Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF

Detalhes bibliográficos
Autor(a) principal: Brito, Pedro
Data de Publicação: 2018
Outros Autores: Costa, Jorge, Gomes, Nuno, Costa, Sandra, Correia-Pinto, Jorge, Silva, Rufino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/58083
Resumo: Accepted manuscript
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spelling Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGFAnti-VEGFBevacizumabC-reactive proteinDiabetic macular edemaInflammatory biomarkersCiências Médicas::Medicina BásicaScience & TechnologyAccepted manuscriptTo study the relationship between systemic pro-inflammatory factors and macular structural response to intravitreal bevacizumab for diabetic macular edema (DME).Purpose To study the relationship between systemic pro-inflammatory factors and macular structural response to intravitreal bevacizumab for diabetic macular edema (DME). Methods Prospective study including 30 cases with DME, treated with bevacizumab and a minimum follow-up of 6 months. All cases underwent baseline laboratory testing for cardiovascular risk (high sensitivity C-reactive protein (hsCRP), homocystein), dyslipidemia, renal dysfunction and glucose control. Serum levels of VEGF, soluble ICAM-1, MCP-1 and TNF-α were assessed by enzyme-linked immunosorbent assay kits. Significant associations between systemic factors and quantitative and qualitative spectral-domain optical coherence macular features were analyzed. Results A mean of 4.82 ± 0.56 intravitreal injections was performed, resulting in significant improvement of central foveal thickness (CFT) (p < 0.001). A significant association with third month CFT decrease <10% was found for hsCRP (3.33 ± 2.01 vs 1.39 ± 1.15 mg/l, p = 0.007) and ICAM1 (975.54 ± 265.49 vs 727.07 ± 336.09 pg/ml, p = 0.012). ROC curve analysis indicated hsCRP and ICAM1 as significant biomarkers for 3rd month reduced anatomic response (area under the curve (AUC) = 0.807, p = 0.009 for hsCRP; AUC = 0.788, p = 0.014 for ICAM1). ROC curve analysis revealed hsCRP as a significant biomarker for 6th month CFT decrease <10% (AUC = 0.903, p < 0.001, cutoff value = 1.81 mg/l). A significant association with 6th month CFT decrease ≥25% was found for serum MCP1 (244.69 ± 49.34 pg/ml vs 319.24 ± 94.88 pg/ml, p = 0.017) and serum VEGF (90.84 ± 37.33 vs 58.28 ± 25.19 pg/ml, p = 0.027). The combined model of serum VEGF and LDL-cholesterol was found to be predictive of 6th month hard exudate severity (p = 0.001, r2 = 0.463). Conclusions Increased levels of hsCRP and ICAM1 were found to be significant biomarkers for early reduced anatomic response to anti-VEGF treatment. Cases with higher serum levels of such factors had increased CFT values, despite treatment, suggesting inner blood-retinal barrier breakdown that is not adequately responsive to anti-VEGF monotherapyPortuguese Society of Ophthalmologyinfo:eu-repo/semantics/publishedVersionElsevier Science IncUniversidade do MinhoBrito, PedroCosta, JorgeGomes, NunoCosta, SandraCorreia-Pinto, JorgeSilva, Rufino2018-072018-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/58083engBrito, P., Costa, J., Gomes, N., Costa, S., Correia-Pinto, J., & Silva, R. (2018). Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF. Journal of diabetes and its complications1056-872710.1016/j.jdiacomp.2018.05.006https://www.sciencedirect.com/science/article/pii/S105687271830148Xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:48:32Zoai:repositorium.sdum.uminho.pt:1822/58083Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:46:48.313626Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
title Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
spellingShingle Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
Brito, Pedro
Anti-VEGF
Bevacizumab
C-reactive protein
Diabetic macular edema
Inflammatory biomarkers
Ciências Médicas::Medicina Básica
Science & Technology
title_short Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
title_full Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
title_fullStr Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
title_full_unstemmed Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
title_sort Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF
author Brito, Pedro
author_facet Brito, Pedro
Costa, Jorge
Gomes, Nuno
Costa, Sandra
Correia-Pinto, Jorge
Silva, Rufino
author_role author
author2 Costa, Jorge
Gomes, Nuno
Costa, Sandra
Correia-Pinto, Jorge
Silva, Rufino
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Brito, Pedro
Costa, Jorge
Gomes, Nuno
Costa, Sandra
Correia-Pinto, Jorge
Silva, Rufino
dc.subject.por.fl_str_mv Anti-VEGF
Bevacizumab
C-reactive protein
Diabetic macular edema
Inflammatory biomarkers
Ciências Médicas::Medicina Básica
Science & Technology
topic Anti-VEGF
Bevacizumab
C-reactive protein
Diabetic macular edema
Inflammatory biomarkers
Ciências Médicas::Medicina Básica
Science & Technology
description Accepted manuscript
publishDate 2018
dc.date.none.fl_str_mv 2018-07
2018-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/58083
url http://hdl.handle.net/1822/58083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brito, P., Costa, J., Gomes, N., Costa, S., Correia-Pinto, J., & Silva, R. (2018). Serological inflammatory factors as biomarkers for anatomic response in diabetic macular edema treated with anti-VEGF. Journal of diabetes and its complications
1056-8727
10.1016/j.jdiacomp.2018.05.006
https://www.sciencedirect.com/science/article/pii/S105687271830148X
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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