Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report

Detalhes bibliográficos
Autor(a) principal: Oliveira,Ana Isabel
Data de Publicação: 2023
Outros Autores: Azevedo,Ana, Cunha,Teresa Stock da, Góis,Mário, Pidal,Ana
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200112
Resumo: ABSTRACT Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was performed, showing minimal change disease with lymphomatous infiltration of B-lymphocytes CD20+. Therapy with bortezomib, dexametahasone and rituximab was started and after 6 months of follow-up he presented progressive recovery of renal function and remission of proteinuria. This case illustrates the importance of screening renal disease in WM patients. A kidney biopsy should be performed in those presenting with otherwise unexplained renal failure and/or nephrotic syndrome.
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spelling Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case ReportBiopsyKidney/pathologyNephrotic SyndromeWaldenstrom MacroglobulinemiaABSTRACT Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was performed, showing minimal change disease with lymphomatous infiltration of B-lymphocytes CD20+. Therapy with bortezomib, dexametahasone and rituximab was started and after 6 months of follow-up he presented progressive recovery of renal function and remission of proteinuria. This case illustrates the importance of screening renal disease in WM patients. A kidney biopsy should be performed in those presenting with otherwise unexplained renal failure and/or nephrotic syndrome.Sociedade Portuguesa de Nefrologia2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporttext/htmlhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200112Portuguese Journal of Nephrology & Hypertension v.37 n.2 2023reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200112Oliveira,Ana IsabelAzevedo,AnaCunha,Teresa Stock daGóis,MárioPidal,Anainfo:eu-repo/semantics/openAccess2024-02-06T17:05:17Zoai:scielo:S0872-01692023000200112Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:19:10.035301Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
title Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
spellingShingle Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
Oliveira,Ana Isabel
Biopsy
Kidney/pathology
Nephrotic Syndrome
Waldenstrom Macroglobulinemia
title_short Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
title_full Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
title_fullStr Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
title_full_unstemmed Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
title_sort Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
author Oliveira,Ana Isabel
author_facet Oliveira,Ana Isabel
Azevedo,Ana
Cunha,Teresa Stock da
Góis,Mário
Pidal,Ana
author_role author
author2 Azevedo,Ana
Cunha,Teresa Stock da
Góis,Mário
Pidal,Ana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Ana Isabel
Azevedo,Ana
Cunha,Teresa Stock da
Góis,Mário
Pidal,Ana
dc.subject.por.fl_str_mv Biopsy
Kidney/pathology
Nephrotic Syndrome
Waldenstrom Macroglobulinemia
topic Biopsy
Kidney/pathology
Nephrotic Syndrome
Waldenstrom Macroglobulinemia
description ABSTRACT Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was performed, showing minimal change disease with lymphomatous infiltration of B-lymphocytes CD20+. Therapy with bortezomib, dexametahasone and rituximab was started and after 6 months of follow-up he presented progressive recovery of renal function and remission of proteinuria. This case illustrates the importance of screening renal disease in WM patients. A kidney biopsy should be performed in those presenting with otherwise unexplained renal failure and/or nephrotic syndrome.
publishDate 2023
dc.date.none.fl_str_mv 2023-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200112
url http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200112
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692023000200112
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
publisher.none.fl_str_mv Sociedade Portuguesa de Nefrologia
dc.source.none.fl_str_mv Portuguese Journal of Nephrology & Hypertension v.37 n.2 2023
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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