Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.22/20555 |
Resumo: | To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prospectively evaluated using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) with 15×9 mm and 3×3 mm angiography protocols. Seven-field photographs of the fundus were obtained for ETDRS staging. Eyes from age-matched healthy subjects were also imaged as control. In eyes of patients with type 2 diabetes without retinopathy or ETDRS levels 20 and 35, retinal capillary closure was in the macular area, with predominant alterations in the parafoveal retinal circulation (inner ring). Retinal capillary closure in ETDRS stages 43-53 becomes predominant in the retinal midperiphery with vessel density average values of 25.2±7.9 (p=0.001) in ETDRS 43 and 23.5±3.4 (p=0.001) in ETDRS 47-53, when evaluating extended areas of 15×9 protocol. Combination of acquisition protocols 3×3 mm and 15×9 mm, using SS-OCTA, allows discrimination between eyes with mild NPDR (ETDRS 10, 20, 35) and eyes with moderate-to-severe NPDR (ETDRS grades 43-53). Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR. |
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Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDRDiagnostic tests/InvestigationImagingRetinaTo test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prospectively evaluated using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) with 15×9 mm and 3×3 mm angiography protocols. Seven-field photographs of the fundus were obtained for ETDRS staging. Eyes from age-matched healthy subjects were also imaged as control. In eyes of patients with type 2 diabetes without retinopathy or ETDRS levels 20 and 35, retinal capillary closure was in the macular area, with predominant alterations in the parafoveal retinal circulation (inner ring). Retinal capillary closure in ETDRS stages 43-53 becomes predominant in the retinal midperiphery with vessel density average values of 25.2±7.9 (p=0.001) in ETDRS 43 and 23.5±3.4 (p=0.001) in ETDRS 47-53, when evaluating extended areas of 15×9 protocol. Combination of acquisition protocols 3×3 mm and 15×9 mm, using SS-OCTA, allows discrimination between eyes with mild NPDR (ETDRS 10, 20, 35) and eyes with moderate-to-severe NPDR (ETDRS grades 43-53). Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR.BMJRepositório Científico do Instituto Politécnico do PortoSantos, TorcatoWarren, Lewis H.Santos, Ana Rita B. M.Marques, Inês PereiraKubach, SophieMendes, Luís G.Sisternes, Luís deMadeira, Maria H.Durbin, MaryCunha-Vaz, José G.2022-05-23T09:50:57Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdftext/plain; charset=utf-8http://hdl.handle.net/10400.22/20555engSantos, T., Warren, L. H., Santos, A. R., Marques, I. P., Kubach, S., Mendes, L. G., Sisternes, L., Madeira, M. H., Durbin, M., & Cunha-Vaz, J. G. (2022). Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR. The British journal of ophthalmology, 106(5), 712–718. https://doi.org/10.1136/bjophthalmol-2020-31789010.1136/bjophthalmol-2020-317890info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:16:03Zoai:recipp.ipp.pt:10400.22/20555Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:40:35.862636Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
title |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
spellingShingle |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR Santos, Torcato Diagnostic tests/Investigation Imaging Retina |
title_short |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
title_full |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
title_fullStr |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
title_full_unstemmed |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
title_sort |
Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR |
author |
Santos, Torcato |
author_facet |
Santos, Torcato Warren, Lewis H. Santos, Ana Rita B. M. Marques, Inês Pereira Kubach, Sophie Mendes, Luís G. Sisternes, Luís de Madeira, Maria H. Durbin, Mary Cunha-Vaz, José G. |
author_role |
author |
author2 |
Warren, Lewis H. Santos, Ana Rita B. M. Marques, Inês Pereira Kubach, Sophie Mendes, Luís G. Sisternes, Luís de Madeira, Maria H. Durbin, Mary Cunha-Vaz, José G. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Politécnico do Porto |
dc.contributor.author.fl_str_mv |
Santos, Torcato Warren, Lewis H. Santos, Ana Rita B. M. Marques, Inês Pereira Kubach, Sophie Mendes, Luís G. Sisternes, Luís de Madeira, Maria H. Durbin, Mary Cunha-Vaz, José G. |
dc.subject.por.fl_str_mv |
Diagnostic tests/Investigation Imaging Retina |
topic |
Diagnostic tests/Investigation Imaging Retina |
description |
To test whether a single or composite set of parameters evaluated with optical coherence tomography angiography (OCTA), representing retinal capillary closure, can predict non-proliferative diabetic retinopathy (NPDR) staging according to the gold standard ETDRS grading scheme. 105 patients with diabetes, either without retinopathy or with different degrees of retinopathy (NPDR up to ETDRS grade 53), were prospectively evaluated using swept-source OCTA (SS-OCTA, PlexElite, Carl Zeiss Meditec) with 15×9 mm and 3×3 mm angiography protocols. Seven-field photographs of the fundus were obtained for ETDRS staging. Eyes from age-matched healthy subjects were also imaged as control. In eyes of patients with type 2 diabetes without retinopathy or ETDRS levels 20 and 35, retinal capillary closure was in the macular area, with predominant alterations in the parafoveal retinal circulation (inner ring). Retinal capillary closure in ETDRS stages 43-53 becomes predominant in the retinal midperiphery with vessel density average values of 25.2±7.9 (p=0.001) in ETDRS 43 and 23.5±3.4 (p=0.001) in ETDRS 47-53, when evaluating extended areas of 15×9 protocol. Combination of acquisition protocols 3×3 mm and 15×9 mm, using SS-OCTA, allows discrimination between eyes with mild NPDR (ETDRS 10, 20, 35) and eyes with moderate-to-severe NPDR (ETDRS grades 43-53). Retinal capillary closure, quantified by SS-OCTA, can identify NPDR severity progression. It is located mainly in the perifoveal retinal capillary circulation in the initial stages of NPDR, whereas the retinal midperiphery is predominantly affected in moderate-to-severe NPDR. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-23T09:50:57Z 2022 2022-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.22/20555 |
url |
http://hdl.handle.net/10400.22/20555 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Santos, T., Warren, L. H., Santos, A. R., Marques, I. P., Kubach, S., Mendes, L. G., Sisternes, L., Madeira, M. H., Durbin, M., & Cunha-Vaz, J. G. (2022). Swept-source OCTA quantification of capillary closure predicts ETDRS severity staging of NPDR. The British journal of ophthalmology, 106(5), 712–718. https://doi.org/10.1136/bjophthalmol-2020-317890 10.1136/bjophthalmol-2020-317890 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf text/plain; charset=utf-8 |
dc.publisher.none.fl_str_mv |
BMJ |
publisher.none.fl_str_mv |
BMJ |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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