Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/145858 |
Resumo: | Copyright © 2022 Medeiros, Ingham, Nanque, Correia, Stegger, Andersen, Fisker, Benn, Lanaspa, Silveira and Abrantes. |
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Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infantsMicrobiologyInfectious DiseasesSDG 3 - Good Health and Well-beingCopyright © 2022 Medeiros, Ingham, Nanque, Correia, Stegger, Andersen, Fisker, Benn, Lanaspa, Silveira and Abrantes.After the eradication of polio infection, the plan is to phase-out the live-attenuated oral polio vaccine (OPV). Considering the protective non-specific effects (NSE) of OPV on unrelated pathogens, the withdrawal may impact child health negatively. Within a cluster-randomized trial, we carried out 16S rRNA deep sequencing analysis of fecal and nasopharyngeal microbial content of Bissau-Guinean infants aged 4-8 months, before and after 2 months of OPV revaccination (revaccinated infants = 47) vs. no OPV revaccination (control infants = 47). The aim was to address changes in the gut and upper respiratory bacterial microbiotas due to revaccination. Alpha-diversity for both microbiotas increased similarly over time in OPV-revaccinated infants and controls, whereas greater changes over time in the bacterial composition of gut ( p adjusted < 0.001) and upper respiratory microbiotas ( p adjusted = 0.018) were observed in the former. Taxonomic analysis of gut bacterial microbiota revealed a decrease over time in the median proportion of Bifidobacterium longum for all infants (25-14.3%, p = 0.0006 in OPV-revaccinated infants and 25.3-11.6%, p = 0.01 in controls), compatible with the reported weaning. Also, it showed a restricted increase in the median proportion of Prevotella_9 genus in controls (1.4-7.1%, p = 0.02), whereas in OPV revaccinated infants an increase over time in Prevotellaceae family (7.2-17.4%, p = 0.005) together with a reduction in median proportion of potentially pathogenic/opportunistic genera such as Escherichia/ Shigella (5.8-3.4%, p = 0.01) were observed. Taxonomic analysis of upper respiratory bacterial microbiota revealed an increase over time in median proportions of potentially pathogenic/opportunistic genera in controls, such as Streptococcus (2.9-11.8%, p = 0.001 and Hemophilus (11.3-20.5%, p = 0.03), not observed in OPV revaccinated infants. In conclusion, OPV revaccination was associated with a healthier microbiome composition 2 months after revaccination, based on a more abundant and diversified bacterial community of Prevotellaceae and fewer pathogenic/opportunistic organisms. Further information on species-level differentiation and functional analysis of microbiome content are warranted to elucidate the impact of OPV-associated changes in bacterial microbiota on child health.Vector borne diseases and pathogens (VBD)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)TB, HIV and opportunistic diseases and pathogens (THOP)RUNMedeiros, Márcia MeloIngham, Anna CäciliaNanque, Line MøllerCorreia, ClaudinoStegger, MarcAndersen, Paal SkytFisker, Ane BaerentBenn, Christine StabellLanaspa, MiguelSilveira, HenriqueAbrantes, Patrícia2022-11-28T22:15:49Z20222022-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/145858eng1664-302XPURE: 47894535https://doi.org/10.3389/fmicb.2022.1016220info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:33Zoai:run.unl.pt:10362/145858Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:18.301787Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| title |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| spellingShingle |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants Medeiros, Márcia Melo Microbiology Infectious Diseases SDG 3 - Good Health and Well-being |
| title_short |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| title_full |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| title_fullStr |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| title_full_unstemmed |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| title_sort |
Oral polio revaccination is associated with changes in gut and upper respiratory microbiomes of infants |
| author |
Medeiros, Márcia Melo |
| author_facet |
Medeiros, Márcia Melo Ingham, Anna Cäcilia Nanque, Line Møller Correia, Claudino Stegger, Marc Andersen, Paal Skyt Fisker, Ane Baerent Benn, Christine Stabell Lanaspa, Miguel Silveira, Henrique Abrantes, Patrícia |
| author_role |
author |
| author2 |
Ingham, Anna Cäcilia Nanque, Line Møller Correia, Claudino Stegger, Marc Andersen, Paal Skyt Fisker, Ane Baerent Benn, Christine Stabell Lanaspa, Miguel Silveira, Henrique Abrantes, Patrícia |
| author2_role |
author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Vector borne diseases and pathogens (VBD) Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) TB, HIV and opportunistic diseases and pathogens (THOP) RUN |
| dc.contributor.author.fl_str_mv |
Medeiros, Márcia Melo Ingham, Anna Cäcilia Nanque, Line Møller Correia, Claudino Stegger, Marc Andersen, Paal Skyt Fisker, Ane Baerent Benn, Christine Stabell Lanaspa, Miguel Silveira, Henrique Abrantes, Patrícia |
| dc.subject.por.fl_str_mv |
Microbiology Infectious Diseases SDG 3 - Good Health and Well-being |
| topic |
Microbiology Infectious Diseases SDG 3 - Good Health and Well-being |
| description |
Copyright © 2022 Medeiros, Ingham, Nanque, Correia, Stegger, Andersen, Fisker, Benn, Lanaspa, Silveira and Abrantes. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-28T22:15:49Z 2022 2022-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/145858 |
| url |
http://hdl.handle.net/10362/145858 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1664-302X PURE: 47894535 https://doi.org/10.3389/fmicb.2022.1016220 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
| instacron_str |
RCAAP |
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RCAAP |
| reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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