Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://hdl.handle.net/10216/120471 |
Resumo: | Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes. Copyright © 2018 The Authors, some rights reserved. |
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Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animalsAnimalsBacteriaBiochemistryChainsEcosystemsGene transferGenesEndogenous capacitiesEssential nutrientsFunctional characterizationHorizontal gene transferInvertebrate animalsLong chain polyunsaturated fatty acidMarine microbeOmega-3 polyunsaturated fatty acidsPolyunsaturated fatty acidsMarine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes. Copyright © 2018 The Authors, some rights reserved.American Association for the Advancement of Science20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/120471eng2375254810.1126/sciadv.aar6849Kabeya N.Fonseca M.M.Ferrier D.E.K.Navarro J.C.Bay L.K.Francis D.S.Tocher D.R.Castro L.F.C.Monroig O.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:27:48Zoai:repositorio-aberto.up.pt:10216/120471Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:40:59.281088Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
title |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
spellingShingle |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals Kabeya N. Animals Bacteria Biochemistry Chains Ecosystems Gene transfer Genes Endogenous capacities Essential nutrients Functional characterization Horizontal gene transfer Invertebrate animals Long chain polyunsaturated fatty acid Marine microbe Omega-3 polyunsaturated fatty acids Polyunsaturated fatty acids |
title_short |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
title_full |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
title_fullStr |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
title_full_unstemmed |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
title_sort |
Genes for de novo biosynthesis of omega-3 polyunsaturated fatty acids are widespread in animals |
author |
Kabeya N. |
author_facet |
Kabeya N. Fonseca M.M. Ferrier D.E.K. Navarro J.C. Bay L.K. Francis D.S. Tocher D.R. Castro L.F.C. Monroig O. |
author_role |
author |
author2 |
Fonseca M.M. Ferrier D.E.K. Navarro J.C. Bay L.K. Francis D.S. Tocher D.R. Castro L.F.C. Monroig O. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Kabeya N. Fonseca M.M. Ferrier D.E.K. Navarro J.C. Bay L.K. Francis D.S. Tocher D.R. Castro L.F.C. Monroig O. |
dc.subject.por.fl_str_mv |
Animals Bacteria Biochemistry Chains Ecosystems Gene transfer Genes Endogenous capacities Essential nutrients Functional characterization Horizontal gene transfer Invertebrate animals Long chain polyunsaturated fatty acid Marine microbe Omega-3 polyunsaturated fatty acids Polyunsaturated fatty acids |
topic |
Animals Bacteria Biochemistry Chains Ecosystems Gene transfer Genes Endogenous capacities Essential nutrients Functional characterization Horizontal gene transfer Invertebrate animals Long chain polyunsaturated fatty acid Marine microbe Omega-3 polyunsaturated fatty acids Polyunsaturated fatty acids |
description |
Marine ecosystems are responsible for virtually all production of omega-3 (ω3) long-chain polyunsaturated fatty acids (PUFA), which are essential nutrients for vertebrates. Current consensus is that marine microbes account for this production, given their possession of key enzymes including methyl-end (or "ωx") desaturases. ωx desaturases have also been described in a small number of invertebrate animals, but their precise distribution has not been systematically explored. This study identifies 121 ωx desaturase sequences from 80 species within the Cnidaria, Rotifera, Mollusca, Annelida, and Arthropoda. Horizontal gene transfer has contributed to this hitherto unknown widespread distribution. Functional characterization of animal ωx desaturases provides evidence that multiple invertebrates have the ability to produce ω3 PUFA de novo and further biosynthesize ω3 long-chain PUFA. This finding represents a fundamental revision in our understanding of ω3 long-chain PUFA production in global food webs, by revealing that numerous widespread and abundant invertebrates have the endogenous capacity to make significant contributions beyond that coming from marine microbes. Copyright © 2018 The Authors, some rights reserved. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://hdl.handle.net/10216/120471 |
url |
https://hdl.handle.net/10216/120471 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
23752548 10.1126/sciadv.aar6849 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
American Association for the Advancement of Science |
publisher.none.fl_str_mv |
American Association for the Advancement of Science |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799135724290703360 |