: The present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study.
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spelling Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathologyCarcinoma neuroendócrino de pequenas células: um estudo de caso em citopatologia ginecológicaColpocytology;Small Cell Neuroendocrine CarcinomaColpocitologia;Carcinoma Neuroendócrino de Pequenas CélulasThe present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study.O presente estudo reporta o caso de uma mulher de 63 anos da qual a única informação clínica era a suspeita de um sarcoma da cérvix. Simultaneamente à colpocitologia, foram enviadas biópsias do colo e do endométrio para diagnóstico. A visualização da amostra citológica revelou vários agregados de número variável de células monótonas, com tamanho pequeno, formato redondo e citoplasma escasso, num fundo com diátese. Os núcleos apresentavam moldagem, hipercromasia, cromatina “sal-e-pimenta” e ausência de nucléolos. O aspeto microscópico das biópsias foi concordante com os achados citológicos, tendo sido igualmente identificados focos glanduliformes com características atípicas. A neoplasia mostrou expressão imunohistoquímica dos antigénios enolase neurónio-específica (neuron specific enolase, NSE), sinaptofisina e citoqueratina (clones AE1/AE3), e uma elevada atividade proliferativa demonstrada pela imunorreactividade para o marcador nuclear Ki67/Mib1. Os achados citológicos, histológicos e imunohistoquímicos foram consistentes com o diagnóstico de carcinoma neuroendócrino de pequenas células. Dos tumores cervicais, esta neoplasia maligna é das mais raras, mostrando um comportamento muito agressivo, com prognóstico muito pobre, em que as terapêuticas existentes são pouco consensuais quanto à sua eficácia. A sua etiologia ainda é estudada, podendo estar relacionada com a infeção pelo Vírus do Papiloma Humano.Escola de Superior de Saúde | Instituto Politécnico do Porto2015-06-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://doi.org/10.26537/citotech.v0i1.491oai:oai.parc.ipp.pt:article/491Citotech Online - Case Review; No. 1 (2015): Citotech Online - Case Review; 1-7Citotech Online - Case Review; N.º 1 (2015): Citotech Online - Case Review; 1-72183-735Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPengporhttps://parc.ipp.pt/index.php/citotech/article/view/491https://doi.org/10.26537/citotech.v0i1.491https://parc.ipp.pt/index.php/citotech/article/view/491/1651https://parc.ipp.pt/index.php/citotech/article/view/491/216Copyright (c) 2017 Citotech Online - Case Reviewhttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessMachado, Bruno GomesAntunes, LuísMendonça, Paula2022-09-20T11:09:44Zoai:oai.parc.ipp.pt:article/491Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:49:04.051581Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
Carcinoma neuroendócrino de pequenas células: um estudo de caso em citopatologia ginecológica
title Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
spellingShingle Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
Machado, Bruno Gomes
Colpocytology;
Small Cell Neuroendocrine Carcinoma
Colpocitologia;
Carcinoma Neuroendócrino de Pequenas Células
title_short Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
title_full Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
title_fullStr Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
title_full_unstemmed Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
title_sort Small cell neuroendocrine carcinoma: a case study in gynecologic cytopathology
author Machado, Bruno Gomes
author_facet Machado, Bruno Gomes
Antunes, Luís
Mendonça, Paula
author_role author
author2 Antunes, Luís
Mendonça, Paula
author2_role author
author
dc.contributor.author.fl_str_mv Machado, Bruno Gomes
Antunes, Luís
Mendonça, Paula
dc.subject.por.fl_str_mv Colpocytology;
Small Cell Neuroendocrine Carcinoma
Colpocitologia;
Carcinoma Neuroendócrino de Pequenas Células
topic Colpocytology;
Small Cell Neuroendocrine Carcinoma
Colpocitologia;
Carcinoma Neuroendócrino de Pequenas Células
description The present study shows the case of a 62 years old woman, whose only clinical data was a suspected cervical sarcoma. A liquid-based cytology and biopsies from the cervix and the endometrium were done and sent for diagnostic laboratory. The cytology showed numerous groups of a variable number of monotonous, small and round cells, having scarce cytoplasm in a diathesis background. The nuclei featured molding, hyperchromasia, “salt-and-pepper” chromatin and no nucleoli. Similar observations could be found with the biopsies, where atypical gland-like groups were also detected. This neoplasia showed positive immunostaining for neuron specific enolase, synaptophysin and cytokeratin (AE1/AE3 clone antibodies), and a proliferative activity demonstrated by the nuclear marker Ki67/Mib1 immunorreactivity. The cytological, histological and imunohistochemical findings were consistent with the diagnosis of a small cell neuroendocrine carcinoma. Of all the cervical tumors, this sort of malignancy is one of the rarest and has a very aggressive behavior, with poor prognosis and without effective treatment. Its cause may be related to the Human Papillomavirus infection, but this still remains in study.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-16T00:00:00Z
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dc.relation.none.fl_str_mv https://parc.ipp.pt/index.php/citotech/article/view/491
https://doi.org/10.26537/citotech.v0i1.491
https://parc.ipp.pt/index.php/citotech/article/view/491/1651
https://parc.ipp.pt/index.php/citotech/article/view/491/216
dc.rights.driver.fl_str_mv Copyright (c) 2017 Citotech Online - Case Review
https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Citotech Online - Case Review
https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Escola de Superior de Saúde | Instituto Politécnico do Porto
publisher.none.fl_str_mv Escola de Superior de Saúde | Instituto Politécnico do Porto
dc.source.none.fl_str_mv Citotech Online - Case Review; No. 1 (2015): Citotech Online - Case Review; 1-7
Citotech Online - Case Review; N.º 1 (2015): Citotech Online - Case Review; 1-7
2183-735X
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