Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications

Detalhes bibliográficos
Autor(a) principal: Rakotonirina-Ricquebourg, R
Data de Publicação: 2021
Outros Autores: Costa, V, Teixeira, V
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/137614
Resumo: Lipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to physiological and environmental cues. The identification of several neutral lipid synthesizing and regulatory protein complexes have propelled significant advance on the mechanisms of LD biogenesis in the endoplasmic reticulum (ER). Increasing evidence suggests that distinct proteins and regulatory factors, which localize to membrane contact sites (MCS), are involved not only in interorganellar lipid exchange and transport, but also function in other important cellular processes, including autophagy, mitochondrial dynamics and inheritance, ion signaling and inter-regulation of these MCS. More and more tethers and molecular determinants are associated to MCS and to a diversity of cellular and pathophysiological processes, demonstrating the dynamics and importance of these junctions in health and disease. The conjugation of lipids with proteins in supramolecular complexes is known to be paramount for many biological processes, namely membrane biosynthesis, cell homeostasis, regulation of organelle division and biogenesis, and cell growth. Ultimately, this physical organization allows the contact sites to function as crucial metabolic hubs that control the occurrence of chemical reactions. This leads to biochemical and metabolite compartmentalization for the purposes of energetic efficiency and cellular homeostasis. In this review, we will focus on the structural and functional aspects of LD-organelle interactions and how they ensure signaling exchange and metabolites transfer between organelles.
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spelling Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implicationsLipid dropletMembrane contact sitesMembrane biogenesisInterorganellar communicationMolecular tetherMetabolismLipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to physiological and environmental cues. The identification of several neutral lipid synthesizing and regulatory protein complexes have propelled significant advance on the mechanisms of LD biogenesis in the endoplasmic reticulum (ER). Increasing evidence suggests that distinct proteins and regulatory factors, which localize to membrane contact sites (MCS), are involved not only in interorganellar lipid exchange and transport, but also function in other important cellular processes, including autophagy, mitochondrial dynamics and inheritance, ion signaling and inter-regulation of these MCS. More and more tethers and molecular determinants are associated to MCS and to a diversity of cellular and pathophysiological processes, demonstrating the dynamics and importance of these junctions in health and disease. The conjugation of lipids with proteins in supramolecular complexes is known to be paramount for many biological processes, namely membrane biosynthesis, cell homeostasis, regulation of organelle division and biogenesis, and cell growth. Ultimately, this physical organization allows the contact sites to function as crucial metabolic hubs that control the occurrence of chemical reactions. This leads to biochemical and metabolite compartmentalization for the purposes of energetic efficiency and cellular homeostasis. In this review, we will focus on the structural and functional aspects of LD-organelle interactions and how they ensure signaling exchange and metabolites transfer between organelles.Elsevier2021-11-162021-11-16T00:00:00Z2022-11-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/137614eng0163-782710.1016/j.plipres.2021.101141Rakotonirina-Ricquebourg, RCosta, VTeixeira, Vinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T14:38:50Zoai:repositorio-aberto.up.pt:10216/137614Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:05:56.762540Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
title Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
spellingShingle Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
Rakotonirina-Ricquebourg, R
Lipid droplet
Membrane contact sites
Membrane biogenesis
Interorganellar communication
Molecular tether
Metabolism
title_short Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
title_full Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
title_fullStr Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
title_full_unstemmed Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
title_sort Hello from the other side: Membrane contact of lipid droplets with other organelles and subsequent functional implications
author Rakotonirina-Ricquebourg, R
author_facet Rakotonirina-Ricquebourg, R
Costa, V
Teixeira, V
author_role author
author2 Costa, V
Teixeira, V
author2_role author
author
dc.contributor.author.fl_str_mv Rakotonirina-Ricquebourg, R
Costa, V
Teixeira, V
dc.subject.por.fl_str_mv Lipid droplet
Membrane contact sites
Membrane biogenesis
Interorganellar communication
Molecular tether
Metabolism
topic Lipid droplet
Membrane contact sites
Membrane biogenesis
Interorganellar communication
Molecular tether
Metabolism
description Lipid droplets (LDs) are ubiquitous organelles that play crucial roles in response to physiological and environmental cues. The identification of several neutral lipid synthesizing and regulatory protein complexes have propelled significant advance on the mechanisms of LD biogenesis in the endoplasmic reticulum (ER). Increasing evidence suggests that distinct proteins and regulatory factors, which localize to membrane contact sites (MCS), are involved not only in interorganellar lipid exchange and transport, but also function in other important cellular processes, including autophagy, mitochondrial dynamics and inheritance, ion signaling and inter-regulation of these MCS. More and more tethers and molecular determinants are associated to MCS and to a diversity of cellular and pathophysiological processes, demonstrating the dynamics and importance of these junctions in health and disease. The conjugation of lipids with proteins in supramolecular complexes is known to be paramount for many biological processes, namely membrane biosynthesis, cell homeostasis, regulation of organelle division and biogenesis, and cell growth. Ultimately, this physical organization allows the contact sites to function as crucial metabolic hubs that control the occurrence of chemical reactions. This leads to biochemical and metabolite compartmentalization for the purposes of energetic efficiency and cellular homeostasis. In this review, we will focus on the structural and functional aspects of LD-organelle interactions and how they ensure signaling exchange and metabolites transfer between organelles.
publishDate 2021
dc.date.none.fl_str_mv 2021-11-16
2021-11-16T00:00:00Z
2022-11-16T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/137614
url https://hdl.handle.net/10216/137614
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0163-7827
10.1016/j.plipres.2021.101141
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
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