The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder

Detalhes bibliográficos
Autor(a) principal: Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
Data de Publicação: 2023
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163460
Resumo: Funding Information: This work was supported by the National Institutes of Health (Grant Nos. R21 DC018098 , R33 DA047527 , and F32 MH122058 ), Canadian Institute for Health Research Canadian Research Chairs stipend (Grant No. 1024586), National Institute of Mental Health (Grant No. R01MH120219 [to MGN]), The Netherlands Organisation for Health Research and Development (Zon MW) (Grant Nos. 849200011 and 531003014 [to MGN]), Dutch Research Council (NOW) Veni Grant (Grant No. VI.Veni.191G.030 [to MGN]), and Jacobs Foundation Fellowship Program (to MGN). Financial support for the PGC PTSD was provided by Cohen Veterans Bioscience, Stanley Center for Psychiatric Research at the Broad Institute, One Mind, and National Institute of Mental Health (Grant Nos. R01MH106595 , R01MH124847 , and R01MH124851 ). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2022 Society of Biological Psychiatry
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spelling The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress DisorderA Two-Sample Mendelian Randomization and Population-Based Sibling Comparison StudyADHDCausal inferenceComorbiditiesEpidemiologyGenome-wide association studyPTSDBiological PsychiatryFunding Information: This work was supported by the National Institutes of Health (Grant Nos. R21 DC018098 , R33 DA047527 , and F32 MH122058 ), Canadian Institute for Health Research Canadian Research Chairs stipend (Grant No. 1024586), National Institute of Mental Health (Grant No. R01MH120219 [to MGN]), The Netherlands Organisation for Health Research and Development (Zon MW) (Grant Nos. 849200011 and 531003014 [to MGN]), Dutch Research Council (NOW) Veni Grant (Grant No. VI.Veni.191G.030 [to MGN]), and Jacobs Foundation Fellowship Program (to MGN). Financial support for the PGC PTSD was provided by Cohen Veterans Bioscience, Stanley Center for Psychiatric Research at the Broad Institute, One Mind, and National Institute of Mental Health (Grant Nos. R01MH106595 , R01MH124847 , and R01MH124851 ). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2022 Society of Biological PsychiatryBackground: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated, but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling comparisons to clarify the direction of this relationship. Methods: Linkage disequilibrium score regression and 2-sample Mendelian randomization were used to test for genetic correlation (rg) and bidirectional causal effects using European ancestry genome-wide association studies of ADHD (20,183 cases and 35,191 controls) and 6 PTSD definitions (up to 320,369 individuals). Several additional variables were included in the analysis to verify the independence of the ADHD-PTSD relationship. In a population-based sibling comparison (N = 2,082,118 individuals), Cox regression models were fitted to account for time at risk, a range of sociodemographic factors, and unmeasured familial confounders (via sibling comparisons). Results: ADHD and PTSD had consistent rg (rg range, 0.43–0.52; p < .001). ADHD genetic liability was causally linked with increased risk for PTSD (β = 0.367; 95% CI, 0.186–0.552; p = 7.68 × 10−5). This result was not affected by heterogeneity, horizontal pleiotropy (Mendelian randomization Egger intercept = 4.34 × 10−4, p = .961), or other phenotypes and was consistent across PTSD datasets. However, we found no consistent associations between PTSD genetic liability and ADHD risk. Individuals diagnosed with ADHD were at a higher risk for developing PTSD than their undiagnosed sibling (hazard ratio = 2.37; 95% CI, 1.98–3.53). Conclusions: Our findings add novel evidence supporting the need for early and effective treatment of ADHD, as patients with this diagnosis are at significantly higher risk to develop PTSD later in life.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNPost-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium2024-02-12T23:48:24Z2023-02-152023-02-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/163460eng0006-3223PURE: 83131227https://doi.org/10.1016/j.biopsych.2022.08.012info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:46:51Zoai:run.unl.pt:10362/163460Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:59:24.991976Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study
title The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
spellingShingle The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
ADHD
Causal inference
Comorbidities
Epidemiology
Genome-wide association study
PTSD
Biological Psychiatry
title_short The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
title_full The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
title_fullStr The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
title_full_unstemmed The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
title_sort The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder
author Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
author_facet Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
author_role author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Post-Traumatic Stress Disorder Working Group of the Psychiatric Genomics Consortium
dc.subject.por.fl_str_mv ADHD
Causal inference
Comorbidities
Epidemiology
Genome-wide association study
PTSD
Biological Psychiatry
topic ADHD
Causal inference
Comorbidities
Epidemiology
Genome-wide association study
PTSD
Biological Psychiatry
description Funding Information: This work was supported by the National Institutes of Health (Grant Nos. R21 DC018098 , R33 DA047527 , and F32 MH122058 ), Canadian Institute for Health Research Canadian Research Chairs stipend (Grant No. 1024586), National Institute of Mental Health (Grant No. R01MH120219 [to MGN]), The Netherlands Organisation for Health Research and Development (Zon MW) (Grant Nos. 849200011 and 531003014 [to MGN]), Dutch Research Council (NOW) Veni Grant (Grant No. VI.Veni.191G.030 [to MGN]), and Jacobs Foundation Fellowship Program (to MGN). Financial support for the PGC PTSD was provided by Cohen Veterans Bioscience, Stanley Center for Psychiatric Research at the Broad Institute, One Mind, and National Institute of Mental Health (Grant Nos. R01MH106595 , R01MH124847 , and R01MH124851 ). The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2022 Society of Biological Psychiatry
publishDate 2023
dc.date.none.fl_str_mv 2023-02-15
2023-02-15T00:00:00Z
2024-02-12T23:48:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163460
url http://hdl.handle.net/10362/163460
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0006-3223
PURE: 83131227
https://doi.org/10.1016/j.biopsych.2022.08.012
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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