Effect of Month of Birth on the Risk of Developing Psoriasis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.75.4.872 |
Resumo: | Introduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis.Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032).Results: Birth rate of psoriasis patients decreased in October (OR 0.74; 95% CI 0.55 – 0.99; p 0.041). After Bonferroni correction and after grouping the months by trimesters, no statistical significant differences were found.Conclusion: Our results may be related to the particular meteorological characteristics of Portugal that may lead to stabilization of the vitamin D synthesis during the whole year. The perception of the environmental influence on the development of a specific pathology is very important because it allows the establishment of preventive measures that will reduce disease incidence. |
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Effect of Month of Birth on the Risk of Developing PsoriasisEfeito do Mês de Nascimento no Risco de Desenvolver PsoríasePsoriasisRisk Factors SeasonsSunlightUltraviolet RaysVitamin DEstaçõesFactores de RiscoLuz SolarPsoríaseRaios UltravioletaVitamina DIntroduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis.Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032).Results: Birth rate of psoriasis patients decreased in October (OR 0.74; 95% CI 0.55 – 0.99; p 0.041). After Bonferroni correction and after grouping the months by trimesters, no statistical significant differences were found.Conclusion: Our results may be related to the particular meteorological characteristics of Portugal that may lead to stabilization of the vitamin D synthesis during the whole year. The perception of the environmental influence on the development of a specific pathology is very important because it allows the establishment of preventive measures that will reduce disease incidence. Introdução: A psoríase é uma dermatose imunomediada caraterizada por inflamação crónica, proliferação e diferenciação anormal dos queratinócitos, hiperplasia vascular e infiltração de células inflamatórias. É uma doença multifatorial influenciada por alterações genéticas e epigenéticas despoletadas por estímulos ambientais. O clima e a exposição solar parecem afetar a prevalência da psoríase e a radiação ultravioleta é útil na abordagem terapêutica. O nosso objectivo foi avaliar a influência do mês de nascimento (como marcador da época de gestação) no risco de desenvolver psoríase.Métodos: Comparação da distribuição dos meses de nascimentos nos pacientes com psoríase (n = 755) seguidos no Centro Hospitalar e Universitário do Porto com uma população controlo constituída pelos cidadãos portugueses nascidos no mesmo período e área geográfica dos pacientes com psoríase (n = 6 560 032).Resultados: Observou-se uma diminuição do número de nascimentos de pacientes com psoríase no mês de outubro estatisticamente significativa (OR 0,74; 95% CI 0,55 – 0,99; p 0,041). Após correção de Bonferroni e após agrupar os meses por trimestres, não se observaram diferenças estatisticamente significativas.Conclusão: As diferenças estatísticas pouco significativas e não significativas apresentadas podem ser explicadas pelas características meteorológicas particulares de Portugal que podem tornar a síntese de vitamina D relativamente estável durante o ano. A perceção da influência ambiental no desenvolvimento de determinada patologia é importante porque permite o estabelecimento de medidas preventivas que conduzirão à diminuição da sua incidência.Sociedade Portuguesa de Dermatologia e Venereologia2018-01-26T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.75.4.872oai:ojs.revista.spdv.com.pt:article/872Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 4 (2017): Outubro - Dezembro; 337-342Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 4 (2017): Outubro - Dezembro; 337-3422182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spdv.com.pt/index.php/spdv/article/view/872https://doi.org/10.29021/spdv.75.4.872https://revista.spdv.com.pt/index.php/spdv/article/view/872/524Martins, AnaBettencourt, AndreiaTorres, Tiagoinfo:eu-repo/semantics/openAccess2022-10-06T12:35:06Zoai:ojs.revista.spdv.com.pt:article/872Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:05.335487Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effect of Month of Birth on the Risk of Developing Psoriasis Efeito do Mês de Nascimento no Risco de Desenvolver Psoríase |
title |
Effect of Month of Birth on the Risk of Developing Psoriasis |
spellingShingle |
Effect of Month of Birth on the Risk of Developing Psoriasis Martins, Ana Psoriasis Risk Factors Seasons Sunlight Ultraviolet Rays Vitamin D Estações Factores de Risco Luz Solar Psoríase Raios Ultravioleta Vitamina D |
title_short |
Effect of Month of Birth on the Risk of Developing Psoriasis |
title_full |
Effect of Month of Birth on the Risk of Developing Psoriasis |
title_fullStr |
Effect of Month of Birth on the Risk of Developing Psoriasis |
title_full_unstemmed |
Effect of Month of Birth on the Risk of Developing Psoriasis |
title_sort |
Effect of Month of Birth on the Risk of Developing Psoriasis |
author |
Martins, Ana |
author_facet |
Martins, Ana Bettencourt, Andreia Torres, Tiago |
author_role |
author |
author2 |
Bettencourt, Andreia Torres, Tiago |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Martins, Ana Bettencourt, Andreia Torres, Tiago |
dc.subject.por.fl_str_mv |
Psoriasis Risk Factors Seasons Sunlight Ultraviolet Rays Vitamin D Estações Factores de Risco Luz Solar Psoríase Raios Ultravioleta Vitamina D |
topic |
Psoriasis Risk Factors Seasons Sunlight Ultraviolet Rays Vitamin D Estações Factores de Risco Luz Solar Psoríase Raios Ultravioleta Vitamina D |
description |
Introduction: Psoriasis is an immunemediated dermatosis characterized by chronic inflammation, abnormal proliferation and aberrant differentiation of keratinocytes, hyperplastic blood vessels and infiltration of inflammatory cells. Psoriasis is a multifactorial disease and is influenced by genetics and epigenetic modifications that can be triggered by environmental factors. Climate and sun exposure may affect psoriasis prevalence and the ultraviolet radiation is a useful treatment. Our objective was to evaluate the relationship between the month of birth and the risk of developing psoriasis.Methods: The monthly distribution of births of patients with psoriasis (n = 755) was compared to that of a control population, comprised by Portuguese individual born during the same period and from the same region (n = 6 560 032).Results: Birth rate of psoriasis patients decreased in October (OR 0.74; 95% CI 0.55 – 0.99; p 0.041). After Bonferroni correction and after grouping the months by trimesters, no statistical significant differences were found.Conclusion: Our results may be related to the particular meteorological characteristics of Portugal that may lead to stabilization of the vitamin D synthesis during the whole year. The perception of the environmental influence on the development of a specific pathology is very important because it allows the establishment of preventive measures that will reduce disease incidence. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-26T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.75.4.872 oai:ojs.revista.spdv.com.pt:article/872 |
url |
https://doi.org/10.29021/spdv.75.4.872 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/872 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/872 https://doi.org/10.29021/spdv.75.4.872 https://revista.spdv.com.pt/index.php/spdv/article/view/872/524 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 4 (2017): Outubro - Dezembro; 337-342 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 4 (2017): Outubro - Dezembro; 337-342 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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