Biomarkers for tuberculosis: the case for lipoarabinomannan
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/62407 |
Resumo: | Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests. There is a high potential for urinary LAM-based POC tests for the diagnosis of active TB. Some technical challenges to optimised sensitivity of the test will be detailed. A method to quantify LAM in urine or serum should be further explored as a test of treatment effect. Recent data on the immune response to LAM suggest that markers for host response to LAM should be investigated for a prognostic test to recognise individuals at the greatest risk of disease activation. |
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Biomarkers for tuberculosis: the case for lipoarabinomannanCiências Médicas::Medicina BásicaScience & TechnologyTuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests. There is a high potential for urinary LAM-based POC tests for the diagnosis of active TB. Some technical challenges to optimised sensitivity of the test will be detailed. A method to quantify LAM in urine or serum should be further explored as a test of treatment effect. Recent data on the immune response to LAM suggest that markers for host response to LAM should be investigated for a prognostic test to recognise individuals at the greatest risk of disease activation.European Respiratory SocietyUniversidade do MinhoCorreia-Neves, MFröberg, GabrielleKorshun, LiudmylaViegas, SofiaVaz, PaulaRamanlal, NehabenBruchfeld, JudithHamasur, BestonBrennan, PatrickKällenius, Gunilla2019-022019-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/62407engCorreia-Neves, M., Fröberg, G., Korshun, L., et. al. (2019). Biomarkers for tuberculosis: the case for lipoarabinomannan. ERJ open research, 5(1), 00115-2018.2312-054110.1183/23120541.00115-2018https://openres.ersjournals.com/content/5/1/00115-2018.abstractinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:13:22Zoai:repositorium.sdum.uminho.pt:1822/62407Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:05:25.878737Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
title |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
spellingShingle |
Biomarkers for tuberculosis: the case for lipoarabinomannan Correia-Neves, M Ciências Médicas::Medicina Básica Science & Technology |
title_short |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
title_full |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
title_fullStr |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
title_full_unstemmed |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
title_sort |
Biomarkers for tuberculosis: the case for lipoarabinomannan |
author |
Correia-Neves, M |
author_facet |
Correia-Neves, M Fröberg, Gabrielle Korshun, Liudmyla Viegas, Sofia Vaz, Paula Ramanlal, Nehaben Bruchfeld, Judith Hamasur, Beston Brennan, Patrick Källenius, Gunilla |
author_role |
author |
author2 |
Fröberg, Gabrielle Korshun, Liudmyla Viegas, Sofia Vaz, Paula Ramanlal, Nehaben Bruchfeld, Judith Hamasur, Beston Brennan, Patrick Källenius, Gunilla |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Correia-Neves, M Fröberg, Gabrielle Korshun, Liudmyla Viegas, Sofia Vaz, Paula Ramanlal, Nehaben Bruchfeld, Judith Hamasur, Beston Brennan, Patrick Källenius, Gunilla |
dc.subject.por.fl_str_mv |
Ciências Médicas::Medicina Básica Science & Technology |
topic |
Ciências Médicas::Medicina Básica Science & Technology |
description |
Tuberculosis (TB) is considered the most onerous of infectious diseases according to recent reports from the World Health Organization. Available tests for TB diagnosis present severe limitations, and a reliable point-of-care (POC) diagnostic test does not exist. Neither is there a test to discern between the different stages of TB, and in particular to predict which patients with Mycobacterium tuberculosis infection and no clinical signs are more at risk of advancing to overt disease. We here review the usefulness of mycobacterial lipoarabinomannan (LAM) as a diagnostic marker for active and latent TB and, also, aspects of the immune response to LAM relevant to such tests. There is a high potential for urinary LAM-based POC tests for the diagnosis of active TB. Some technical challenges to optimised sensitivity of the test will be detailed. A method to quantify LAM in urine or serum should be further explored as a test of treatment effect. Recent data on the immune response to LAM suggest that markers for host response to LAM should be investigated for a prognostic test to recognise individuals at the greatest risk of disease activation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02 2019-02-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/62407 |
url |
http://hdl.handle.net/1822/62407 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Correia-Neves, M., Fröberg, G., Korshun, L., et. al. (2019). Biomarkers for tuberculosis: the case for lipoarabinomannan. ERJ open research, 5(1), 00115-2018. 2312-0541 10.1183/23120541.00115-2018 https://openres.ersjournals.com/content/5/1/00115-2018.abstract |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
European Respiratory Society |
publisher.none.fl_str_mv |
European Respiratory Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132466397577216 |