Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?

Detalhes bibliográficos
Autor(a) principal: Mendes-Bastos, P.
Data de Publicação: 2017
Outros Autores: Macedo, R., Duarte, R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/5468
Resumo: Research letter
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spelling Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?Hidradenitis SuppurativaTuberculosisInfecções RespiratóriasResearch letterHidradenitis suppurativa (HS) is a chronic, recurrent and debilitating skin disease of the hair follicle that is accompanied by systemic inflammation. Treating HS is challenging, and therapeutic tools as diverse as topical and systemic antibiotics, biologics, intralesional steroids, surgical procedures or light and laser therapies are frequently needed. The combination of oral clindamycin and rifampicin has been suggested as a possible treatment regimen. Five studies have evaluated the efficacy of this combination, the majority of which reported the use of clindamycin 600 mg daily + rifampicin 600 mg daily with an average length of 10 consecutive weeks.1–5 In three out of four studies, 10-week follow-up yielded complete remission in 32% (32/116) of patients1–3; in another study, a 1-year follow-up demonstrated sustained efficacy in only seven of 26 patients.5 Scheinfeld has discussed why rifampicin is a key drug in the treatment of HS, pointing out its antibacterial and anti-inflammatory effects, its activity on bacterial biofilms, its effect against granulomas and its immunomodulatory properties on neutrophils. (...)Wiley/British Association of DermatologistsRepositório Científico do Instituto Nacional de SaúdeMendes-Bastos, P.Macedo, R.Duarte, R.2018-03-23T10:52:53Z2017-102017-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/5468engBr J Dermatol. 2017 Oct;177(4):e150-e151. doi: 10.1111/bjd.15500. Epub 2017 Sep 27.0007-096310.1111/bjd.15500info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:53Zoai:repositorio.insa.pt:10400.18/5468Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:40:09.557219Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
title Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
spellingShingle Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
Mendes-Bastos, P.
Hidradenitis Suppurativa
Tuberculosis
Infecções Respiratórias
title_short Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
title_full Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
title_fullStr Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
title_full_unstemmed Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
title_sort Treatment of hidradenitis suppurativa with rifampicin: have we forgotten tuberculosis?
author Mendes-Bastos, P.
author_facet Mendes-Bastos, P.
Macedo, R.
Duarte, R.
author_role author
author2 Macedo, R.
Duarte, R.
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Mendes-Bastos, P.
Macedo, R.
Duarte, R.
dc.subject.por.fl_str_mv Hidradenitis Suppurativa
Tuberculosis
Infecções Respiratórias
topic Hidradenitis Suppurativa
Tuberculosis
Infecções Respiratórias
description Research letter
publishDate 2017
dc.date.none.fl_str_mv 2017-10
2017-10-01T00:00:00Z
2018-03-23T10:52:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/5468
url http://hdl.handle.net/10400.18/5468
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Br J Dermatol. 2017 Oct;177(4):e150-e151. doi: 10.1111/bjd.15500. Epub 2017 Sep 27.
0007-0963
10.1111/bjd.15500
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
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dc.publisher.none.fl_str_mv Wiley/British Association of Dermatologists
publisher.none.fl_str_mv Wiley/British Association of Dermatologists
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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