Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/1822/85094 |
Resumo: | Additive manufacturing advancements contribute considerably to several fields, and its use in the medical field is gaining attention due to its easily customizable option (patient-specific), low cost, and fast turnout time in developing drug delivery and diagnostic tools. Here, wereport the fabrication of a microneedle (MN) platform using a stereolithography 3D printer, varying the 3D printing angle and aspect ratio (2:1, 3:1, 4:1). The optimal printing angle was30, resulting in needle tip and base diameters of 50 µm and 330 µm, and heights of 550/850/1180 µm. Polyvinyl alcohol (PVA) MNs produced with varying levofloxacin concentrations showed variability of 4% in tip and 3% base diameters and 15% in height compared to the 3D-printed MNs. Geometry B wasused to produce levofloxacin-loaded PVA MNs and tested against Klebsiella pneumoniae colony biofilms. Levofloxacin wasreleased gradually, as assessed by spectrofluorimetry. The MIC of levofloxacin against the K. pneumoniae clinical isolate was4 µg/mL, but this concentration wasinsufficient to cause any effect on K. pneumoniae biofilms. Only concentrations 32 µg/mL werestatistically different compared to the unloaded MNs. 3D printing is an attractive solution to produce molds for fabricating biopolymeric MNs for topical drug delivery. |
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Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control3D printingbiofilmsKlebsiella pneumoniaelevofloxacinmicroneedlespolyvinyl alcoholScience & TechnologyAdditive manufacturing advancements contribute considerably to several fields, and its use in the medical field is gaining attention due to its easily customizable option (patient-specific), low cost, and fast turnout time in developing drug delivery and diagnostic tools. Here, wereport the fabrication of a microneedle (MN) platform using a stereolithography 3D printer, varying the 3D printing angle and aspect ratio (2:1, 3:1, 4:1). The optimal printing angle was30, resulting in needle tip and base diameters of 50 µm and 330 µm, and heights of 550/850/1180 µm. Polyvinyl alcohol (PVA) MNs produced with varying levofloxacin concentrations showed variability of 4% in tip and 3% base diameters and 15% in height compared to the 3D-printed MNs. Geometry B wasused to produce levofloxacin-loaded PVA MNs and tested against Klebsiella pneumoniae colony biofilms. Levofloxacin wasreleased gradually, as assessed by spectrofluorimetry. The MIC of levofloxacin against the K. pneumoniae clinical isolate was4 µg/mL, but this concentration wasinsufficient to cause any effect on K. pneumoniae biofilms. Only concentrations 32 µg/mL werestatistically different compared to the unloaded MNs. 3D printing is an attractive solution to produce molds for fabricating biopolymeric MNs for topical drug delivery.S.S. acknowledges funding by FCT through the individual scientific employment program contract (2020.03171.CEECIND). The radius was corrected to diameter on June 12, 2023.info:eu-repo/semantics/publishedVersionWileyUniversidade do MinhoVinayakumar, K. B.Silva, Maria DanielaMartins, ArturMundy, StephenGonzález-Losada, PedroSillankorva, Sanna M.2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/85094engVinayakumar, K. B.; Silva, Maria Daniela; Martins, Artur; Mundy, Stephen; González-Losada, Pedro; Sillankorva, Sanna M., Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control. Advanced Therapeutics, 6(6), 2200320, 20232366-398710.1002/adtp.202200320https://onlinelibrary.wiley.com/doi/10.1002/adtp.202200320info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-23T01:28:41Zoai:repositorium.sdum.uminho.pt:1822/85094Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:40.874141Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
title |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
spellingShingle |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control Vinayakumar, K. B. 3D printing biofilms Klebsiella pneumoniae levofloxacin microneedles polyvinyl alcohol Science & Technology |
title_short |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
title_full |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
title_fullStr |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
title_full_unstemmed |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
title_sort |
Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control |
author |
Vinayakumar, K. B. |
author_facet |
Vinayakumar, K. B. Silva, Maria Daniela Martins, Artur Mundy, Stephen González-Losada, Pedro Sillankorva, Sanna M. |
author_role |
author |
author2 |
Silva, Maria Daniela Martins, Artur Mundy, Stephen González-Losada, Pedro Sillankorva, Sanna M. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Vinayakumar, K. B. Silva, Maria Daniela Martins, Artur Mundy, Stephen González-Losada, Pedro Sillankorva, Sanna M. |
dc.subject.por.fl_str_mv |
3D printing biofilms Klebsiella pneumoniae levofloxacin microneedles polyvinyl alcohol Science & Technology |
topic |
3D printing biofilms Klebsiella pneumoniae levofloxacin microneedles polyvinyl alcohol Science & Technology |
description |
Additive manufacturing advancements contribute considerably to several fields, and its use in the medical field is gaining attention due to its easily customizable option (patient-specific), low cost, and fast turnout time in developing drug delivery and diagnostic tools. Here, wereport the fabrication of a microneedle (MN) platform using a stereolithography 3D printer, varying the 3D printing angle and aspect ratio (2:1, 3:1, 4:1). The optimal printing angle was30, resulting in needle tip and base diameters of 50 µm and 330 µm, and heights of 550/850/1180 µm. Polyvinyl alcohol (PVA) MNs produced with varying levofloxacin concentrations showed variability of 4% in tip and 3% base diameters and 15% in height compared to the 3D-printed MNs. Geometry B wasused to produce levofloxacin-loaded PVA MNs and tested against Klebsiella pneumoniae colony biofilms. Levofloxacin wasreleased gradually, as assessed by spectrofluorimetry. The MIC of levofloxacin against the K. pneumoniae clinical isolate was4 µg/mL, but this concentration wasinsufficient to cause any effect on K. pneumoniae biofilms. Only concentrations 32 µg/mL werestatistically different compared to the unloaded MNs. 3D printing is an attractive solution to produce molds for fabricating biopolymeric MNs for topical drug delivery. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-06 2023-06-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/1822/85094 |
url |
https://hdl.handle.net/1822/85094 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Vinayakumar, K. B.; Silva, Maria Daniela; Martins, Artur; Mundy, Stephen; González-Losada, Pedro; Sillankorva, Sanna M., Levofloxacin-loaded microneedles produced using 3D-printed molds for Klebsiella pneumoniae biofilm control. Advanced Therapeutics, 6(6), 2200320, 2023 2366-3987 10.1002/adtp.202200320 https://onlinelibrary.wiley.com/doi/10.1002/adtp.202200320 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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