Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3857 |
Resumo: | Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal. Hypercholesterolemia has a causal role in atherosclerotic CVD. Guidelines recommend that cardiovascular (CV) risk reduction should be individualized and treatment goals identified. Low-density lipoprotein cholesterol (LDL-C) is the primary treatment target. Methods: DISGEN-LIPID was a cross-sectional observational study conducted in 24 centers in Portugal in dyslipidemic patients aged ≥40 years, on lipid-lowering therapy (LLT) for at least three months and with an available lipid profile in the previous six months. Results: A total of 368 patients were analyzed: 48.9% men and 51.1% women (93.9% postmenopausal), of whom 73% had a SCORE of high or very high CV risk. One quarter had a family history of premature CVD; 31% had diabetes; 26% coronary heart disease; 9.5% cerebrovascular disease; and 4.1% peripheral arterial disease. Mean baseline lipid values were total cholesterol (TC) 189 mg/dl, LDL-C 116 mg/dl, high-density lipoprotein cholesterol (HDL-C) 53.5 mg/dl, and triglycerides (TG) 135 mg/dl. Women had higher TC (p<0.001), LDL-C (non-significant) and HDL-C (p<0.001), and lower TG (p=0.002); 57% of men and 63% of women had LDL-C>100 mg/dl (p=0.28), and 58% of men and 47% of women had LDL-C>70 mg/dl (p=0.933). Conclusion: These observational data show that, despite their high-risk profile, more than half of patients under LLT, both men and women, did not achieve the recommended target levels for LDL-C, and a large proportion also had abnormal HDL-C and/or TG. This is a renewed opportunity to improve clinical practice in CV prevention. |
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Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID StudyAlterações Persistentes do Perfil Lipídico na Prática Clínica nos Doentes Adultos Portugueses com Dislipidemia em Tratamento com Antidislipidémicos. Dados do Estudo DISGEN-LIPIDHSM MEDAdultAgedFemaleMaleBiomarkers / bloodCardiovascular Diseases / epidemiologyCardiovascular Diseases / etiologyCardiovascular Diseases / prevention & controlCross-Sectional StudiesDyslipidemias / bloodDyslipidemias / complicationsDyslipidemias / drug therapyHumansHypolipidemic Agents / therapeutic useLipids / bloodMiddle AgedMorbidity / trendsPortugal / epidemiologyRegistriesRetrospective StudiesSurvival Rate / trendsIntroduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal. Hypercholesterolemia has a causal role in atherosclerotic CVD. Guidelines recommend that cardiovascular (CV) risk reduction should be individualized and treatment goals identified. Low-density lipoprotein cholesterol (LDL-C) is the primary treatment target. Methods: DISGEN-LIPID was a cross-sectional observational study conducted in 24 centers in Portugal in dyslipidemic patients aged ≥40 years, on lipid-lowering therapy (LLT) for at least three months and with an available lipid profile in the previous six months. Results: A total of 368 patients were analyzed: 48.9% men and 51.1% women (93.9% postmenopausal), of whom 73% had a SCORE of high or very high CV risk. One quarter had a family history of premature CVD; 31% had diabetes; 26% coronary heart disease; 9.5% cerebrovascular disease; and 4.1% peripheral arterial disease. Mean baseline lipid values were total cholesterol (TC) 189 mg/dl, LDL-C 116 mg/dl, high-density lipoprotein cholesterol (HDL-C) 53.5 mg/dl, and triglycerides (TG) 135 mg/dl. Women had higher TC (p<0.001), LDL-C (non-significant) and HDL-C (p<0.001), and lower TG (p=0.002); 57% of men and 63% of women had LDL-C>100 mg/dl (p=0.28), and 58% of men and 47% of women had LDL-C>70 mg/dl (p=0.933). Conclusion: These observational data show that, despite their high-risk profile, more than half of patients under LLT, both men and women, did not achieve the recommended target levels for LDL-C, and a large proportion also had abnormal HDL-C and/or TG. This is a renewed opportunity to improve clinical practice in CV prevention.Elsevier EspañaRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEMarques da Silva, PAguiar, CMorais, JDISGEN-LIPID study Investigators2021-09-28T15:17:53Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3857engRev Port Cardiol (Engl Ed). 2019 Aug;38(8):559-569.10.1016/j.repc.2019.02.009. Einfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:44:28ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study Alterações Persistentes do Perfil Lipídico na Prática Clínica nos Doentes Adultos Portugueses com Dislipidemia em Tratamento com Antidislipidémicos. Dados do Estudo DISGEN-LIPID |
title |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study |
spellingShingle |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study Marques da Silva, P HSM MED Adult Aged Female Male Biomarkers / blood Cardiovascular Diseases / epidemiology Cardiovascular Diseases / etiology Cardiovascular Diseases / prevention & control Cross-Sectional Studies Dyslipidemias / blood Dyslipidemias / complications Dyslipidemias / drug therapy Humans Hypolipidemic Agents / therapeutic use Lipids / blood Middle Aged Morbidity / trends Portugal / epidemiology Registries Retrospective Studies Survival Rate / trends |
title_short |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study |
title_full |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study |
title_fullStr |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study |
title_full_unstemmed |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study |
title_sort |
Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study |
author |
Marques da Silva, P |
author_facet |
Marques da Silva, P Aguiar, C Morais, J DISGEN-LIPID study Investigators |
author_role |
author |
author2 |
Aguiar, C Morais, J DISGEN-LIPID study Investigators |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Marques da Silva, P Aguiar, C Morais, J DISGEN-LIPID study Investigators |
dc.subject.por.fl_str_mv |
HSM MED Adult Aged Female Male Biomarkers / blood Cardiovascular Diseases / epidemiology Cardiovascular Diseases / etiology Cardiovascular Diseases / prevention & control Cross-Sectional Studies Dyslipidemias / blood Dyslipidemias / complications Dyslipidemias / drug therapy Humans Hypolipidemic Agents / therapeutic use Lipids / blood Middle Aged Morbidity / trends Portugal / epidemiology Registries Retrospective Studies Survival Rate / trends |
topic |
HSM MED Adult Aged Female Male Biomarkers / blood Cardiovascular Diseases / epidemiology Cardiovascular Diseases / etiology Cardiovascular Diseases / prevention & control Cross-Sectional Studies Dyslipidemias / blood Dyslipidemias / complications Dyslipidemias / drug therapy Humans Hypolipidemic Agents / therapeutic use Lipids / blood Middle Aged Morbidity / trends Portugal / epidemiology Registries Retrospective Studies Survival Rate / trends |
description |
Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal. Hypercholesterolemia has a causal role in atherosclerotic CVD. Guidelines recommend that cardiovascular (CV) risk reduction should be individualized and treatment goals identified. Low-density lipoprotein cholesterol (LDL-C) is the primary treatment target. Methods: DISGEN-LIPID was a cross-sectional observational study conducted in 24 centers in Portugal in dyslipidemic patients aged ≥40 years, on lipid-lowering therapy (LLT) for at least three months and with an available lipid profile in the previous six months. Results: A total of 368 patients were analyzed: 48.9% men and 51.1% women (93.9% postmenopausal), of whom 73% had a SCORE of high or very high CV risk. One quarter had a family history of premature CVD; 31% had diabetes; 26% coronary heart disease; 9.5% cerebrovascular disease; and 4.1% peripheral arterial disease. Mean baseline lipid values were total cholesterol (TC) 189 mg/dl, LDL-C 116 mg/dl, high-density lipoprotein cholesterol (HDL-C) 53.5 mg/dl, and triglycerides (TG) 135 mg/dl. Women had higher TC (p<0.001), LDL-C (non-significant) and HDL-C (p<0.001), and lower TG (p=0.002); 57% of men and 63% of women had LDL-C>100 mg/dl (p=0.28), and 58% of men and 47% of women had LDL-C>70 mg/dl (p=0.933). Conclusion: These observational data show that, despite their high-risk profile, more than half of patients under LLT, both men and women, did not achieve the recommended target levels for LDL-C, and a large proportion also had abnormal HDL-C and/or TG. This is a renewed opportunity to improve clinical practice in CV prevention. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2021-09-28T15:17:53Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3857 |
url |
http://hdl.handle.net/10400.17/3857 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Rev Port Cardiol (Engl Ed). 2019 Aug;38(8):559-569. 10.1016/j.repc.2019.02.009. E |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier España |
publisher.none.fl_str_mv |
Elsevier España |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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