Effect of Month of Birth on the Risk of Developing Psoriasis

Detalhes bibliográficos
Autor(a) principal: Martins, Ana
Data de Publicação: 2018
Outros Autores: Bettencourt, Andreia, Torres, Tiago
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.29021/spdv.75.4.872
Resumo: Introduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis.Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032).Results: Birth rate of psoriasis patients decreased in October (OR 0.74; 95% CI 0.55 – 0.99; p 0.041). After Bonferroni correction and after grouping the months by trimesters, no statistical significant differences were found.Conclusion: Our results may be related to the particular meteorological characteristics of Portugal that may lead to stabilization of the vitamin D synthesis during the whole year. The perception of the environmental influence on the development of a specific pathology is very important because it allows the establishment of preventive measures that will reduce disease incidence. 
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spelling Effect of Month of Birth on the Risk of Developing PsoriasisEfeito do Mês de Nascimento no Risco de Desenvolver PsoríasePsoriasisRisk Factors SeasonsSunlightUltraviolet RaysVitamin DEstaçõesFactores de RiscoLuz SolarPsoríaseRaios UltravioletaVitamina DIntroduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis.Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032).Results: Birth rate of psoriasis patients decreased in October (OR 0.74; 95% CI 0.55 – 0.99; p 0.041). After Bonferroni correction and after grouping the months by trimesters, no statistical significant differences were found.Conclusion: Our results may be related to the particular meteorological characteristics of Portugal that may lead to stabilization of the vitamin D synthesis during the whole year. The perception of the environmental influence on the development of a specific pathology is very important because it allows the establishment of preventive measures that will reduce disease incidence. Introdução: A psoríase é uma dermatose imunomediada caraterizada por inflamação crónica, proliferação e diferenciação anormal dos queratinócitos, hiperplasia vascular e infiltração de células inflamatórias. É uma doença multifatorial influenciada por alterações genéticas e epigenéticas despoletadas por estímulos ambientais. O clima e a exposição solar parecem afetar a prevalência da psoríase e a radiação ultravioleta é útil na abordagem terapêutica. O nosso objectivo foi avaliar a influência do mês de nascimento (como marcador da época de gestação) no risco de desenvolver psoríase.Métodos: Comparação da distribuição dos meses de nascimentos nos pacientes com psoríase (n = 755) seguidos no Centro Hospitalar e Universitário do Porto com uma população controlo constituída pelos cidadãos portugueses nascidos no mesmo período e área geográfica dos pacientes com psoríase (n = 6 560 032).Resultados: Observou-se uma diminuição do número de nascimentos de pacientes com psoríase no mês de outubro estatisticamente significativa (OR 0,74; 95% CI 0,55 – 0,99; p 0,041). Após correção de Bonferroni e após agrupar os meses por trimestres, não se observaram diferenças estatisticamente significativas.Conclusão: As diferenças estatísticas pouco significativas e não significativas apresentadas podem ser explicadas pelas características meteorológicas particulares de Portugal que podem tornar a síntese de vitamina D relativamente estável durante o ano. A perceção da influência ambiental no desenvolvimento de determinada patologia é importante porque permite o estabelecimento de medidas preventivas que conduzirão à diminuição da sua incidência.Sociedade Portuguesa de Dermatologia e Venereologia2018-01-26T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.75.4.872oai:ojs.revista.spdv.com.pt:article/872Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 4 (2017): Outubro - Dezembro; 337-342Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 4 (2017): Outubro - Dezembro; 337-3422182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/872https://doi.org/10.29021/spdv.75.4.872https://revista.spdv.com.pt/index.php/spdv/article/view/872/524Martins, AnaBettencourt, AndreiaTorres, Tiagoinfo:eu-repo/semantics/openAccess2022-10-06T12:35:06Zoai:ojs.revista.spdv.com.pt:article/872Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:05.335487Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of Month of Birth on the Risk of Developing Psoriasis
Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase
title Effect of Month of Birth on the Risk of Developing Psoriasis
spellingShingle Effect of Month of Birth on the Risk of Developing Psoriasis
Martins, Ana
Psoriasis
Risk Factors Seasons
Sunlight
Ultraviolet Rays
Vitamin D
Estações
Factores de Risco
Luz Solar
Psoríase
Raios Ultravioleta
Vitamina D
title_short Effect of Month of Birth on the Risk of Developing Psoriasis
title_full Effect of Month of Birth on the Risk of Developing Psoriasis
title_fullStr Effect of Month of Birth on the Risk of Developing Psoriasis
title_full_unstemmed Effect of Month of Birth on the Risk of Developing Psoriasis
title_sort Effect of Month of Birth on the Risk of Developing Psoriasis
author Martins, Ana
author_facet Martins, Ana
Bettencourt, Andreia
Torres, Tiago
author_role author
author2 Bettencourt, Andreia
Torres, Tiago
author2_role author
author
dc.contributor.author.fl_str_mv Martins, Ana
Bettencourt, Andreia
Torres, Tiago
dc.subject.por.fl_str_mv Psoriasis
Risk Factors Seasons
Sunlight
Ultraviolet Rays
Vitamin D
Estações
Factores de Risco
Luz Solar
Psoríase
Raios Ultravioleta
Vitamina D
topic Psoriasis
Risk Factors Seasons
Sunlight
Ultraviolet Rays
Vitamin D
Estações
Factores de Risco
Luz Solar
Psoríase
Raios Ultravioleta
Vitamina D
description Introduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis.Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032).Results: Birth rate of psoriasis patients decreased in October (OR 0.74; 95% CI 0.55 – 0.99; p 0.041). After Bonferroni correction and after grouping the months by trimesters, no statistical significant differences were found.Conclusion: Our results may be related to the particular meteorological characteristics of Portugal that may lead to stabilization of the vitamin D synthesis during the whole year. The perception of the environmental influence on the development of a specific pathology is very important because it allows the establishment of preventive measures that will reduce disease incidence. 
publishDate 2018
dc.date.none.fl_str_mv 2018-01-26T00:00:00Z
dc.type.driver.fl_str_mv journal article
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dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.29021/spdv.75.4.872
oai:ojs.revista.spdv.com.pt:article/872
url https://doi.org/10.29021/spdv.75.4.872
identifier_str_mv oai:ojs.revista.spdv.com.pt:article/872
dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://revista.spdv.com.pt/index.php/spdv/article/view/872
https://doi.org/10.29021/spdv.75.4.872
https://revista.spdv.com.pt/index.php/spdv/article/view/872/524
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
publisher.none.fl_str_mv Sociedade Portuguesa de Dermatologia e Venereologia
dc.source.none.fl_str_mv Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 4 (2017): Outubro - Dezembro; 337-342
Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 4 (2017): Outubro - Dezembro; 337-342
2182-2409
2182-2395
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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