Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development

Detalhes bibliográficos
Autor(a) principal: Fernandes, Mónica T.
Data de Publicação: 2016
Outros Autores: Dejardin, Emmanuel, Rodrigues Dos Santos, Nuno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/9527
Resumo: The LT alpha(1)beta(2) and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LT beta R). Interestingly, since the discovery of these proteins, accumulating evidence has pinpointed a role for LT beta R signaling in carcinogenesis. Early studies have shown a potential anti-tumoral role in a subset of solid cancers either by triggering apoptosis in malignant cells or by eliciting an anti-tumor immune response. However, more recent studies provided robust evidence that LT beta R signaling is also involved in diverse cell-intrinsic and microenvironment-dependent pro-oncogenic mechanisms, affecting several solid and hematological malignancies. Consequently, the usefulness of LT beta R signaling axis blockade has been investigated as a potential therapeutic approach for cancer. Considering the seemingly opposite roles of LT beta R signaling in diverse cancer types and their key implications for therapy, we here extensively review the different mechanisms by which LT beta R activation affects carcinogenesis, focusing on the diverse contexts and different models assessed. (C) 2016 Elsevier B.V. All rights reserved.
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spelling Context-dependent roles for lymphotoxin-beta receptor signaling in cancer developmentThe LT alpha(1)beta(2) and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LT beta R). Interestingly, since the discovery of these proteins, accumulating evidence has pinpointed a role for LT beta R signaling in carcinogenesis. Early studies have shown a potential anti-tumoral role in a subset of solid cancers either by triggering apoptosis in malignant cells or by eliciting an anti-tumor immune response. However, more recent studies provided robust evidence that LT beta R signaling is also involved in diverse cell-intrinsic and microenvironment-dependent pro-oncogenic mechanisms, affecting several solid and hematological malignancies. Consequently, the usefulness of LT beta R signaling axis blockade has been investigated as a potential therapeutic approach for cancer. Considering the seemingly opposite roles of LT beta R signaling in diverse cancer types and their key implications for therapy, we here extensively review the different mechanisms by which LT beta R activation affects carcinogenesis, focusing on the diverse contexts and different models assessed. (C) 2016 Elsevier B.V. All rights reserved.SapientiaFernandes, Mónica T.Dejardin, EmmanuelRodrigues Dos Santos, Nuno2017-04-07T15:56:48Z2016-042016-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/9527eng0304-419XAUT: NRS02238;10.1016/j.bbcan.2016.02.005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:21:00Zoai:sapientia.ualg.pt:10400.1/9527Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:01:27.077583Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
title Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
spellingShingle Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
Fernandes, Mónica T.
title_short Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
title_full Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
title_fullStr Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
title_full_unstemmed Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
title_sort Context-dependent roles for lymphotoxin-beta receptor signaling in cancer development
author Fernandes, Mónica T.
author_facet Fernandes, Mónica T.
Dejardin, Emmanuel
Rodrigues Dos Santos, Nuno
author_role author
author2 Dejardin, Emmanuel
Rodrigues Dos Santos, Nuno
author2_role author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Fernandes, Mónica T.
Dejardin, Emmanuel
Rodrigues Dos Santos, Nuno
description The LT alpha(1)beta(2) and LIGHT TNF superfamily cytokines exert pleiotropic physiological functions through the activation of their cognate lymphotoxin-beta receptor (LT beta R). Interestingly, since the discovery of these proteins, accumulating evidence has pinpointed a role for LT beta R signaling in carcinogenesis. Early studies have shown a potential anti-tumoral role in a subset of solid cancers either by triggering apoptosis in malignant cells or by eliciting an anti-tumor immune response. However, more recent studies provided robust evidence that LT beta R signaling is also involved in diverse cell-intrinsic and microenvironment-dependent pro-oncogenic mechanisms, affecting several solid and hematological malignancies. Consequently, the usefulness of LT beta R signaling axis blockade has been investigated as a potential therapeutic approach for cancer. Considering the seemingly opposite roles of LT beta R signaling in diverse cancer types and their key implications for therapy, we here extensively review the different mechanisms by which LT beta R activation affects carcinogenesis, focusing on the diverse contexts and different models assessed. (C) 2016 Elsevier B.V. All rights reserved.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
2016-04-01T00:00:00Z
2017-04-07T15:56:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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AUT: NRS02238;
10.1016/j.bbcan.2016.02.005
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